Protein Alignment RNF150 and gzl

DIOPT Version :10

• Sequence 1: XP_005263207.1
• Gene: RNF150 / 57484
• HGNCID: 23138
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_649653.1
• Gene: gzl / 40791
• FlyBaseID: FBgn0037442
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 83/332 - (25%)
• Similarity: 139/332 - (41%)
• Gaps: 79/332 - (23%)

Human    76 RYGEHSPKQDARGEVVMASSAH---DRLACDPNTKFAAPTRGKNWIALIPKGNCTYRDKIRNAFL 137
            ::|.:.|....:..||.|...:   |.|...|:.|:  |...| ::||:.:|.|.:..|||.|
  Fly    48 QFGPNLPSNGLKVYVVPARRPYYGCDSLDRPPHLKY--PPSAK-FVALVARGECVFERKIRVA-- 107

Human   138 QNA--SAVVIFNVGSNTNETITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIP-----E 195
            |||  |||:::|     ||             ...|:.:|         .|:|..|.||     .
  Fly   108 QNASYSAVIVYN-----NE-------------GDDLEQMS---------AENITGIRIPSVFVGH 145

Human   196 PKGKEIVSLLERNITVTMYITIGTR---NLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRF 257
            ..||.:.:.    .|..:.:.|...   |:...:.....:.:.:.||:::|    ::::..|
  Fly   146 TTGKALATY----FTTEVVLIINDELPFNINTQLILPFSILIGMCFIIMVI----YMIYKCI--- 199

Human   258 RYANARDRNQRRL--GDAAKKAISKLQIRTIKKGDKETESDFDNCAVCIEGYKPNDVVRILPCRH 320
                   |.||||  ....|..:.||.:....|.:  ..:.:|.|.:|:|.:..:|.:|:|||.|
  Fly   200 -------REQRRLRRHRLPKSMLKKLPVLRYTKNN--ANNKYDTCVICLEDFIEDDKLRVLPCSH 255

Human   321 LFHKSCVDPWLLDH-RTCPMCKMNIL------KALGIPPNADCMDDLPTDFEGSL-----GGPPT 373
            .:|..|:||||.:: |.||:||..:.      .:....|:.|.:.|...|....|     .|...
  Fly   256 PYHTHCIDPWLTENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQV 320

Human   374 NQITGAS 380
            .|::.||
  Fly   321 GQVSSAS 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	38/148 (26%)
		RING-H2_RNF150	292..346	CDD:438456	21/60 (35%)
		HRD1	<300..433	CDD:227568	29/93 (31%)
gzl	NP_649653.1	PA_C_RZF_like	14..171	CDD:239038	39/158 (25%)
		RING-H2_RNF13-like	233..278	CDD:438327	20/44 (45%)