Protein Alignment SLC12A5 and slc12a5b

DIOPT Version :10

• Sequence 1: NP_001128243.1
• Gene: SLC12A5 / 57468
• HGNCID: 13818
• Length: 1139
• Species: Homo sapiens
• Sequence 2: XP_009302423.1
• Gene: slc12a5b / 797331
• ZFINID: ZDB-GENE-080707-1
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1118
• Identity: 836/1118 - (74%)
• Similarity: 955/1118 - (85%)
• Gaps: 19/1118 - (1%)

Human    36 GEDVKGDGNPKESSPFINS--TDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGS 98
            |.:.:||...|||||||||  :|.||.::||||||||||||||||||||||||.||||:||.|||
Zfish    14 GPNSQGDATSKESSPFINSSTSDVEKSQQYDGKNMALFEEEMDTSPMVSSLLSSLANYSNLTQGS 78

Human    99 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICC 163
            :|||||||||..:||..|||||||.|||||||||||.|||||||:||:||:.|::.:|.:||:||
Zfish    79 KEHEEAENNEEARKKAAQAPRMGTIMGVYLPCLQNILGVILFLRMTWLVGVGGVLGTFTIVFMCC 143

Human   164 SCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLA 228
            |.|||||||||||||||||||||||||||||||||||||||:||:|||||||||||||.|||||.
Zfish   144 STTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGICFFLGTTFAGAMYILGCIEILLI 208

Human   229 YLFPAMAIFKAEDASG-EA-AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSIL 291
            |:.|:.||||.|...| || ||:|||||||||.|||.||.|||||||||||.|||||.|||||||
Zfish   209 YIVPSAAIFKMEGLEGSEAEAALLNNMRVYGTIVLTFMAIVVFVGVKYVNKLALVFLACVILSIL 273

Human   292 AIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDE 356
            ||||||||::||||:||:|:||||||....:|:|||....||.|:||:||..||.|.||||||||
Zfish   274 AIYAGVIKTSFDPPDFPVCVLGNRTLVSKAYDICAKTIERGNATITTKLWRSFCDSEFLNATCDE 338

Human   357 YFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTS 421
            ||..||:::||||||..||::.|||:|.|:.|..::|:.|:.:|...: .|:...:.||.:|:||
Zfish   339 YFVNNNISQIQGIPGVTSGILAENLFSGYMEKNSVLEKRGLQAVQDPE-LPVTNSNRYVLADITS 402

Human   422 YFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLR 486
            :|||||||||||||||||||||||||:|||||||.||||||.|||.:|:|||:|||||::|||||
Zfish   403 FFTLLVGIYFPSVTGIMAGSNRSGDLQDAQKSIPVGTILAITTTSIIYMSSVILFGACVDGVVLR 467

Human   487 DKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHG 551
            |||||.|:||||:||||||||||||.||||||||||||||||||||||||:||||:|||:|||||
Zfish   468 DKFGEGVSGNLVIGTLAWPSPWVIVFGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLRVFGHG 532

Human   552 KANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRY 616
            ||||||||||||||||||.||||||||.|||||||||||||||||||||:|||||||||||||::
Zfish   533 KANGEPTWALLLTACICESGILIASLDAVAPILSMFFLMCYMFVNLACALQTLLRTPNWRPRFKF 597

Human   617 YHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALL 681
            |||.||.|||||||.|||:||||||:|||:|||.||||||:.||||||||||||:||||||:||:
Zfish   598 YHWALSLLGMSLCLTLMFLCSWYYAIVAMVIAGCIYKYIEFCGAEKEWGDGIRGISLSAARFALM 662

Human   682 RLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQ 746
            |||||||||||||||:|||..:|.:|||..|:||||||||||||||||||:.:|||:|.|.|:.|
Zfish   663 RLEEGPPHTKNWRPQILVLTTLDGEQNVEQPRLLSLTSQLKAGKGLTIVGACIEGTYLNNQPKTQ 727

Human   747 RAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTW 811
            :|::|:|:|||.||||||.||||||||||..|||||:||||||:||||||.:|:||:|.|:|...
Zfish   728 KADQSLRKLMEVEKVKGFSQVVISSNLRDATSHLIQAGGLGGLRHNTVLVSFPKNWKQAEEHHRC 792

Human   812 RNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRK 876
            |||||:||||||||:||||.||:|.:|.|.|||:||.|||||||||||||||||||||.||||||
Zfish   793 RNFIEVVRETTAGHMALLVPKNISAYPSNGERFTEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRK 857

Human   877 CKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQ 941
            ||||||||||||||||||||||.|||||||:.|.||||||.::|||||||||||:|||||||||:
Zfish   858 CKMRIFTVAQMDDNSIQMKKDLMTFLYHLRLDAAVEVVEMLDNDISAYTYEKTLMMEQRSQILKE 922

Human   942 MHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEET-AGDSEEKPEEE---------VQL 996
            |||||||||||||||||.||||||||||:|...:.::.||: ||..|||||||         |||
Zfish   923 MHLTKNEREREIQSITDVSRGSIRRKNPSNLHPQRSIAEESVAGSGEEKPEEESVRVSHPRQVQL 987

Human   997 IHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPE 1061
            |..::|...|:|..|| ..|.....:..|::.:|||.|   .||...|:..:.|.|||.|:||||
Zfish   988 IQGKNATPTPTSPTSP-TAPTPATMSPGEEIQMTWTDD---TEKANNPAVANPENIKDMFNMKPE 1048

Human  1062 WENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVML 1126
            |||||||||||||.|.:|||||||||::|||||||||||||||.|:||||||||||||.|:||:|
Zfish  1049 WENLNQSNVRRMHHAQKLNEVIVKKSQEAKLVLLNMPGPPRNRTGEENYMEFLEVLTEGLNRVLL 1113

Human  1127 VRGGGREVITIYS 1139
            |||||||||||||
Zfish  1114 VRGGGREVITIYS 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		15/28 (54%)
		2a30	44..1139	CDD:273347	831/1108 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..116		16/23 (70%)
		Scissor helix. /evidence=ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:33310850, ECO:0007744|PDB:6M23, ECO:0007744|PDB:7D8Z	667..681		11/13 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	942..1052		58/119 (49%)
slc12a5b	XP_009302423.1	AA_permease_2	24..1126	CDD:459263	831/1106 (75%)