Protein Alignment TBC1D24 and mtd

DIOPT Version :10

• Sequence 1: NP_001186036.1
• Gene: TBC1D24 / 57465
• HGNCID: 29203
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_001246928.1
• Gene: mtd / 45467
• FlyBaseID: FBgn0013576
• Length: 1344
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 109/533 - (20%)
• Similarity: 196/533 - (36%)
• Gaps: 160/533 - (30%)

Human    63 PCRTVTPDASVYSD--------IVGKIVGKHSSSCLPLPEFVDNTQVPSYCLNARGEGAVRKILL 119
            |...:||. |.:|:        .:|..:..|||                       ||......|
  Fly   929 PVPPLTPH-STHSEGHMTYGRSSIGTFIRPHSS-----------------------EGTSSSTKL 969

Human   120 CLANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRIL-----ACNDP--------GRRLIDQ 171
            ..|.|.|.:.:    .::|::     .|:.|.|....:::     ||.||        |:.:  .
  Fly   970 KEAKQAPKLDY----RSMVSM-----DDKPELFISVDKLIPRPARACLDPPLYLRLRMGKPI--G 1023

Human   172 SFLAFESSCMTFG--DLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFGELPLCYFARVFDVFLV 234
            ..:...:|.|::|  .|..:|..:..|..|   :::.:....|.:.|:|||.       .:....
  Fly  1024 KAIPLPTSVMSYGKNKLRAEYWFSVPKNRV---DELYRFINTWVKHLYGELD-------EEQIKA 1078

Human   235 EGYKVLYRVALAILKFFHKVRAGQPLESDSVKQDIRTFVRDIAKTVSPEKLLEKAFAIRLFSRKE 299
            .|::::............|...|...:......|:         |....:|::..||      |.
  Fly  1079 RGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDL---------TRESWELIKAPFA------KT 1128

Human   300 IQLLQMANEKA---LKQKGITVKQKSVSLSKRQFVHLAVHAENF------------RSEIVSVRE 349
            .::::.|:..|   |:..|..|    :|:|..::...::.|...            ::||::...
  Fly  1129 YKIIKTASHAASHDLEMLGGEV----LSMSTDEYRKTSLFATGSFDLDFPIPDLIGKTEILTEEH 1189

Human   350 MRDIWSWVPERFALCQPLLLFSSLQHGYSLARFYFQCEGHE-PTLLLIKTTQKEVCGAYLSTDWS 413
            ...:.|.:|.|.......|:||:.|||::|...|.:....| |.|::|:.|:..|.||..|....
  Fly  1190 REKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSCSLH 1254

Human   414 ERNKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKPPPLMAAEPTAPLSHSASSDPADR 478
            ..:.      |:||||..:::..|..:.:.|.
  Fly  1255 VSDH------FYGTGESLLYKFNPSFKVFHWT--------------------------------- 1280

Human   479 LSPFLAARHFNLPSKTESM-FMAGGSDCLIVGGGGGQ-ALYIDGDLNRGRTSHCDTFNNQPLC-S 540
                           .|:| |:.|..:.|.:|.|.|: .|::|||||:||:..|.|:.|:||. .
  Fly  1281 ---------------GENMYFIKGNMESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQ 1330

Human   541 ENFLIAAVEAWGF 553
            |:|:|..:|.|.|
  Fly  1331 EDFVIKTLECWAF 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D24	NP_001186036.1	RabGAP-TBC	48..253	CDD:459855	37/212 (17%)
		TLDc	342..554	CDD:214733	56/216 (26%)
mtd	NP_001246928.1	LysM	<250..371	CDD:440998
		TLDc	1182..1344	CDD:214733	56/216 (26%)