Protein Alignment PLEKHH1 and max-1

DIOPT Version :10

• Sequence 1: XP_011535311.1
• Gene: PLEKHH1 / 57475
• HGNCID: 17733
• Length: 1392
• Species: Homo sapiens
• Sequence 2: NP_001367137.1
• Gene: max-1 / 179794
• WormBaseID: WBGene00003143
• Length: 1099
• Species: Caenorhabditis elegans
• Alignment Length: 1317
• Identity: 355/1317 - (26%)
• Similarity: 558/1317 - (42%)
• Gaps: 287/1317 - (21%)

Human   116 MRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV 180
            :|:.|.:.:..|:::|:.|||.::.:||.:|:.|::.|.|...|:..|:...|     .|||:
 Worm     9 LRSPEDEELLAKSSRIRLWVTKRMKELEDQNERLRAQNLRCTTQLQMLRSFTE-----KSRKI-- 66

Human   181 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVH 245
                .||.:...|..|..|:.:|....:          ....|.|.|:         |....:|.
 Worm    67 ----KAEMEMSRSITGTLPVLRDENRTS----------DDSGLTSDDA---------DRKQMSVS 108

Human   246 SGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTK--TSAREGGP-- 306
            ..|..      |.:.|:                          |.|.||..|.  :|..|..|
 Worm   109 ISECT------PRVQRK--------------------------AARTMLKNTSQGSSTSESSPCE 141

Human   307 --GSSLTLP-KVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRA 368
              ...:.|| ::....|.|||                                       |.|.|
 Worm   142 DEAKPMPLPRRIHPTATERDS---------------------------------------LNSYA 167

Human   369 RSRE---EPEKMEMEEPPPAGKNEER------------ESPKALGAELEEVELGNKP--PTPPLH 416
            ...|   |....|..|.....:||:.            :..|.:.:|:.:.....|.  |..|.|
 Worm   168 EDYEYDIEESSFERHEEQVRNENEKYVDYVNLHEFVAIKDDKVVYSEIVKHRSTEKEYLPALPSH 232

Human   417 QFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRAT 481
            |...||:|:...|...:.:.|.:....|:...|..|..||  ..|.:...|.|
 Worm   233 QPRQWENRLIQAAEKCLSVIDGADSEGTSTGPSVSPYHVS--DVSRISSNNRT------------ 283

Human   482 QISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPD 546
                     ||.||........:....|||..|.:.   |:..||:      .|....||.:|||
 Worm   284 ---------ESPGSRKSSKLSRNSSPRVPSHHSYED---GAAYAIR------DLCLGSDYYLPPD 330

Human   547 A---CSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKM-GSQVKTWKRRWFVLRQGQI 607
            |   ||..:..|       |||      |....|::|||||..:: .|::|:.|||:.|.:.|||
 Worm   331 ASSRCSGGTPTS-------RTS------LIPSRETMEKSGYWTQLTDSRIKSLKRRYVVFKNGQI 382

Human   608 MYYKSPSDVIRKPQGQV---DLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQS 669
            .:|:..::...:|..::   |:.|..::.:...:..||||:.........:|.....:|:.:|.:
 Worm   383 SFYRKHNNRDEEPASKISISDIRSVTKLEQQGAAYAFQLITSTDKMNFMTESERTTHDWVTILSA 447

Human   670 LLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKLHGAYVFRERR 734
            .:|.......|........::.||||:||.|.||.|:.|||.:...::::..|.:
 Worm   448 AIKATTLREMASRVTPIDASISGWLTRVKCGLSKKVFAALVNQKLMFFKNSNDLV---------- 502

Human   735 LPHPPLALPFMEDCCPQRPLGCLPVRDAHIEE-----VDRSCDSDEDYEA----GGTRRLLSSHC 790
                              |.|.|.::.|.|.|     .:.|..|||..|.    ...|:...|.|
 Worm   503 ------------------PNGFLCLQGAQISEKHNGTEEYSGSSDEQLETTKEHPNQRKNNDSLC 549

