Protein Alignment MRTFB and pqn-62

DIOPT Version :10

• Sequence 1: NP_001295071.1
• Gene: MRTFB / 57496
• HGNCID: 29819
• Length: 1099
• Species: Homo sapiens
• Sequence 2: NP_001300375.1
• Gene: pqn-62 / 180789
• WormBaseID: WBGene00004145
• Length: 1321
• Species: Caenorhabditis elegans
• Alignment Length: 1330
• Identity: 233/1330 - (17%)
• Similarity: 438/1330 - (32%)
• Gaps: 422/1330 - (31%)

Human    14 GPLAHLAPSPQSEAV-AHEFQELSLQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKS 77
            ||  |..||..|..: .|..:..:.....:....|::|:.:...|.|.....|:..:.:|...::
 Worm    49 GP--HQRPSNGSNNLEQHAMRPATTGGDPSNRVFNDQKSSIDGSLHQGSNSNQMTQESMMSLQQN 111

Human    78 PAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQAT-------QMKLKRA 135
            |...|..       ::...:.:.:.|......|..:.:.:.::   |:.:|       |.:|::.
 Worm   112 PMQQHHH-------QSNQMVSYNLVSEDSSVRLPPLTLNDRSY---SISSTVHLSNGLQCQLQQN 166

Human   136 RLAD-----------DLNEKIAQ-------RPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQ 182
            .|.|           |.|:.:::       ||..||...::...:||        :...|.|. |
 Worm   167 ELTDNTHQSSQVNQCDYNQNMSEQSEQPILRPSRMESTNQSHQNIDS--------MYHIDQPQ-Q 222

Human   183 GDFSFD-EDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTP 246
            ..|..: ::.|:.:....|.:..:..:..|..:|.:|.:    :|...:.|.:.:..:|.|...|
 Worm   223 VVFQANLQNRSNRVMQQTPNNSSNHQNHLSLKQPHLSMN----STQLQSGFQTGNRMMPSFQVNP 283

Human   247 PT---------ADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKK 302
            .|         .|||||...:    .|::|.::..|:.:.|            ..|...:..|:
 Worm   284 TTQDQVPHLSHMDQPPPTQHS----MNSISQSQQHPSQLSQ------------LSCNSNQMSVQ- 331

Human   303 LKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK---PLND 364
               :..:.|..........|.||               .:|.........:|||:...   |:|.
 Worm   332 ---NHVLSPSSTNSNMSLNMRSN---------------SISSSSSSPIKNSILPSTSPCTIPMNA 378

Human   365 KNSNSGNSALNNATPNTPR-----QNTST-------------PVRKPGPLPSSLDDLKVSELKTE 411
            .::.....||||.:|.|..     ||.:|             |..|..|   |:.::..::|::.
 Worm   379 NSTTQLLMALNNNSPITSEQLQEIQNMTTISADGTEILLMQEPRLKQYP---SIAEMCTTDLRSA 440

Human   412 LKLRGLPVSGTKPDLIERLKPY-----QEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLH 471
            .|.|.||.:|.||.|.|||:.:     :|.|...:.                       ..|..|
 Worm   441 CKKRSLPHTGPKPRLCERLRGHENEVLEERNRQNMK-----------------------EYTDRH 482

Human   472 NTVTSSVSTLKA-----------ELPPTGTSN--------------------ATRVE-------- 497
            ....:..:||||           ..|..||||                    :|.||
 Worm   483 QMYEAQAATLKAYQAKKALLQVQSSPDMGTSNVYGARSNSSQCISSNENSMSSTSVEGPPAKKKR 547

Human   498 ----------NVHSPLPISPSPSEQSSLSTDDTNMADTFTE-IMTMMSPSQFLSSSPLR----MT 547
                      .:.....|:.:|....::..|..|...|.|. |.|:::.:..:..|..:    |.
 Worm   548 ISKPKKALQSRLEKQTTITVAPQNSLTIPADSCNQGSTTTNAIRTLVNNTNLMGGSNTQNGNTMV 612

Human   548 NNEDSLSPTSSTLSNLE-----------------------LDAAEKD------------------ 571
            |.:.|.:.:|:...::.                       :.|:..|
 Worm   613 NGQSSQNSSSNFFGDMNQTGTGFFMKDNSCFSHLGSGCRLISASSNDDSQNTFGGTGRAFQAAVP 677

