DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC12A5 and kcc

DIOPT Version :9

Sequence 1:NP_001128243.1 Gene:SLC12A5 / 57468 HGNCID:13818 Length:1139 Species:Homo sapiens
Sequence 2:NP_001286795.1 Gene:kcc / 37800 FlyBaseID:FBgn0261794 Length:1077 Species:Drosophila melanogaster


Alignment Length:1119 Identity:575/1119 - (51%)
Similarity:779/1119 - (69%) Gaps:82/1119 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    45 PKESSPFINSTDTEKG----------KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTN-LPQGS 98
            |.|.:..::.|..|..          |.....|:.|::::::|.|.:|:.:|.:|||.| :|..:
  Fly    17 PSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAAT 81

Human    99 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICC 163
                     :...|....:.||||.:||:|||:|||||||||:|||||||.||.:..|.:|..||
  Fly    82 ---------DPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCC 137

Human   164 SCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLA 228
            ..|||||||||||||||||||||||:|||||||||||||||:.||.|||.|.||||:|.:||:|.
  Fly   138 CVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLT 202

Human   229 YLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAI 293
            |:.|..:||  .|.:.:|.||.||.|||||.:|..|..:||:|||:|||||.|.|.||||||:|:
  Fly   203 YMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAV 265

Human   294 YAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYF 358
            |.|:..:........:|:||.|.|.....:.|.|        ..:.|..::|.    :..|:||:
  Fly   266 YVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTK--------EDSFLRDIYCP----DGKCEEYY 318

Human   359 TRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYF 423
            ..||||:::||.|.|||:..:|::.|:|.||..:. .|.:::.:.:.:  ...:..:.:|:|:.|
  Fly   319 LANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFIS-YGKSAIDIENTS--GESYNQIMADITTSF 380

Human   424 TLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDK 488
            |||:||:|||||||||||||||||.|||||||.|||.||.|||.||:|||:.|...::.::||||
  Fly   381 TLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDK 445

Human   489 FGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA 553
            ||:::.|.|||..:|||:.|||:||||.||.|||||||||||||||||:||.|:|||..|.....
  Fly   446 FGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSK 510

Human   554 NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYH 618
            .||||.|||||..||:.|||:.::|.:||:|||||||||.|||||||||||||||||||||::||
  Fly   511 RGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYH 575

Human   619 WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL 683
            |:||.:|::||:::|.:.|||:||:||.:|.:||||||||||||||||||||::|:||||:||||
  Fly   576 WSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRL 640

Human   684 EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRA 748
            |||||||||||||:|||.:::.:....:.::.|..:||||||||||..||::|...:...:|..|
  Fly   641 EEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDA 705

Human   749 EESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRN 813
            :.::|:.|..|||||||.|:::..:.:|:|.:||:.||||::.|||::|||.:||| |...:|:.
  Fly   706 KATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKT 769

Human   814 FIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 878
            ||:.||...|.|:||:|.|.::.:|.:..:.. |:||:||||||||:||||||||:.|:.||.||
  Fly   770 FIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCK 833

Human   879 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMH 943
            :|||||||::||||||||||.||||||||.|:||||||:.|||||||||:||:||||:|:|:.:.
  Fly   834 LRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALG 898

Human   944 LTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHD------QSA 1002
            |.|.|..:.:|:|.|      .::.|::.::.|                 ||.|.|      ::|
  Fly   899 LNKKENSKVVQTIMD------YKETPSDNKMSL-----------------VQTIVDHHYDATKTA 940

Human  1003 PSCPSSSPSPGEEPEGEGETDPEK--VHLTWTKDKSVAE--KNKGPSPVSSEGIKDF-FSMKPEW 1062
            .....:.|:..|....:.:.|.::  :.|...::....|  .||..|...::|  || .|:||: 
  Fly   941 SKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADG--DFKSSVKPD- 1002

Human  1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPR--NRNGDENYMEFLEVLTEHLDRVM 1125
                :.||||||||::||||||:||:||:||::|:|||||  ....:.|||||||||||.|::|:
  Fly  1003 ----EFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVL 1063

Human  1126 LVRGGGREVITIYS 1139
            :|||||||||||||
  Fly  1064 MVRGGGREVITIYS 1077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC12A5NP_001128243.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 5/27 (19%)
2a30 44..1139 CDD:273347 573/1117 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..116 3/24 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 942..1052 21/119 (18%)
kccNP_001286795.1 2a30 49..1077 CDD:273347 568/1085 (52%)
SLC12 674..1077 CDD:281515 205/434 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158239
Domainoid 1 1.000 426 1.000 Domainoid score I605
eggNOG 1 0.900 - - E2759_KOG2082
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1162 1.000 Inparanoid score I205
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 1 1.010 - - D110005at33208
OrthoFinder 1 1.000 - - FOG0000627
OrthoInspector 1 1.000 - - otm41076
orthoMCL 1 0.900 - - OOG6_101034
Panther 1 1.100 - - O PTHR11827
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X451
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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