Protein Alignment TBC1D24 and sky

DIOPT Version :10

• Sequence 1: NP_001186036.1
• Gene: TBC1D24 / 57465
• HGNCID: 29203
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_001260649.1
• Gene: sky / 35359
• FlyBaseID: FBgn0032901
• Length: 607
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 177/593 - (29%)
• Similarity: 269/593 - (45%)
• Gaps: 105/593 - (17%)

Human    24 PKELSCTELQEL---------KQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVG 79
            |...|.||:|:|         |.:.|:..|..:..:|.:::..|......:....| ..|.::|.
  Fly    54 PALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLD-GFYWEMVH 117

Human    80 KIVGKHSSSCLP--LPEFVDNTQVPSYCLNARGEGAVRKILLCLANQFPDISFCPALPAVVALLL 142
            ::.|....|..|  ||.|||.|....|.|.:.|.....:|:..|....|||::.|.|..:.::||
  Fly   118 QVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILL 182

Human   143 HYSIDEAECFEKACRILACNDPGRRLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVL- 206
            |: :.|.|.:  .|.........:..|:|:.|..|.:..|...:..|:.::|......:...:.
  Fly   183 HF-MSEEEAY--ICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKL 244

Human   207 -QVYADWQRWLFGELPLCYFARVFDVFLVEGYKVLYRVALAILKFFHK-VRAGQPLESDSVKQDI 269
             :::.||..|:...||..:..|:.|.:..||.||||||||.||..||| .::......|::|.||
  Fly   245 ERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDI 309

Human   270 RTFVRDIAK--TVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALK-------------------- 312
            ...:....|  .|||.|||..||:||..|.:.|..:.:..|..||
  Fly   310 GNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDN 374

Human   313 ----QKGITVKQKSVSLSKRQFVH------------------LAVH-AENFRSEIVSVREMRDIW 354
                |..:.::..|.:|:.|:.:|                  :.|: ..|.:|:.....::..:|
  Fly   375 LPTSQSQVNIQMMSHTLTIREKLHSESCRNLGEKSPGHRAIAMGVYPIHNLKSQACKNEDLFTLW 439

Human   355 SWVPERFALCQPLLLFSSLQHGYSLARFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERN--- 416
            ||:|.|..:.||:||:::.:||.||..||.:.|.||||||:|||...||.|||.|:.|.|||
  Fly   440 SWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKD 504

Human   417 KFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKPPPLMAAEPTAPLSHSASSDPADRLSP 481
            ..|.:..:|||||.|:|.|.||..:|.||.|              |....|.||:
  Fly   505 DKGQRQAYFGTGETFLFSLYPERAKYPWVGI--------------EGDKDLGHSS---------- 545

Human   482 FLAARHFNLPSKTESMFMAGGSDCLIVGGGGGQALYIDGDLNRGRTSHCDTFNNQPLC-SENFLI 545
                          .:|||..|..:.:|||.|||:::|.::..|:|..|.||||.||| |.:|.|
  Fly   546 --------------ELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEI 596

Human   546 AAVEAWGF 553
            ..:|.:||
  Fly   597 RVLEVYGF 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D24	NP_001186036.1	RabGAP-TBC	48..253	CDD:459855	57/208 (27%)
		TLDc	342..554	CDD:214733	82/216 (38%)
sky	NP_001260649.1	TBC	82..293	CDD:214540	59/214 (28%)
		TLDc	431..605	CDD:214733	81/212 (38%)