DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLEKHH1 and max-1

DIOPT Version :9

Sequence 1:XP_011535311.1 Gene:PLEKHH1 / 57475 HGNCID:17733 Length:1392 Species:Homo sapiens
Sequence 2:NP_001367137.1 Gene:max-1 / 179794 WormBaseID:WBGene00003143 Length:1099 Species:Caenorhabditis elegans


Alignment Length:1317 Identity:355/1317 - (26%)
Similarity:558/1317 - (42%) Gaps:287/1317 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   116 MRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV 180
            :|:.|.:.:..|:::|:.|||.::.:||.:|:.|::.|.|...|:..|:...|     .|||:  
 Worm     9 LRSPEDEELLAKSSRIRLWVTKRMKELEDQNERLRAQNLRCTTQLQMLRSFTE-----KSRKI-- 66

Human   181 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVH 245
                .||.:...|..|..|:.:|....:          ....|.|.|:         |....:|.
 Worm    67 ----KAEMEMSRSITGTLPVLRDENRTS----------DDSGLTSDDA---------DRKQMSVS 108

Human   246 SGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTK--TSAREGGP-- 306
            ..|..      |.:.|:                          |.|.||..|.  :|..|..|  
 Worm   109 ISECT------PRVQRK--------------------------AARTMLKNTSQGSSTSESSPCE 141

Human   307 --GSSLTLP-KVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRA 368
              ...:.|| ::....|.|||                                       |.|.|
 Worm   142 DEAKPMPLPRRIHPTATERDS---------------------------------------LNSYA 167

Human   369 RSRE---EPEKMEMEEPPPAGKNEER------------ESPKALGAELEEVELGNKP--PTPPLH 416
            ...|   |....|..|.....:||:.            :..|.:.:|:.:.....|.  |..|.|
 Worm   168 EDYEYDIEESSFERHEEQVRNENEKYVDYVNLHEFVAIKDDKVVYSEIVKHRSTEKEYLPALPSH 232

Human   417 QFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRAT 481
            |...||:|:...|...:.:.|.:....|:...|..|..||  ..|.:...|.|            
 Worm   233 QPRQWENRLIQAAEKCLSVIDGADSEGTSTGPSVSPYHVS--DVSRISSNNRT------------ 283

Human   482 QISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPD 546
                     ||.||........:....|||..|.:.   |:..||:      .|....||.:|||
 Worm   284 ---------ESPGSRKSSKLSRNSSPRVPSHHSYED---GAAYAIR------DLCLGSDYYLPPD 330

Human   547 A---CSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKM-GSQVKTWKRRWFVLRQGQI 607
            |   ||..:..|       |||      |....|::|||||..:: .|::|:.|||:.|.:.|||
 Worm   331 ASSRCSGGTPTS-------RTS------LIPSRETMEKSGYWTQLTDSRIKSLKRRYVVFKNGQI 382

Human   608 MYYKSPSDVIRKPQGQV---DLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQS 669
            .:|:..::...:|..::   |:.|..::.:...:..||||:.........:|.....:|:.:|.:
 Worm   383 SFYRKHNNRDEEPASKISISDIRSVTKLEQQGAAYAFQLITSTDKMNFMTESERTTHDWVTILSA 447

Human   670 LLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKLHGAYVFRERR 734
            .:|.......|........::.||||:||.|.||.|:.|||.:...::::..|.:          
 Worm   448 AIKATTLREMASRVTPIDASISGWLTRVKCGLSKKVFAALVNQKLMFFKNSNDLV---------- 502

Human   735 LPHPPLALPFMEDCCPQRPLGCLPVRDAHIEE-----VDRSCDSDEDYEA----GGTRRLLSSHC 790
                              |.|.|.::.|.|.|     .:.|..|||..|.    ...|:...|.|
 Worm   503 ------------------PNGFLCLQGAQISEKHNGTEEYSGSSDEQLETTKEHPNQRKNNDSLC 549

Human   791 TLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRH 855
            ..:   ....|.||::.|..:|:.|||:|. :|.|::|..||.:|.|:.::|......|||||  
 Worm   550 VQI---ANEDPVYLILRTSEDKEKWLYYLK-SASGTAALCGTPFEILVQRMMAENVANDSPLW-- 608

