Protein Alignment SLC12A5 and kcc-2

DIOPT Version :10

• Sequence 1: NP_001128243.1
• Gene: SLC12A5 / 57468
• HGNCID: 13818
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_001255279.2
• Gene: kcc-2 / 177370
• WormBaseID: WBGene00019205
• Length: 1129
• Species: Caenorhabditis elegans
• Alignment Length: 1150
• Identity: 502/1150 - (43%)
• Similarity: 719/1150 - (62%)
• Gaps: 101/1150 - (8%)

Human    19 PDP-ESRRHSVADPRHLPGEDVKGDGNPKESSPFIN-STDTEKGKE-----YDGKNMALFEEEMD 76
            |:| .|...:....|...|....|.|...:..|.:: :..|::|.|     .....:||:|::.|
 Worm    52 PEPTSSTSTNTVTSRRSSGGSGSGLGPASKKPPNMHINIPTDEGAERIPLCEQHSPLALYEQDYD 116

Human    77 T-SPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILF 140
            | ...:.::|..|:.|        ...||.:.|..:|....|.:|||.|||:||||||||||:.|
 Worm   117 TQGQKIGTMLRKLSVY--------NATEATSVEADEKPKAAAAKMGTIMGVFLPCLQNIFGVLFF 173

Human   141 LRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGL 205
            :||.|::|.||:.::|.:|..|.|.|.||:||:||||||||||:||.||||||:||||.|||||:
 Worm   174 IRLAWIIGTAGVFQAFFVVLTCVSVTFLTSISLSAIATNGVVPSGGPYYMISRNLGPELGGAVGI 238

Human   206 CFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFV 270
            .||||||.|.:|||.|.|||||.|::|...:|  :|       :.:|.||.||.:|..:..:|..
 Worm   239 LFYLGTTIAASMYITGAIEILLLYIYPQAKLF--DD-------IYHNFRVLGTVLLLILGLIVMA 294

Human   271 GVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNET 335
            |||:||:.||..:..|||.||:...||........:...|::|:|.:....:  ..|...:.|.|
 Worm   295 GVKFVNRCALPLVIVVILCILSAILGVFVRYDGSDSLKFCMVGDRPVDLSTY--FEKTQVQPNCT 357

Human   336 VTTRLWGLFCSSRFLNATCDEYFTRNN------------VTEIQGIPGAASGLIKENLWSSYLTK 388
             ...|..||||:   |.|||.|:.|..            :.|.:.|.|.|||:..:|||..||..
 Worm   358 -ADGLQDLFCST---NGTCDHYYDRMKNIKVWKSSGMPAIREERAIKGIASGVFFDNLWPKYLRA 418

Human   389 GVIVERSGMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQK 452
            |.::.:.......|..|     .|| |::::..:.|.:|||::|||.|||||||||||:||||.|
 Worm   419 GEVLSKDRKDKGDLNRG-----GHPSYIYAESVTNFMILVGVFFPSATGIMAGSNRSGNLRDAAK 478

Human   453 SIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFS 517
            |||.||:.|...:|.:|:..||||||.:..:.:|||:|.:..|.|::..::||.|.||:.|.|.|
 Worm   479 SIPLGTLAAQNFSSFIYLLGVVLFGASVSEMFIRDKYGRSAMGKLIISEISWPFPQVILFGCFMS 543

Human   518 TCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAP 582
            |.|||:|||||||||||||:.|.::|||:.|....:.|||..|:|||..|||.|||||.::.:..
 Worm   544 TAGAGMQSLTGAPRLLQAIAADDVLPFLKPFRKMDSRGEPIRAILLTLAICECGILIAVIENITA 608

Human   583 ILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLI 647
            :::.||||||:.||.|||:|:||::|.|||.|||:||:||.:|..||:|:|||.:|::||.|::|
 Worm   609 LITQFFLMCYLGVNAACALQSLLKSPGWRPGFRYFHWSLSMIGAILCVAVMFISAWHFALFAIII 673

Human   648 AGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHP 712
            ...:||||||.|||||||||:|||.|||||:|||.|::.|.|::|||||||||....:..|.  .
 Worm   674 GAGVYKYIEYAGAEKEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLLVLAPDVESANT--N 736

Human   713 QLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGV 777
            .:||..||||||||||:|...:||.:.:|:.:||..:|.::.:::..|:||||.|:::||:.:|:
 Worm   737 GILSFVSQLKAGKGLTLVAHCMEGEYADNYLKAQAVQEKLKAVVKKNKIKGFCDVLVTSNVIEGI 801

Human   778 SHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPE 842
            |.|:|:.||||::||||::.||.:|:.:::......|:..:|..:|...|::|.|....||.|..
 Worm   802 SCLVQTSGLGGMRHNTVVLSWPNDWKAEQEWVVANKFVSAIRAISAAKCAIMVPKYAEKFPANGT 866

Human   843 RFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRI 907
            :.| |.|||||:|||||:|||||||||.||.|:...:|:|.:|||:||::|||.||..|||||||
 Worm   867 KVS-GFIDVWWVVHDGGLLMLLPFLLRQHKTWKNTTVRLFAIAQMEDNNVQMKTDLEKFLYHLRI 930

Human   908 TAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQS----ITDESRGS-IRRK 967
            .|.|.|:||.:||||.||||:|:.||:|:|.||  :|.|::|:::||:    :|.|.:.| |..:
 Worm   931 DAAVNVIEMTDSDISDYTYERTMKMEERNQYLK--NLNKSDRDKDIQNHLEIVTRERKLSRINEE 993

Human   968 NPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVH---L 1029
            .||      .|||          :..::::.:              |:.:|:.|....|:.   :
 Worm   994 APA------VVPE----------QRNLEVVDE--------------EQEDGKSENGSAKIEHKGV 1028

Human  1030 TWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVL 1094
            .::.|:...|...|...:..:        :.|.:...:.||.:|||||:|||::.:||.||:||.
 Worm  1029 RFSDDEDSKEVKVGNGTLERD--------REERQRKRRYNVHKMHTAVKLNELMRQKSSDAQLVF 1085

Human  1095 LNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
            :|:|||| :.:.|..||:|:|.|||.||||:||||.|.||:||||
 Worm  1086 VNLPGPP-DADSDSYYMDFIEALTEGLDRVLLVRGTGAEVVTIYS 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		11/50 (22%)
		2a30	44..1139	CDD:273347	493/1122 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..116		4/23 (17%)
		Scissor helix. /evidence=ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:33310850, ECO:0007744|PDB:6M23, ECO:0007744|PDB:7D8Z	667..681		10/13 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	942..1052		21/117 (18%)
kcc-2	NP_001255279.2	AA_permease_2	144..1129	CDD:459263	478/1048 (46%)