DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC12A5 and NKCC

DIOPT Version :9

Sequence 1:	NP_001128243.1	Gene:	SLC12A5 / 57468	HGNCID:	13818	Length:	1139	Species:	Homo sapiens
Sequence 2:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster

Alignment Length:	1313	Identity:	318/1313 - (24%)
Similarity:	504/1313 - (38%)	Gaps:	419/1313 - (31%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSRRFTVTSLPPA------GPARSPDPESRRHSVADP-------RHL-------PGED------- 38
            |:.||.::.:...      |.|||  .||.:...|.|       .||       .||:
  Fly     1 MADRFQISKVNGTANAGYDGEARS--AESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLS 63

Human    39 VKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANY----TNLPQGSR 99
            .:|.||      |:..:|.|:              :...:.:....|..|.||    .||.:.|.
  Fly    64 FRGFGN------FLRKSDAER--------------KFSLAQLTKESLPRLDNYRISMRNLKRPSI 108

Human   100 EHEEAENNEGGKKKPVQAP-------RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFC 157
            ...:.|..:.....|...|       ::|..:||.:|||.||:||:|||||:|||..:||::|..
  Fly   109 GELQGEAVDQSITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLI 173

Human   158 MVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 222
            ::.|.....::|.:|:|||:|||.|..||.|::||||||||||.:||:.|......:.:|..:|.
  Fly   174 IITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGF 238

Human   223 IEILLAYLFPAMAIFKAEDA----SGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFL 283
            .|.|       ..:.|..|.    :|     :|::|:.|:..:..:..:..||:::..| |..||
  Fly   239 CESL-------NVLLKNNDLKIVDNG-----INDIRIVGSITVLVLILICCVGMEWETK-AQNFL 290

Human   284 GCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSR 348
              ::..:|||:..:|.:|..|                          :|||...:|
  Fly   291 --IVTIVLAIFNFLIGAAIGP--------------------------QGNEEQISR--------- 318

Human   349 FLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHP 413
                               |..|.:...:|||..|.|               ..|:|    ::|
  Fly   319 -------------------GFVGFSWATLKENFGSDY---------------RYAEG----VNH- 344

Human   414 YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGA 478
                |..|.|    .|:|||||||.||:|..|||:||..:||.||..::    .:.:||..||..
  Fly   345 ----DFFSVF----AIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSL----LISMSSYALFVL 397

Human   479 CIEGVVLRDKFG---EAVNGNLV--------VGTLAW-----------PSPW--VIVIGSFFSTC 519
            ...|..:||..|   :.|||.:|        .|...|           .|.|  :|..|.|.:|.
  Fly   398 FAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATL 462

Human   520 GAGLQSLTGAPRLLQAISRDGIVPFLQVFG--HGKANGEPTWALLLTACICEIGILIASLDEVAP 582
            ...|.:|...|||:||:..|.|.|.|..|.  :|| :|||....:||..|....:||..|:.:||
  Fly   463 STALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGK-HGEPYRGYVLTFFITTGFLLIGELNLIAP 526

Human   583 ILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLI 647
            ::|.|:|..|..:|........::...|||.|:||:..||..|.::|:|:||:.::..|::...|
  Fly   527 LISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGI 591

Human   648 AGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHP 712
            ...:|..:.||..|..||...:.....||..|:.||:....|.||:.||:|||    .......|
  Fly   592 IFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVL----SGDPKTRP 652

Human   713 QLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGV 777
            .|:.....|.....|..|.:::  .....:...|...:..::.::|.|:|.|..|:...:|.||:
  Fly   653 PLVDFGYLLTKNNSLMFVANII--PVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDGFSLEDGI 715

Human   778 SHLIQSGGLGGLQHNTVLVGWPRNWR--QKEDHQTW----------------------RNFIELV 818
            :.|.:|.|.|.:..|.||||:..:|.  :||:.:::                      .:|.||.
  Fly   716 NALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELS 780

Human   819 RETT-----AGHL---------------------------------------------------- 826
            .|.|     .||:
  Fly   781 SEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAPMPNM 845

Human   827 ----------------ALLVTKNVSMFPGN--------PERFSEGSIDVWWIVHDGGMLMLLPFL 867
                            ....||..|..|.|        ..:..:|:|||:|:..|||:.:|||::
  Fly   846 QRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYI 910

Human   868 LRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVM 932
            :.....|:..|:|:|.:....|.. |.:|.:.:.|...||                 .|.:.:::
  Fly   911 ISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRI-----------------KYSELIML 957

Human   933 EQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLI 997
            :..|                                                   |:|..:..|.
  Fly   958 KGVS---------------------------------------------------EQPRADTVLK 971

Human   998 HDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEW 1062
            |.:..            ||...|..                         :..||.|     .|.
  Fly   972 HKRLI------------EPFRRGAR-------------------------NEFGITD-----DEL 994

Human  1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLD-RVML 1126
            :::::...|::    |::|::||.|.:|.||::::|.|.:.......||.:||:||..:. .|.|
  Fly   995 QSMSEKTNRQL----RIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVAL 1055

Human  1127 VRGGGREVITIYS 1139
            .||....|:|:||
  Fly  1056 ARGNQTPVLTLYS 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		21/88 (24%)
		2a30	44..1139	CDD:273347	299/1241 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1052		7/109 (6%)
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	295/1205 (24%)
		DUF502	507..>643	CDD:294696	44/135 (33%)
		SLC12	651..1068	CDD:281515	95/533 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2236
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870