Protein Alignment SLC12A5 and kcc

DIOPT Version :10

• Sequence 1: NP_001128243.1
• Gene: SLC12A5 / 57468
• HGNCID: 13818
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Alignment Length: 1119
• Identity: 575/1119 - (51%)
• Similarity: 779/1119 - (69%)
• Gaps: 82/1119 - (7%)

Human    45 PKESSPFINSTDTEKG----------KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTN-LPQGS 98
            |.|.:..::.|..|..          |.....|:.|::::::|.|.:|:.:|.:|||.| :|..:
  Fly    17 PSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAAT 81

Human    99 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICC 163
                     :...|....:.||||.:||:|||:|||||||||:|||||||.||.:..|.:|..||
  Fly    82 ---------DPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCC 137

Human   164 SCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLA 228
            ..|||||||||||||||||||||||:|||||||||||||||:.||.|||.|.||||:|.:||:|.
  Fly   138 CVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLT 202

Human   229 YLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAI 293
            |:.|..:||  .|.:.:|.||.||.|||||.:|..|..:||:|||:|||||.|.|.||||||:|:
  Fly   203 YMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAV 265

Human   294 YAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYF 358
            |.|:..:........:|:||.|.|.....:.|.|        ..:.|..::|.    :..|:||:
  Fly   266 YVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTK--------EDSFLRDIYCP----DGKCEEYY 318

Human   359 TRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYF 423
            ..||||:::||.|.|||:..:|::.|:|.||..:. .|.:::.:.:.:  ...:..:.:|:|:.|
  Fly   319 LANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFIS-YGKSAIDIENTS--GESYNQIMADITTSF 380

Human   424 TLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDK 488
            |||:||:|||||||||||||||||.|||||||.|||.||.|||.||:|||:.|...::.::||||
  Fly   381 TLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDK 445

Human   489 FGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA 553
            ||:::.|.|||..:|||:.|||:||||.||.|||||||||||||||||:||.|:|||..|.....
  Fly   446 FGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSK 510

Human   554 NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYH 618
            .||||.|||||..||:.|||:.::|.:||:|||||||||.|||||||||||||||||||||::||
  Fly   511 RGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYH 575

Human   619 WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL 683
            |:||.:|::||:::|.:.|||:||:||.:|.:||||||||||||||||||||::|:||||:||||
  Fly   576 WSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRL 640

Human   684 EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRA 748
            |||||||||||||:|||.:::.:....:.::.|..:||||||||||..||::|...:...:|..|
  Fly   641 EEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDA 705

Human   749 EESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRN 813
            :.::|:.|..|||||||.|:::..:.:|:|.:||:.||||::.|||::|||.:||| |...:|:.
  Fly   706 KATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKT 769

Human   814 FIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 878
            ||:.||...|.|:||:|.|.::.:|.:..:.. |:||:||||||||:||||||||:.|:.||.||
  Fly   770 FIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCK 833

Human   879 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMH 943
            :|||||||::||||||||||.||||||||.|:||||||:.|||||||||:||:||||:|:|:.:.
  Fly   834 LRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALG 898

Human   944 LTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHD------QSA 1002
            |.|.|..:.:|:|.|      .::.|::.::.|                 ||.|.|      ::|
  Fly   899 LNKKENSKVVQTIMD------YKETPSDNKMSL-----------------VQTIVDHHYDATKTA 940

Human  1003 PSCPSSSPSPGEEPEGEGETDPEK--VHLTWTKDKSVAE--KNKGPSPVSSEGIKDF-FSMKPEW 1062
            .....:.|:..|....:.:.|.::  :.|...::....|  .||..|...::|  || .|:||:
  Fly   941 SKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADG--DFKSSVKPD- 1002

Human  1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPR--NRNGDENYMEFLEVLTEHLDRVM 1125
                :.||||||||::||||||:||:||:||::|:|||||  ....:.|||||||||||.|::|:
  Fly  1003 ----EFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVL 1063

Human  1126 LVRGGGREVITIYS 1139
            :|||||||||||||
  Fly  1064 MVRGGGREVITIYS 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		5/27 (19%)
		2a30	44..1139	CDD:273347	573/1117 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..116		3/24 (13%)
		Scissor helix. /evidence=ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:33310850, ECO:0007744|PDB:6M23, ECO:0007744|PDB:7D8Z	667..681		9/13 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	942..1052		21/119 (18%)
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	568/1085 (52%)