DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF150 and H10E21.5

DIOPT Version :9

Sequence 1:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	423	Identity:	132/423 - (31%)
Similarity:	190/423 - (44%)	Gaps:	135/423 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    24 VHLLCLDFTVAEKEEWY-TAFVNITYAEPAPDPGAGAAGGGGAELHTEKTECGRYGEHSPKQDAR 87
            |.|.|:|     .||.| |....:|::.         ..|||:......|:
Worm    30 VKLQCID-----SEEVYGTLQTELTFSN---------KDGGGSTFLPAYTD-------------- 66

Human    88 GEVVMASSAHDRLACDPNTKFAAPTR---GKNWIALIPKGNCTYRDKIRNAFLQNA--SAVVIFN 147
                         .|.|:.||....|   .||.|.     ||..|       ::.|  :.:::.:
Worm    67 -------------LCAPDMKFDDSQRVFFCKNCIQ-----NCLSR-------VETAPKNILIVAD 106

Human   148 VGSNTNET----ITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIPEPKGKEIVSLLERN 208
            |.:..|..    :..|.:.:..|..|       |      .||:..|:..||....:.:
Worm   107 VKAPNNRVSWFHVQTPVSNIRESGKQ-------C------NVENSNAMQSPEETSTDAL------ 152

Human   209 ITVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDA 273
                           :..|:|||:|||||||:||:||||||||||:||||||:|:||.||||.:|
Worm   153 ---------------RSFSKTSVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNA 202

Human   274 AKKAISKLQIRTIKKG-DKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTC 337
            |:||::::...||..| .:|.:||   ||||::.|:..||:|:|||:|::||||:|||||:||||
Worm   203 ARKALTRIPTMTITPGMTQELQSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTC 264

Human   338 PMCKMNILKALGIPPNADCMDDLPTDFEGSLGGPPTNQITGASDTTVNESSVTLDPAVRTVGALQ 402
            ||||.:|||..|.      .:|:..|.:     .|||....|.|.|:.               |:
Worm   265 PMCKNDILKHFGY------WNDIRNDIQ-----MPTNSRGIADDFTIR---------------LE 303

Human   403 VVQDTDPIPQEGDVIFTTNSEQEPAVSSDSDIS 435
            :.:.....| ..|||       .|..:||:..|
Worm   304 LGEQEHQAP-SADVI-------SPEANSDTSDS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	28/178 (16%)
		UPF0233	<229..>254	CDD:299753	21/24 (88%)
		zf-RING_2	298..341	CDD:290367	27/42 (64%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	94/232 (41%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	31/49 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452848
Domainoid	1	1.000	84	1.000	Domainoid score	I5756
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3321
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm15229
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.680