Protein Alignment MRTFB and BCK1

DIOPT Version :10

• Sequence 1: NP_001295071.1
• Gene: MRTFB / 57496
• HGNCID: 29819
• Length: 1099
• Species: Homo sapiens
• Sequence 2: NP_012440.1
• Gene: BCK1 / 853350
• SGDID: S000003631
• Length: 1478
• Species: Saccharomyces cerevisiae
• Alignment Length: 1084
• Identity: 205/1084 - (18%)
• Similarity: 374/1084 - (34%)
• Gaps: 296/1084 - (27%)

Human   180 HTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSP--TVPEF 242
            ||.   |..:.:|......||.|  |..|..|.|:...:.|...:..:..:||.:::|  |..:|
Yeast    12 HTH---SRSDSNSSVKFGHQPTS--SVASTKSSSKSPRATSRKSIYDDIRSQFPNLTPNSTSSQF 71

Human   243 LKTPPTADQ-----PPPRPAAPVL--PTN-TVSSAK--PGPALVKQSH----------------- 280
            .::.|..:|     .....:|..|  ||: |.||.|  .||:.:..|.
Yeast    72 YESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLI 136

Human   281 ----PKNPND--KHRSK---KCKD-PKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQL 335
                |.:|::  .||..   |..| |:..:...|.||..     |.:        :.:||.....
Yeast   137 LSWDPTDPDEWTMHRVTSWFKFHDFPESWILFFKKHQLF-----GHR--------FIKLLAYDNF 188

Human   336 FLQLQILSQQK--QHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPS 398
            .:..:.|.|.|  .:..:|.:|    |....||..:.:....:|:.....:::|..::.......
Yeast   189 AVYEKYLPQTKTASYTRFQQLL----KKTMTKNVTNSHIRQKSASKLKSSRSSSESIKSKLKNSK 249

Human   399 SLDDLKVSELKTELKLRGLPVSGTKPD---LIERLKPYQEVNS-SGLAAGGIVAV----SSSAIV 455
            |.:|:..|...:|..|.......:|.|   .:.....:|:..| |.|.....:::    ||:|..
Yeast   250 SQEDISNSRSTSESALSPTKSGPSKTDEKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASS 314

Human   456 TSNP-EVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSL--ST 517
            ..:| .:.:::|... |:.:.|:.:..|:..||...|..:.....|.      |.|.:|||  |.
Yeast   315 AKSPSNIKLSIPARP-HSIIESNSTLTKSASPPASPSYPSIFRRHHK------SSSSESSLLNSL 372

Human   518 DDTNMADTFTEIMTMMSP-SQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQI 581
            ..:.:.:   |..|..:| ...|||..|....::...:..||.|....|..::....|..|.|:
Yeast   373 FGSGIGE---EAPTKPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKFKR- 433

Human   582 EELKRKLEQEQKLVEVLKMQLEVEKRG------QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKD 640
                             |.|:.|....      .|:.|          |:||:....:|.....|
Yeast   434 -----------------KSQIGVPSPNTVAYVTSQETP----------SLKSNSSTATLTVQTAD 471

Human   641 EASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQ----------EVPVGQAEQQSVV 695
             .::|..|||..|||..::...:.:||.....::......|:          .|||....|:..|
Yeast   472 -VNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTASFKETYPDCINPDKTVPVPVNNQKYSV 535

Human   696 SQFYVSSQGQPPPAV---VAQPQALLTTQTAQLLLPVSIQGSS---------------------- 735
            ..|.:..:..|....   .::.:.:|.|:.....:|::::..:
Yeast   536 KNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSFVPLNLKSVAKLSSFKESALTKLGINHKNVTF 600

Human   736 -VTSVQLPVG-------------SLKLQTS------PQAGMQTQPQ---IATAAQIP------TA 771
             :|.....:|             ||.|.||      .|..:|.:|:   :.:...:|      .:
Yeast   601 HMTDFDCDIGAAIPDDTLEFLKKSLFLNTSGKIYIKDQMKLQQKPKPAPLTSENNVPLKSVKSKS 665

Human   772 ALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPA------PAVQQPFINK 830
            ::.||.:..:..|.|.             .:.|   ||:.:..:..|.:      |.....:.::
Yeast   666 SMRSGTSSLIASTDDV-------------SIVT---SSSDITSFDEHASGSGRRYPQTPSYYYDR 714

Human   831 ASNS--------------VLQSRNAPLPSLQNGP----NTPNKPSSPPPPQQFVVQHSLFGSPVA 877
            .||:              :....|||....:..|    |.|:|.|....|           :|:.
Yeast   715 VSNTNPTEELNYWNIKEVLSHEENAPKMVFKTSPKLELNLPDKGSKLNIP-----------TPIT 768

Human   878 KTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSP---ISKMRP 939
            :.:....: :.:::...|     ||...|.::..      ....|:: |.:|.|.|   .|..|.
Yeast   769 ENESKSSF-QVLRKDEGT-----EIDFNHRRESP------YTKPELA-PKREAPKPPANTSPQRT 820

Human   940 VTASITTMPV-----NTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPL 999
            ::.|....|:     :|.:||......:.|.:...|:.:.|:|.::...::   |..|.:.:.|
Yeast   821 LSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSPIEASSSSPDSLTSSY---TPASTHVLIP- 881

Human  1000 QSSSEDREPFSLIEDLQNDL------------LSHSGMLDHSHSPMETSETQFAAGTPCLS---- 1048
                   :|:....|:...|            |.....::.|:|.:.||.:.|.:.:|.|.
Yeast   882 -------QPYKGANDVMRRLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNS 939

Human  1049 --LDLSDSNLDNMEWLDITMPNSSSGLTPLSTTAPSMFSADFLD 1090
              :..|.|..|..|..|||..:           ||.||.:|..|
Yeast   940 KRVVSSTSAADIFEENDITFAD-----------APPMFDSDDSD 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRTFB	NP_001295071.1	RPEL	52..76	CDD:475195
		RPEL	96..119	CDD:460677
		RPEL	139..164	CDD:128947
		PHA03247	<197..410	CDD:223021	52/253 (21%)
		SAP	400..433	CDD:460424	6/35 (17%)
		DUF2130	568..>603	CDD:430914	5/34 (15%)
		SP1-4_N	<649..>826	CDD:425404	38/246 (15%)
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799