DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF150 and APE3

DIOPT Version :9

Sequence 1:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	132	Identity:	30/132 - (22%)
Similarity:	52/132 - (39%)	Gaps:	29/132 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   100 LACDPN--TKFAAPTRGKNWIALIPKGNCTYRDKIRNAFLQNASAVVIFNVGSNTNETITMPHAG 162
            |.|:..  .....|...:..||||.:|.|.:.||...|.....:||||::....:.|       |
Yeast   185 LGCEEKDYASVVPPRHNEKQIALIERGKCPFGDKSNLAGKFGFTAVVIYDNEPKSKE-------G 242

Human   163 LMSSHAQPLKLISPCPYSLSSGVEDIVAIMIPEPKGKEIVSLLERNITVTMYIT-------IGTR 220
            |..:..:|.|             ..:..:.:|...||::::.:..||..::|..       |.|:
Yeast   243 LHGTLGEPTK-------------HTVATVGVPYKVGKKLIANIALNIDYSLYFAMDSYVEFIKTQ 294

Human   221 NL 222
            |:
Yeast   295 NI 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	26/116 (22%)
		UPF0233	<229..>254	CDD:299753
		zf-RING_2	298..341	CDD:290367
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	30/132 (23%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045	27/118 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910