DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC12A5 and Ncc69

DIOPT Version :9

Sequence 1:	NP_001128243.1	Gene:	SLC12A5 / 57468	HGNCID:	13818	Length:	1139	Species:	Homo sapiens
Sequence 2:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	1348	Identity:	333/1348 - (24%)
Similarity:	506/1348 - (37%)	Gaps:	468/1348 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    15 PARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEK---GKEYD---GKNMALFEE 73
            |:|..|.::......||::             |.|...|.:..|:   ..|||   ||:...|..
  Fly   105 PSRFKDLQTTTRFQVDPQN-------------EESDESNDSQEERELLDNEYDTKYGKSFRHFTR 156

Human    74 EMDTSPMVSSLLSGLANYTNLPQ------------------GSREHEEAENN--EGGKKKPVQAP 118
            |         .|..|.||.|:..                  |...|....|.  |.|....|.
  Fly   157 E---------ALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVL-- 210

Human   119 RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVP 183
            :.|...||.:.||.||:||:|||||:||||.||::|.|.::....:.|.:||:|||||:||||:.
  Fly   211 KFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIK 275

Human   184 AGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAA 248
            .||:||||||||||||||::||.|.|....|.|||::|..|.:||    .|..|..|...|.
  Fly   276 GGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLA----MMTTFGWEIIDGG--- 333

Human   249 MLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLG 313
             :.::|:.|...:..:..:|.||:::..|   ..:|.:|:.::||...||.|...|
  Fly   334 -VQDVRIIGCITILLLLIIVVVGMEWEAK---AQIGLLIILLVAIGDFVIGSFIGP--------- 385

Human   314 NRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIK 378
                                                          :::....:|..|..:.|.|
  Fly   386 ----------------------------------------------KSDAEMAKGFLGYNATLFK 404

Human   379 ENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNR 443
            .||::.|..     |:.|             :.|     |..|.|    .|:||:.|||:||:|.
  Fly   405 NNLFADYRP-----EKGG-------------IQH-----DFFSVF----AIFFPAATGILAGANI 442

Human   444 SGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFG---EAVNGNL-------- 497
            ||||:|.|||||.||||||..|:..|:..|:..||    .|.||..|   :.|||..
  Fly   443 SGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGNLSDVVNGTFAFLDCQPG 503

Human   498 -----------VVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--G 549
                       |:..::...| :|..|.:.:|..:.|.||..||::.||:.:|.:.|.:..|  |
  Fly   504 ECNYGLQNSFQVIELVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKG 567

Human   550 HGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRF 614
            :|| |.||....:||..|....|||..|:.:||::|.|||..||.:|.:....:|.:...|||.|
  Fly   568 YGK-NNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTF 631

Human   615 RYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYA 679
            :||:..||.||..||:|:||:.||..||:.......:|..:.||..:..||...:..:...|..:
  Fly   632 KYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMS 696

Human   680 LLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEG-------T 737
            :.:|.....|.||:|||:|||..:..    ..|.|:.|...|.....|.:.|.||:|       |
  Fly   697 VQQLNNVEEHVKNYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRT 757

Human   738 FLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNW 802
            :|:     :||....|:    .:||||..:|...:...|...|:|:.|:|.|:.|.:|:|:..:|
  Fly   758 YLQ-----ERAGNWFRK----HRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDW 813

Human   803 RQKEDHQT--------------------------------------WRNFIEL------------ 817
             |..||:.                                      |:...::
  Fly   814 -QTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGD 877

Human   818 -------VRETTAGHL--------------------------------------------ALLVT 831
                   ||...:|.:                                            |...|
  Fly   878 LQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASST 942

Human   832 KNVSMFPGNPERFSEGS------------------------------------------------ 848
            .::|...||..:...|.
  Fly   943 SDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQ 1007

Human   849 ---------IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYH 904
                     |||||:..|||:.:|||:::...:.|:.||:|::.:|..:......::.:.:.|..
  Fly  1008 FTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSK 1072

Human   905 LRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQ--------SITDESR 961
            .||            |.|    :.||:.:          :||..:|...|        .:..|..
  Fly  1073 FRI------------DYS----DLTLIPD----------ITKKPQETSTQFFNELIKDFVVTEKD 1111

Human   962 GSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEK 1026
            |    :|..::|..||              |:..||.|..
  Fly  1112 G----ENGTSSRATLN--------------EDDALITDDD------------------------- 1133

Human  1027 VHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAK 1091
              |...:||:                                     :..:||.|.:.::|..:.
  Fly  1134 --LLAVQDKT-------------------------------------NRYLRLREYLREQSTKSD 1159

Human  1092 LVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
            ||::.:|.|.:|......||.:||.|:..:...:.|||....|:|.||
  Fly  1160 LVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		9/50 (18%)
		2a30	44..1139	CDD:273347	326/1317 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1052		17/117 (15%)
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	10/47 (21%)
		2a30	155..1207	CDD:273347	316/1283 (25%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	59/159 (37%)
		SLC12	724..1207	CDD:281515	101/600 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850