DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF150 and rnf150

DIOPT Version :9

Sequence 1:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens
Sequence 2:	NP_001135553.1	Gene:	rnf150 / 100216098	XenbaseID:	XB-GENE-5993052	Length:	427	Species:	Xenopus tropicalis

Alignment Length:	461	Identity:	359/461 - (77%)
Similarity:	389/461 - (84%)	Gaps:	35/461 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAMSLIQACCSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYAEPAPDPGAGAAGGGGA 65
            |||||||||.||||||||||||||||||||||||||||||||||||||.:|.           ..
Frog     1 MAMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYTDPL-----------SH 54

Human    66 ELHTEKTECGRYGEHSPKQDARGEVVMASSAHDRLACDPNTKFAAPTRGKNWIALIPKGNCTYRD 130
            :..|||:|||||||||.||||.|..||.||..|||||||.|||:.|.....|:||||||||||||
Frog    55 QWRTEKSECGRYGEHSLKQDAWGLAVMPSSPQDRLACDPATKFSVPANASRWVALIPKGNCTYRD 119

Human   131 KIRNAFLQNASAVVIFNVG-SNTNETITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIP 194
            ||::|.|||||||:|:||| ||.||||||||                      .|:|||||||||
Frog   120 KIKHAALQNASAVLIYNVGSSNANETITMPH----------------------PGIEDIVAIMIP 162

Human   195 EPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 259
            ||||:||.:||||||.||:||||||||||||||||||||||||||||||||||||||||||||||
Frog   163 EPKGREIATLLERNINVTIYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 227

Human   260 ANARDRNQRRLGDAAKKAISKLQIRTIKKGDKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHK 324
            |||||||||||||||||||||||:|||||||||||.:||||||||||||||||||||||||||||
Frog   228 ANARDRNQRRLGDAAKKAISKLQVRTIKKGDKETEPEFDNCAVCIEGYKPNDVVRILPCRHLFHK 292

Human   325 SCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPTDFEGSLGGPPTNQITGASDTTVNESSV 389
            ||||||||||||||||||||||||||||||||:||:|.|||||: ||||||||||||.|||||||
Frog   293 SCVDPWLLDHRTCPMCKMNILKALGIPPNADCLDDIPPDFEGSV-GPPTNQITGASDVTVNESSV 356

Human   390 TLDPAVRTVGALQVVQDTDPIPQEGDVIFTTNSEQEPAVSSDSDISLIMAMEVGLSDVELSTDQD 454
            .:||:|||||.|||:||.:.:||.|:|.:|.:||||||||||||||||||::||||||:||||||
Frog   357 GIDPSVRTVGVLQVIQDAESLPQVGEVSYTASSEQEPAVSSDSDISLIMAVDVGLSDVDLSTDQD 421

Human   455 CEEVKS 460
            |:|.||
Frog   422 CDEAKS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	98/170 (58%)
		UPF0233	<229..>254	CDD:299753	24/24 (100%)
		zf-RING_2	298..341	CDD:290367	42/42 (100%)
rnf150	NP_001135553.1	PA_GRAIL_like	45..183	CDD:239037	98/170 (58%)
		UPF0233	<197..>222	CDD:299753	24/24 (100%)
		zf-RING_2	266..309	CDD:290367	42/42 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I16291
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33783
Inparanoid	1	1.050	725	1.000	Inparanoid score	I5115
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto154702
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110