Protein Alignment SCAF4 and NRD1

DIOPT Version :10

• Sequence 1: NP_065757.1
• Gene: SCAF4 / 57466
• HGNCID: 19304
• Length: 1147
• Species: Homo sapiens
• Sequence 2: NP_014148.1
• Gene: NRD1 / 855470
• SGDID: S000005195
• Length: 575
• Species: Saccharomyces cerevisiae
• Alignment Length: 791
• Identity: 147/791 - (18%)
• Similarity: 248/791 - (31%)
• Gaps: 302/791 - (38%)

Human     2 DAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYVI 66
            |....|...|.|..|:|..||.:::..:|..|:..|.:...::.::..:.:.|...:|:..||:|
Yeast     5 DDFQNFVATLESFKDLKSGISGSRIKKLTTYALDHIDIESKIISLIIDYSRLCPDSHKLGSLYII 69

Human    67 DSIVR----QSR--------------HQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRV 113
            |||.|    ::|              |...|..:|.....|..|..:.|       :.|.||..:
Yeast    70 DSIGRAYLDETRSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQ-------DHKEKIRML 127

Human   114 LNLWQKNGVFKIEIIQPL------LDMAAGTSNAA-------PVAEN---VTNNEGSPPPPVKVS 162
            |::|.::|:|:...:..:      :|::..|:|.|       |...:   ::|.:.|||..:.:|
Yeast   128 LDIWDRSGLFQKSYLNAIRSKCFAMDISNNTANTASQQLSLDPKQRSKQILSNLKKSPPLNLNIS 192

Human   163 SEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQV 227
            .  ||..|           |:|.....|.|||.                               :
Yeast   193 L--PTDLT-----------STDPAKQQAALFQV-------------------------------I 213

Human   228 QAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAA 292
            .|:....||.|:..|....|  ||:..|.        .:|....|...|.::.:
Yeast   214 AALQKHFKTLPSHTSVGTVA--PPQAHTI--------TEYGSRRERERERERYN----------- 257

Human   293 AVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQV 357
                        :....:.|||   |||..|..|.:.              |...:.||  .:.:
Yeast   258 ------------SRRNRSRSPP---APFSQPSTGRKD--------------RYPSVAQD--QYSI 291

Human   358 PLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQ 422
            ..|                                  ..:|...|..|    :..|:.|
Yeast   292 GAP----------------------------------NTTFGTNNHHL----YPDELNV------ 312

Human   423 EVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKE 487
                             |.:|               |.|.:..|.|
Yeast   313 -----------------SNNP---------------HYRPKPVSYD------------------- 326

Human   488 RERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVH 552
                 ..||   |:...|.|.||::|.:.....:.|:|::|:.|..::|:.:...|..|::.:..
Yeast   327 -----STLP---PDHIKVYSRTLFIGGVPLNMKEWDLANVLKPFAEVQSVILNNSRKHAFVKVYS 383

Human   553 RQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIK--ADYKQYWDVELGVTYIPWDKVKPEELESF 615
            |.:|...||..:    |.....::..|.:..|.:  .||:.      |.:.||..:
Yeast   384 RHEAENVLQNFN----KDGALPLRTRWGVGFGPRDCCDYQH------GYSIIPMHR--------- 429

Human   616 CEGGMLDSD---TLNPDWKGIPKKP-------------------ENEVAQNGGAETSHTEPVSPI 658
                :.|:|   :::..|.|...:|                   ...::|....::....|.|..
Yeast   430 ----LTDADKKWSVSAQWGGTSGQPLVTGIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGK 490

Human   659 PKPLPVPVPPIPVP---APITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720
            |..........|||   ||:..||||    |...|::  .||..:.|  ..|.|..||....||.
Yeast   491 PNKSGSISSISPVPYGNAPLASPPPQ----QYVQPMM--QQPYGYAP--NQPLPSQGPAAAAPPV 547

Human   721 PPPFLRPGFNP 731
            |    :..|:|
Yeast   548 P----QQQFDP 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAF4	NP_065757.1	CID_SFRS15_SCAF4	5..135	CDD:340802	34/153 (22%)
		PRK12323	<133..281	CDD:481241	31/157 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..179		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..254		7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..331		10/61 (16%)
		PAT1	<328..>412	CDD:401645	7/83 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..502		9/77 (12%)
		RRM_SCAF4	504..584	CDD:409894	18/79 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..661		7/50 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	879..1147
		PRK12678	<984..>1053	CDD:237171
NRD1	NP_014148.1	CID_Nrd1_like	8..149	CDD:340781	33/147 (22%)
		RRM_NRD1_SEB1_like	336..412	CDD:409768	18/79 (23%)