Protein Alignment MYORG and ROT2

DIOPT Version :10

• Sequence 1: NP_065753.2
• Gene: MYORG / 57462
• HGNCID: 19918
• Length: 714
• Species: Homo sapiens
• Sequence 2: NP_009788.3
• Gene: ROT2 / 852530
• SGDID: S000000433
• Length: 954
• Species: Saccharomyces cerevisiae
• Alignment Length: 610
• Identity: 126/610 - (20%)
• Similarity: 217/610 - (35%)
• Gaps: 148/610 - (24%)

Human   177 FLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVY-----SSDAAFGGILERYWLSSRAAA 236
            |:|  :.:.||..|..|....:...|.:||......||:     :|...:|
Yeast   265 FMG--STNVYGIPEHATSLRLMDTSGGKEPYRLFNVDVFEYNIGTSQPMYG-------------- 313

Human   237 IKVNDSVPFHLGWNSTERS-LRLQARYHDTPYKPPAGRAAAPELSYR------VCVGSDVTSIHK 294
                 |:||....:||... :.....:.|..|.....:.....:|..      :.:|.|:.:|
Yeast   314 -----SIPFMFSSSSTSIFWVNAADTWVDIKYDTSKNKTMTHWISENGVIDVVMSLGPDIPTI-- 371

Human   295 YMVRRYFNKPSRVPAPEAFRDPIWS------TWALYGRAVDQDKVLRFAQQIRLHHFNSSHLEID 353
              :.::.:...|     .|..||.|      .|. |.   |:..||....|:..|......:.:|
Yeast   372 --IDKFTDLTGR-----PFLPPISSIGYHQCRWN-YN---DEMDVLTVDSQMDAHMIPYDFIWLD 425

Human   354 DMYTPAYGDFDFDEVKFPNASDMFRRLRDAGFRVTLWVHP-----------FVNYN--------- 398
            ..||.....|.:.:..|||...:..:|:..|..:.:.:.|           .:|.|
Yeast   426 LEYTNDKKYFTWKQHSFPNPKRLLSKLKKLGRNLVVLIDPHLKKDYEISDRVINENVAVKDHNGN 490

Human   399 ----------------SSRFGEGVERELFVREPTGRLPALVR---WWNGIGAVLDFTHPKA---R 441
                            .|::|:.:.:..|.|...  |||.:.   .||.:.....|..|:.   :
Yeast   491 DYVGHCWPGNSIWIDTISKYGQKIWKSFFERFMD--LPADLTNLFIWNDMNEPSIFDGPETTAPK 553

Human   442 DWFQGHLRRLRSRY-----SVASFKFDAGEVSYLPRDFSTYRPLPDPSVWSRRYTEMALPFFSLA 501
            |....:....||.:     ||....:||.:..|.|.|       ..|.:.:|.:      |....
Yeast   554 DLIHDNYIEERSVHNIYGLSVHEATYDAIKSIYSPSD-------KRPFLLTRAF------FAGSQ 605

Human   502 EVRVGYQSQNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMVGGNAVPQRTAGG 566
            .....:...|:          :.|.|   |:..||.||:.::.|.|||..|:.|         ..
Yeast   606 RTAATWTGDNV----------ANWDY---LKISIPMVLSNNIAGMPFIGADIAG---------FA 648

Human   567 DVPERELYIRWLEVAAFMPAMQFSI-------PPWRYDAEVVAIAQKFAALRASLVAPLLLELAG 624
            :.|..||..||.:...:.|..:...       .|:.::..:.:|.:....||..|: |.|..:..
Yeast   649 EDPTPELIARWYQAGLWYPFFRAHAHIDTKRREPYLFNEPLKSIVRDIIQLRYFLL-PTLYTMFH 712

Human   625 EVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDT-LLVAPVLEPGKQERDVYLPAG---KWRSY 685
            :.:.||.||:.|::...|.....:.||:||...:: |||.||.|||:.|.::..|.|   ::.|.
Yeast   713 KSSVTGFPIMNPMFIEHPEFAELYHIDNQFYWSNSGLLVKPVTEPGQSETEMVFPPGIFYEFASL 777

Human   686 KGELFDKTPVLLTDYPVDLDEIAYF 710
            ...:.:.|.::..:....||:|..|
Yeast   778 HSFINNGTDLIEKNISAPLDKIPLF 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYORG	NP_065753.2	GH31_NET37	314..682	CDD:269878	94/431 (22%)
ROT2	NP_009788.3	GH31_N	259..380	CDD:270212	24/139 (17%)
		GH31_GANC_GANAB_alpha	380..850	CDD:269889	102/470 (22%)