Human   856 PMLCYSKDGLYASLTTLPSEAL-------QTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQ 913
                  ||.|:||...:|.:.:       :.:.|::.::||||::|.:.|.:..||:.|||..|.
 Worm   609 ------KDLLFASGEEIPKDTMTSVDHSDRKKTLEIARACQLFVSVLMRAQATQYHIDLAQNILS 667

Human   914 VCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLP-QHHFLWYVKQQLQRHADP 977
            ..:....|::|:|.||:|.||...|  :.| |.|:||||..||||| |:..||.:|:.:.|..|.
 Worm   668 TAVQQEYLRNEVYSQLIKMTSGSMP--FGL-QGWKLLALTIPLFLPKQYSLLWLLKRHISRWVDL 729

Human   978 RSETGQ--YATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVG 1040
            .:|:.:  .|.:|:.|::|.||.|.|:..|||:||.|:|.|:......|.||.|...|..|.:|.
 Worm   730 PNESDETRMAIFCESALDRCLRVGGRQEGPSRLEVTSVLTRDVTRTKFPHSISVKLPNSEYQIVE 794

Human  1041 FDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELH 1105
            ||||:.:.:.|..|..::|||....||:||:.:||....| ..|:|..|:|||:|.||...::..
 Worm   795 FDGSTEIGQCLSSLCLKLGMRPALLSGYALYMNDPMTHSL-LLLKGKQKLCDALSTWETRSRDAQ 858

Human  1106 PGKSEGGTRVVK-----LMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMA 1165
            .|      ||:.     |..:.|.|:......||..||..|..:.|.|||.||.|::.:|...:|
 Worm   859 RG------RVISDCAAALSLRMRHYWGHLALTETPIERQFLVWRASEEIVNGRIPLSNQLCESLA 917

Human  1166 ALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKWAT 1230
            ||.||:.:||           .:.:.:....:.:..||:|.:....|..:.||.   .:.:.|:.
 Worm   918 ALYAQMVFGD-----------ANQSLSDQQFEFISQRFYPSKMLDVACIKSLRL---QINSNWSE 968

Human  1231 LQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHIT 1295
            |.|.|..||:|:.|.|..|||.||:.|   ..|.:.:.....:::|:|:..||:||.....|..|
 Worm   969 LIGMSENECVRVILQVLGKWPLFGSDL---HEASMRTDNERKIYLALNDHSVSLLDRRHFDVIRT 1030

Human  1296 YPYSSVTTFGGCRDDFML-VIRSI-PDKSSGKSHIEKLIFRMAAPKIAEATFIMASYMNHCTTTV 1358
            .||||::|||..:.|||| :||.: |.....::..|:|.|.|...:|.:.|..:|.|:.      
 Worm  1031 IPYSSLSTFGQFQQDFMLTIIRPLTPGSHPDEAPKERLTFSMQKNEIEQLTLHLAEYIR------ 1089

Human  1359 NPPTNPPGACQ--LWEL 1373
                     ||  :|::
 Worm  1090 ---------CQKLVWKV 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLEKHH1XP_011535311.1 flagell_FliJ 27..164 CDD:131526 14/47 (30%)
FlgN 31..186 CDD:298847 19/69 (28%)
PH 579..672 CDD:278594 25/96 (26%)
PH1_PLEKHH1_PLEKHH2 581..676 CDD:241436 25/98 (26%)
MyTH4 860..1014 CDD:214535 61/163 (37%)
B41 1027..1258 CDD:214604 76/235 (32%)
FERM_M 1130..1258 CDD:278785 40/127 (31%)
FERM_C-lobe_PLEKHH1_PLEKHH2 1254..1356 CDD:241360 33/103 (32%)
max-1NP_001367137.1 PH 353..450 CDD:214574 25/96 (26%)
PH 468..579 CDD:214574 37/142 (26%)
MyTH4 662..766 CDD:395633 44/106 (42%)
B41 781..996 CDD:214604 77/238 (32%)
PH-like 992..1088 CDD:418428 32/98 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 98 1.000 Domainoid score I4953
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H121939
Inparanoid 1 1.050 399 1.000 Inparanoid score I1240
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48143at33208
OrthoFinder 1 1.000 - - FOG0004352
OrthoInspector 1 1.000 - - otm14947
orthoMCL 1 0.900 - - OOG6_106231
Panther 1 1.100 - - LDO PTHR22903
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3701
SonicParanoid 1 1.000 - - X3070
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.000

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