Human   791 TLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRH 855
            ..:   ....|.||::.|..:|:.|||:|. :|.|::|..||.:|.|:.::|......|||||
 Worm   550 VQI---ANEDPVYLILRTSEDKEKWLYYLK-SASGTAALCGTPFEILVQRMMAENVANDSPLW-- 608

Human   856 PMLCYSKDGLYASLTTLPSEAL-------QTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQ 913
                  ||.|:||...:|.:.:       :.:.|::.::||||::|.:.|.:..||:.|||..|.
 Worm   609 ------KDLLFASGEEIPKDTMTSVDHSDRKKTLEIARACQLFVSVLMRAQATQYHIDLAQNILS 667

Human   914 VCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLP-QHHFLWYVKQQLQRHADP 977
            ..:....|::|:|.||:|.||...|  :.| |.|:||||..||||| |:..||.:|:.:.|..|.
 Worm   668 TAVQQEYLRNEVYSQLIKMTSGSMP--FGL-QGWKLLALTIPLFLPKQYSLLWLLKRHISRWVDL 729

Human   978 RSETGQ--YATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVG 1040
            .:|:.:  .|.:|:.|::|.||.|.|:..|||:||.|:|.|:......|.||.|...|..|.:|.
 Worm   730 PNESDETRMAIFCESALDRCLRVGGRQEGPSRLEVTSVLTRDVTRTKFPHSISVKLPNSEYQIVE 794

Human  1041 FDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELH 1105
            ||||:.:.:.|..|..::|||....||:||:.:||....| ..|:|..|:|||:|.||...::..
 Worm   795 FDGSTEIGQCLSSLCLKLGMRPALLSGYALYMNDPMTHSL-LLLKGKQKLCDALSTWETRSRDAQ 858

Human  1106 PGKSEGGTRVVK-----LMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMA 1165
            .|      ||:.     |..:.|.|:......||..||..|..:.|.|||.||.|::.:|...:|
 Worm   859 RG------RVISDCAAALSLRMRHYWGHLALTETPIERQFLVWRASEEIVNGRIPLSNQLCESLA 917

Human  1166 ALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKWAT 1230
            ||.||:.:||           .:.:.:....:.:..||:|.:....|..:.||.   .:.:.|:.
 Worm   918 ALYAQMVFGD-----------ANQSLSDQQFEFISQRFYPSKMLDVACIKSLRL---QINSNWSE 968

Human  1231 LQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHIT 1295
            |.|.|..||:|:.|.|..|||.||:.|   ..|.:.:.....:::|:|:..||:||.....|..|
 Worm   969 LIGMSENECVRVILQVLGKWPLFGSDL---HEASMRTDNERKIYLALNDHSVSLLDRRHFDVIRT 1030

Human  1296 YPYSSVTTFGGCRDDFML-VIRSI-PDKSSGKSHIEKLIFRMAAPKIAEATFIMASYMNHCTTTV 1358
            .||||::|||..:.|||| :||.: |.....::..|:|.|.|...:|.:.|..:|.|:.
 Worm  1031 IPYSSLSTFGQFQQDFMLTIIRPLTPGSHPDEAPKERLTFSMQKNEIEQLTLHLAEYIR------ 1089

Human  1359 NPPTNPPGACQ--LWEL 1373
                     ||  :|::
 Worm  1090 ---------CQKLVWKV 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHH1	XP_011535311.1	DR0291	20..>171	CDD:441187	16/54 (30%)
		PH1_PLEKHH1_PLEKHH2	581..676	CDD:241436	25/98 (26%)
		MyTH4	860..1014	CDD:214535	61/163 (37%)
		Ubl1_cv_Nsp3_N-like	1024..1130	CDD:475130	38/110 (35%)
		B41	1027..1258	CDD:214604	76/235 (32%)
		FERM_C-lobe_PLEKHH1_PLEKHH2	1254..1356	CDD:241360	33/103 (32%)
max-1	NP_001367137.1	PH	353..450	CDD:214574	25/96 (26%)
		PH	468..579	CDD:214574	37/142 (26%)
		MyTH4	662..766	CDD:459939	44/106 (42%)
		B41	781..996	CDD:214604	77/238 (32%)
		PH-like	992..1088	CDD:473070	32/98 (33%)