Protein Alignment MRTFB and CDC15

DIOPT Version :10

• Sequence 1: NP_001295071.1
• Gene: MRTFB / 57496
• HGNCID: 29819
• Length: 1099
• Species: Homo sapiens
• Sequence 2: NP_009411.2
• Gene: CDC15 / 851274
• SGDID: S000000072
• Length: 974
• Species: Saccharomyces cerevisiae
• Alignment Length: 759
• Identity: 147/759 - (19%)
• Similarity: 246/759 - (32%)
• Gaps: 263/759 - (34%)

Human   416 GLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVST 480
            ||..:.:|..:.:.|...:.::..|:....|.|    |.:..:.:.||.|....:...|.||..|
Yeast   117 GLSENESKTYVTQTLLGLKYLHGEGVIHRDIKA----ANILLSADNTVKLADFGVSTIVNSSALT 177

Human   481 LKAEL----PP-TGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADT----FTEIMTMMSPS 536
            |...|    |. .|...|:.:.::.|   :..:..|..:.:....|:.|.    ..|..|...||
Yeast   178 LAGTLNWMAPEILGNRGASTLSDIWS---LGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPS 239

Human   537 QFLSSSPLRMTNNEDSLS----------PTSSTL---------SNLELDAAEK------------ 570
            .|  |.||:     |.||          ||:..|         .|:::|...|
Yeast   240 SF--SEPLK-----DFLSKCFVKNMYKRPTADQLLKHVWINSTENVKVDKLNKFKEDFTDADYHW 297

Human   571 DRKLQEKEKQIEELKRKL----------EQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGH-- 623
            |...||::..|...|..|          .||..|:...:.||      ..|....::|....|
Yeast   298 DADFQEEKLNISPSKFSLAAAPAAWAENNQELDLMPPTESQL------LSQLKSSSKPLTDLHVL 356

Human   624 -SVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVG 687
             ||.|.:       :|.|  ::.:|.|                    :|.|.|:.:.....:.|.
Yeast   357 FSVCSLE-------NIAD--TIIECLS--------------------RTTVDKRLITAFGSIFVY 392

Human   688 QAE-QQSVVSQFYVSSQGQP---------PPAVVAQPQALL-----------TTQTAQLLLPVSI 731
            ..: ..|.:...:::..|.|         ...|:..||.|:           :.:|.:.:|.:..
Yeast   393 DTQHNHSRLRLKFIAMGGIPLIIKFEHLAKEFVIDYPQTLIECGIMYPPNFASLKTPKYILELVY 457

Human   732 QGSSVTSV---------QLPVGSLKLQTSPQAGMQTQPQIATAAQIPTAALASGLAP-----TVP 782
            :...:||.         .|.: ||.|....:...|:           .....|..||     .:|
Yeast   458 RFYDLTSTAFWCRWCFKHLDI-SLLLNNIHERRAQS-----------ILLKLSSYAPWSFEKILP 510

Human   783 QTQDT-FPQHVLSQPQQVRKVF--------TN-------SASSNTVLPYQRHPAPAVQQPFINKA 831
            ...|: ..:.:|..||....||        ||       :..|::.||....|
Yeast   511 SLIDSKLKKKILISPQITYVVFKSINYMITTNDDKIHKSAIPSSSSLPLSSSP------------ 563

Human   832 SNSVLQSRNAPLPSLQNGPNTP------NKPSSP----------------------PPPQQFVVQ 868
                  :||:|:.|:|:...:|      .:||||                      ..|:.|...
Yeast   564 ------TRNSPVNSVQSPSRSPVHSLMATRPSSPMRHKSISNFPHLTISSKSRLLIELPEGFFTW 622

Human   869 HSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFD-----ILIKSGEISLPIK 928
            .:.|...:|:.||....:...|....|       .:.:|..::||.|     ..|::.:..:|..
Yeast   623 LTSFFVDMAQIKDLSVLKYFTKLCYLT-------VHINSTFLNDLLDNDAFFAFIRNIDTIIPFI 680

Human   929 EEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAF-------- 985
            ::..        ||:.....:..:.      |:|    ||: |..:||||.:....|
Yeast   681 DDAK--------TAAFIWKQITAIC------VEM----SLD-MDQMSASLFSTAMNFIRKKNNTS 726

Human   986 ----------LDGTLPSAN-EIPPLQSSSEDREPFSLIEDLQND 1018
                      |..||.:.| ::.|...|||....| ||: :.||
Yeast   727 ISGLEIILNCLHFTLRNVNDDVAPTVGSSESHSVF-LIK-VNND 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRTFB	NP_001295071.1	RPEL	52..76	CDD:475195
		RPEL	96..119	CDD:460677
		RPEL	139..164	CDD:128947
		PHA03247	<197..410	CDD:223021
		SAP	400..433	CDD:460424	4/16 (25%)
		DUF2130	568..>603	CDD:430914	11/56 (20%)
		SP1-4_N	<649..>826	CDD:425404	37/227 (16%)
CDC15	NP_009411.2	Protein Kinases, catalytic domain	24..272	CDD:473864	38/168 (23%)