Human   572 ------------------------RKLQEKEKQIEELKRKLEQEQKLVE---------VLKMQLE 603
                                    ..:.::::||.:.:.....:|:::|         :..:...
 Worm   678 PPPENSQLQFQNFGMTETIPQQSNEHVSQQQQQIAQSRPMNLNQQQVIETPVNQSISNIFNISTA 742

Human   604 VEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSS--IKDEA----SLP--DCSSSRQPIPVASHA 660
            ...:.|||:.::.||....:.:.|......|.:|  :.|:|    |:|  |..::....||...|
 Worm   743 NTMQQQQQQNVQQQPQQQPNFINSSMAQNGLQASPCVADQAGPSPSMPVSDPIATTSGSPVVVSA 807

Human   661 VGQPVSTGGQ--------------TLVAKKAVVIKQEVPVGQ------------AEQQSVVSQFY 699
            |.:..|...:              ||.|::.::.:|:..:.:            .|||..::...
 Worm   808 VAESTSESAELMDLETMQNLLSPATLRAREDLLTQQQAKINELVKLIQKNHDTLREQQQQINLAK 872

Human   700 VSSQGQPPPAVVAQP-----------QALLTTQTAQLLLPVSIQGSSVTSVQLP-VGSLKLQTS- 751
            ...:.:....|.:.|           .|:.:.|..|::..::.|..|:.:.:.. :..|.:.|:
 Worm   873 KQQKQRQRQNVPSAPLDKHVNSRCIQHAIKSRQNFQMINELTTQQDSIRTAETRLIEQLHINTAT 937

Human   752 -------PQAGMQT--------------------------QPQIA--TAAQIPTAALASGLAPTV 781
                   .|.|...                          ||.:|  ||.:: |...|.......
 Worm   938 DDIARLIKQDGRTALVIVSLLHDYRTTREQNNRAKSTTGEQPVVADSTAVEV-TKKKAPARKRNA 1001

Human   782 PQTQDTFPQHVLSQPQQV--RKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLP 844
            ..|..|.|....:|.:|.  ..|....:|:|.    |:.|....||.  |:..||..|....
 Worm  1002 NGTTKTAPSKKTAQQKQAVDNDVIQIISSTNE----QKIPVEQSQQQ--NQQQNSQKQFLEF--- 1057

Human   845 SLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQ 909
               :.|:.|.:.||    |..|...::|.:.:    |..|.::...||:..|.|       ..||
 Worm  1058 ---HHPHVPQRVSS----QSDVDMEAIFKTVI----DASRSQQKESQTKQQQQP-------QQQQ 1104

Human   910 MDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGSL 974
            .|:  :::....|:|.|::.:              :...|.:|.|.......||......|. .:
 Worm  1105 YDN--EVISLPSEVSSPMRTQ--------------SQNSVQSVFSDGSYSRNMAFQQENSPQ-EI 1152

Human   975 SASLENQLEAFLDGTLPSANEIPPLQSS------SEDREPFSLIEDLQNDLLSHSGMLDHSHSPM 1033
            :.|:.|..|:    .....|| .|||:|      |:..:...::.....::::|.  ::..||.|
 Worm  1153 TYSMSNGAES----NTSQQNE-SPLQNSQHSEVVSKQSDIVEILPQFDQNVMNHD--VNQFHSNM 1210

Human  1034 ---ETSETQF-AAGTPCLSLDLSDSNLDNM 1059
               |.|..:| |..:....||....::|.|
 Worm  1211 IYNEDSNQEFIAQNSQTHDLDFDFPDIDQM 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRTFB	NP_001295071.1	RPEL	52..76	CDD:475195	4/23 (17%)
		RPEL	96..119	CDD:460677	2/22 (9%)
		RPEL	139..164	CDD:128947	7/42 (17%)
		PHA03247	<197..410	CDD:223021	45/242 (19%)
		SAP	400..433	CDD:460424	12/32 (38%)
		DUF2130	568..>603	CDD:430914	5/85 (6%)
		SP1-4_N	<649..>826	CDD:425404	41/252 (16%)
pqn-62	NP_001300375.1	PAT1	<174..>322	CDD:401645	32/176 (18%)
		SAP	435..463	CDD:460424	12/27 (44%)