DRSC/TRiP Functional Genomics Resources

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Protein Alignment CNOT6 and twin

DIOPT Version :9

Sequence 1:NP_001357401.1 Gene:CNOT6 / 57472 HGNCID:14099 Length:557 Species:Homo sapiens
Sequence 2:NP_732964.1 Gene:twin / 42880 FlyBaseID:FBgn0011725 Length:567 Species:Drosophila melanogaster


Alignment Length:539 Identity:310/539 - (57%)
Similarity:395/539 - (73%) Gaps:14/539 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     3 KEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIP 67
            |:||:..: ||....:|.|:.|.|||::|:.|||:|.||::|.|||...|||||:|:||.|.|:|
  Fly    27 KDKYDSAN-RRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALYLNDNQLLRLP 90

Human    68 SDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
            :|:..|.:|..|||||||:||||||||.::.||||.||||.|||||:|:||||.|..|||.||||
  Fly    91 ADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELLLNNNFLRVLPYEIGKLFHLVILGLMGNPL 155

Human   133 TQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVL 197
            .::.:|:|.||:||::||.|:|||||     .|...||.|.|:.|.:|::|||..:|:|||||||
  Fly   156 QKEFMNIYNEPNGTQKLLTYMLDNLS-----FTVNPPPQRPWLPLAKPNKTRPACIFTVMCYNVL 215

Human   198 CDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGF 262
            ||||||||:|||||||||.|:||||:||.||....|||:||||:||||:|.|||.|||..||.|.
  Fly   216 CDKYATRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGI 280

Human   263 FSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIG 327
            |||||||:||||.|||:||||||||:..||||:::..:|||||||||:|||:.||||||.|||||
  Fly   281 FSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIG 345

Human   328 VAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASR 392
            :|.||::::.:.|..|....:   .|.:||..||:|||||:.||||:||||..:|:|.|||:||.
  Fly   346 LAALLKVKENAWEPMSEVTQI---SQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASH 407

Human   393 NLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGT 457
            :.:.....:...:.|:||.|.||||||||||:|..|.|..:|.|||::.|...|.....:..|  
  Fly   408 SFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDMGYKSCLQRLLSNDTN-- 470

Human   458 TNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGC 522
               ..||.|||.|||...:||:||||||||||||||||:|..:..||:|||:.:.||.||.:.||
  Fly   471 ---EFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGC 532

Human   523 PHPLIPSDHFSLFAQLELL 541
            |||.||||||.|..:|||:
  Fly   533 PHPHIPSDHFPLLVELELM 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNOT6NP_001357401.1 leucine-rich repeat 33..52 CDD:275378 10/18 (56%)
LRR <52..>159 CDD:227223 68/106 (64%)
LRR 1 52..73 12/20 (60%)
leucine-rich repeat 53..75 CDD:275378 12/21 (57%)
LRR 2 75..96 16/20 (80%)
leucine-rich repeat 76..98 CDD:275378 16/21 (76%)
LRR 3 98..120 16/21 (76%)
leucine-rich repeat 99..121 CDD:275378 17/21 (81%)
LRR 4 121..143 10/21 (48%)
leucine-rich repeat 122..133 CDD:275378 7/10 (70%)
Nuclease domain. /evidence=ECO:0000250 153..557 224/389 (58%)
Deadenylase_CCR4a 191..540 CDD:197340 206/348 (59%)
twinNP_732964.1 LRR_4 74..114 CDD:289563 24/39 (62%)
LRR_8 75..130 CDD:290566 35/54 (65%)
leucine-rich repeat 76..98 CDD:275378 12/21 (57%)
LRR_4 97..136 CDD:289563 27/38 (71%)
leucine-rich repeat 99..121 CDD:275378 16/21 (76%)
leucine-rich repeat 122..144 CDD:275378 17/21 (81%)
leucine-rich repeat 145..156 CDD:275378 7/10 (70%)
Deadenylase_CCR4 209..550 CDD:197331 206/348 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143750
Domainoid 1 1.000 416 1.000 Domainoid score I660
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 636 1.000 Inparanoid score I830
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57444
OrthoDB 1 1.010 - - D208223at33208
OrthoFinder 1 1.000 - - FOG0002437
OrthoInspector 1 1.000 - - otm40774
orthoMCL 1 0.900 - - OOG6_101771
Panther 1 1.100 - - LDO PTHR12121
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3216
SonicParanoid 1 1.000 - - X1441
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.900

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