DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC12A5 and CG12773

DIOPT Version :9

Sequence 1:	NP_001128243.1	Gene:	SLC12A5 / 57468	HGNCID:	13818	Length:	1139	Species:	Homo sapiens
Sequence 2:	NP_001284773.1	Gene:	CG12773 / 31082	FlyBaseID:	FBgn0024365	Length:	712	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	167/757 - (22%)
Similarity:	285/757 - (37%)	Gaps:	273/757 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    40 KGDGNPKESSPFINSTDTEK---GKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101
            :|:||...     .:.|.::   |.:.|| ::|:......|:......:.....||....|   |
  Fly     6 EGNGNGGR-----RTVDWQRFGLGGDEDG-DVAVTSFRQRTNNNTGGFVDLGNEYTYAAGG---H 61

Human   102 EEAENNE--GGKK--KP-------VQAPRM-GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIME 154
            ..:..||  .|::  ||       :..|.: ||:.||:..||.|:||||:|||..|:|..|||:.
  Fly    62 HASGANEIFAGEQGDKPWWRSNFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILN 126

Human   155 SFCMVFICCSCTMLTAISMSAIATNGV-----VPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFA 214
            :..::|    ||::.|: :|.::..|:     |.:||.|::|:.:||..||||:||.:..|....
  Fly   127 AVLIIF----CTVVIAL-VSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVG 186

Human   215 GAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFA 279
            .|:.::|..|        :||.....:.|..|      :|.:.|..:..:..:...|||:|.|
  Fly   187 CALNVMGFGE--------SMAGLVGLEGSKWA------IRGFATAAVLLLGCINVAGVKWVIK-- 235

Human   280 LVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLF 344
               |..::|.||.|      ||.|      .::|:.|....|
  Fly   236 ---LQFILLMILLI------SALD------FMVGSFTSEASG----------------------- 262

Human   345 CSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPID 409
                                   |..|.|||...||||..|
  Fly   263 -----------------------GFNGWASGNFVENLWPKY------------------------ 280

Human   410 MDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVV 474
                   .|..|:|.:. |::||:|||:::|.|.|||||.....||.||:.|..|::.:|:..|:
  Fly   281 -------DDGYSWFRVF-GVFFPTVTGVLSGINMSGDLRAPSTDIPNGTLAAFGTSTFLYLVFVL 337

Human   475 LFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRD 539
            ..||..:...|...:..:|..:.|        .::::.|.:.|:..:.|.::.|.||:||:|:::
  Fly   338 FLGATCQRSFLYTDYMISVKVSAV--------HFLLLAGIYVSSMSSCLGAMYGTPRVLQSIAKE 394

Human   540 GIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLA--CAV 601
            .::|.:.:.|.|:. |..|.:|:.:.|.:....|::..::.:|||::|.||:.|..::.|  ...
  Fly   395 SVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYACIDYAYFALA 459

Human   602 QTL-------------LRTPNWRPRFRY------------------------------YHWTL-- 621
            ||.             ..:|::..| ||                              .|.|:
  Fly   460 QTFDIQEQREERFRIQASSPSYETR-RYGSVSDTGNDLDLLFPDRVRHKNLQSPQNSPLHQTVPL 523

Human   622 ----------------------------------------------------------------- 621

  Fly   524 EFDNEGPSTSNQAQSSERRTGHEADTTLAVEQAVAQAGVEQDQGDEAEPIAPIRPPIHSKTKNWY 588

Human   622 --------SFLGMSLCLALMFICSWYYALVAMLIAGLIYKYI 655
                    |.||....|.:|.:.:|||||...|:..:::.|:
  Fly   589 SGYCNRWASLLGAFTKLLVMLLVNWYYALTCFLVVFVVWFYV 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		5/25 (20%)
		2a30	44..1139	CDD:273347	165/753 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1052
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	129/489 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910