DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF150 and rnf150a

DIOPT Version :9

Sequence 1:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens
Sequence 2:	NP_001139044.1	Gene:	rnf150a / 559804	ZFINID:	ZDB-GENE-060213-1	Length:	418	Species:	Danio rerio

Alignment Length:	462	Identity:	301/462 - (65%)
Similarity:	350/462 - (75%)	Gaps:	46/462 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAMSLIQACCSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYAEPAPDPGAGAAGGGGA 65
            |.:||.|||.||||||||||||||||||||||||||||||||||||||.:|..           :
Zfish     1 MVVSLTQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYLDPVT-----------S 54

Human    66 ELHTEKTECGRYGEHSPKQDARGEVVMASSAHDRLACDPNTKFAAPTRGKNWIALIPKGNCTYRD 130
            |:.|:::|||||||||||:||||.|.|   ..||.|||.||:|..|.....|||||.|||||:|:
Zfish    55 EIKTDRSECGRYGEHSPKRDARGFVFM---PQDRQACDGNTRFPLPHPSIPWIALIAKGNCTFRE 116

Human   131 KIRNAFLQNASAVVIFNVG-SNTNETITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIP 194
            |||:|...||||||||||| ||:|:||||||                      .|..|:||||||
Zfish   117 KIRHAAALNASAVVIFNVGSSNSNDTITMPH----------------------HGTGDVVAIMIP 159

Human   195 EPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 259
            ||||:||::|||:||||.|:|:|||||||||||||||||||||||||||||||||||||||||||
Zfish   160 EPKGREIMALLEKNITVAMHISIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 224

Human   260 ANARDRNQRRLGDAAKKAISKLQIRTIKKGDKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHK 324
            ||||||:||||||||||||||||:|||:||||||:|||||||||||.||||||||||||||:||:
Zfish   225 ANARDRSQRRLGDAAKKAISKLQVRTIRKGDKETDSDFDNCAVCIEDYKPNDVVRILPCRHVFHR 289

Human   325 SCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPTDFEGSLGGPPTNQITGASDTTVNESSV 389
            :||||||.|||||||||||||||||||||.||.||.|.|:|.| .|.|:..:||||:.:|.|||:
Zfish   290 NCVDPWLQDHRTCPMCKMNILKALGIPPNTDCSDDAPPDYETS-SGQPSIAVTGASEVSVGESSL 353

Human   390 TLDPAVRTVGALQVVQDTDPIPQEGDVIFTTNSEQ-EPAVSSDSDISLIMAMEVGLSDVELSTDQ 453
            .||..:|..|.....|:.:.:|.:.:.....:||| :|::|:|.|   ||.||:    .||.:|.
Zfish   354 VLDQPLRITGLSHDYQEMNSVPADAESPHIASSEQHQPSMSNDPD---IMPMEI----AELQSDL 411

Human   454 DCEEVKS 460
            :.|:|||
Zfish   412 EQEDVKS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	90/170 (53%)
		UPF0233	<229..>254	CDD:299753	24/24 (100%)
		zf-RING_2	298..341	CDD:290367	37/42 (88%)
rnf150a	NP_001139044.1	PA_GRAIL_like	45..180	CDD:239037	90/170 (53%)
		UPF0233	<194..>219	CDD:299753	24/24 (100%)
		zf-RING_2	263..306	CDD:290367	37/42 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194328009
Domainoid	1	1.000	92	1.000	Domainoid score	I27660
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33783
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto42135
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.250