DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC12A5 and CG10413

DIOPT Version :9

Sequence 1:	NP_001128243.1	Gene:	SLC12A5 / 57468	HGNCID:	13818	Length:	1139	Species:	Homo sapiens
Sequence 2:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	1186	Identity:	284/1186 - (23%)
Similarity:	462/1186 - (38%)	Gaps:	346/1186 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    46 KESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENN--- 107
            :|::|..||.        .|:..::|..       ..||..|..|     .|.|.|...:.:
  Fly     7 QETAPIANSR--------SGRTGSVFRS-------FGSLFGGSQN-----SGDRPHTPQDGDGYV 51

Human   108 EGGKKKPVQAPR-MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAI 171
            |.|.:.|.::.| :|||.||:.|...::|..::|:|:.::||.||:..:.....|.....:.|..
  Fly    52 EFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVA 116

Human   172 SMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAI 236
            |:.||:|||.:..||.|:||||:||.||||::|..|:.......||.|.|..|.::....|
  Fly   117 SVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGP---- 177

Human   237 FKAEDASGEA------------AAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 289
             :....||::            ::|:|.::     :|.|:     ||.....|.:::.|.
  Fly   178 -RGHFVSGDSHLPDGDWWRFLTSSMINTLQ-----LLVCL-----VGAALFAKTSVIILA----- 226

Human   290 ILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATC 354
                                                         |||..|:..:.|..|:.||
  Fly   227 ---------------------------------------------TVTVCLFATYFSFLFVGAT- 245

Human   355 DEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDM 419
                  ||...:.|          :|:.|:..|   .::.:|:.:..|.|.........|..:..
  Fly   246 ------NNTIPVPG----------DNILSNTTT---FLDYTGLNATTLRDNLGSHYGRDYTSNGK 291

Human   420 TSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVV 484
            ...|:...|:.|..|||||||:|.||:|::..||||.||:.|:|.|...||....|.........
  Fly   292 QVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFT 356

Human   485 LRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFG 549
            :::.:...:..||      || |:. .||...:|....|.:|.|:.|:|:|:|:|      ||||
  Fly   357 MQNNYLFLMPVNL------WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFG 407

Human   550 -------HGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRT 607
                   ||...|.|..|:.::.|:.|..:||.|.:.:|.|.|:.|::.|:..||||....|...
  Fly   408 SLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGA 472

Human   608 PNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYA---LVAMLIAGLIYKYIEYRGAEKEWGDGIR 669
            ||:||.|:::.|....:|:...|.:||:.::.||   ::..||..:............:||...:
  Fly   473 PNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQ 537

Human   670 GLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQ----LLSLTSQLKAGKGLTIV 730
            .|.....|..||.|:....|.|.||||:|:||.        .|:    |:...:.||. .||.|:
  Fly   538 ALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVS--------SPRSCCPLVDFVNDLKK-SGLYII 593

Human   731 GSVLEGTF--LENHPQAQRAEESIR--RLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQH 791
            |.|..|.|  :|:      ||::.:  ..::..:||.|.:|.:|.::|:||.|||:..|:|.::.
  Fly   594 GHVKLGDFKGIED------AEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKP 652

Human   792 NTVLVGW-----PRNW-----------------------RQKEDHQTW--RNFIELVRETTAGHL 826
            ||:::|:     ||::                       |:..|.:.:  :.:::::.:|.....
  Fly   653 NTIILGFYDSEAPRDFFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKK 717

Human   827 ALLVTKNVSMFPGNPERFSE--GSIDVWWI---------VHDGGMLMLLPFLLRHHKVWRKCKMR 880
            .|.:.:|......|....|:  ..||||.|         ..|...|.::...:.....|:..::|
  Fly   718 NLCLCRNFQRLDKNFISMSKHVKYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVR 782

Human   881 IF--------TVAQMDDNSIQM----KKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVME 933
            ||        ||...|..:.||    |..|...|..|||||  ::||:.|       :.:.....
  Fly   783 IFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITA--DIVEIQE-------WSRDTDFS 838

Human   934 QRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 998
            :.::.|||.                             |....||..|   |.:|..|
  Fly   839 RHARTLKQF-----------------------------TAQADNVVLE---DDDEVGE------- 864

Human   999 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWE 1063
                                                                            |
  Fly   865 ----------------------------------------------------------------E 865

Human  1064 NLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGD-----ENYMEFLEVLTEHLDR 1123
            .||:|.:...    |.|::|.::|....|..:.:..||:....|     .:|||.|..||..|..
  Fly   866 TLNRSLLYMQ----RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPP 926

Human  1124 VMLVRGGGREVITIYS 1139
            .:||.|    |.|:.|
  Fly   927 TILVHG----VSTVTS 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		4/16 (25%)
		2a30	44..1139	CDD:273347	283/1184 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1052		7/109 (6%)
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	275/1151 (24%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	96/477 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840