Protein Alignment MYORG and aagr-2

DIOPT Version :10

• Sequence 1: NP_065753.2
• Gene: MYORG / 57462
• HGNCID: 19918
• Length: 714
• Species: Homo sapiens
• Sequence 2: NP_494897.3
• Gene: aagr-2 / 173848
• WormBaseID: WBGene00019895
• Length: 955
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 129/650 - (19%)
• Similarity: 216/650 - (33%)
• Gaps: 236/650 - (36%)

Human   167 APGRAVEHAMFLGDAAAHWYGG--AEMRTQHWPIRLDGQQEPQPFVTSDVYSSDAAFGGILERYW 229
            |||.::.:....|:...:::.|  .||.||.: ::..|    :||:.:  |   .|.|..|.||.
 Worm   251 APGPSLIYRTIGGNLDMYFFPGPTPEMVTQQY-LKFIG----KPFLPA--Y---WALGYQLSRYG 305

Human   230 ------LSSRAAAIKVNDSVPFHLGWNSTERSLRLQARYHDTPYKPPAGRAAAPELSYRVCVGSD 288
                  :.:|..|:: :..:|..:|    ...:....||.|                  ...|.|
 Worm   306 YKGLAEMKTRIQAVR-DAGIPIDIG----VADIDYMQRYKD------------------FTTGDD 347

Human   289 -------VTSIHKYMVRRYFNKPSRVPAPEAFRDPIWSTWALYGRAVDQD-KVLRFAQQIRLHHF 345
                   |.::|.:.::...          .|...|.:|:..:.||:..: |.:.:..:.::
 Worm   348 WAGFSDYVKTMHDWGMKLIL----------IFDPAIEATYPSFQRAIAANAKFIEWETKAQV--- 399

Human   346 NSSHLEIDDMYTPAYGD--------FDFDEVKFPNASDMFRRLRDAGFRVTLWVHPFVNYNSSRF 402
               ...|.::| |...|        :..:.|.||:..|.....::      .|::.||||.|...
 Worm   400 ---QTAIQNLY-PMAKDTKIMLGVVWPDNHVAFPDFLDSTNNTQN------WWINEFVNYQSQVA 454

Human   403 GEGVERELFVREPTGRLPALVRWWNGIGAVLDFTHPKARDWFQGHLRRLRSRYSVASFKFDAGEV 467
            .:|:..::  .||           :..|...|  ||    |:                 ||:.:
 Worm   455 FDGIWIDM--NEP-----------SNFGTNQD--HP----WY-----------------FDSDD- 482

Human   468 SYLPRDFSTYRPLPDPSVWSRRYTEMALPFFSLAEVRVG------YQSQNISCFFRLVD------ 520
              .|.|...:.|....|.|     ||. |:.:.|..|.|      :.|.|..|.....|
 Worm   483 --HPNDAPLFCPTNGSSPW-----EMP-PYKTRAVWRFGDANSGAFLSSNTLCMLAQQDGGKQRF 539

Human   521 -------------------------RDSV------------WGYDLG--------LRSLIPAVLT 540
                                     |.:|            .|:.||        ||:.:.....
 Worm   540 YNVKNLYGLTEAINTQKALFKATGKRGAVVSRSTYPSAGRYAGHWLGDNTARWEDLRTSVIGAQE 604

Human   541 VSMLGYPFILPDMVG--GNAVPQRTAGGDVPERELYIRWLEVAAF-----------MPAMQFSIP 592
            .::.|.|::..|:.|  |...           .||.:||.::.||           .||...::.
 Worm   605 FNLFGIPYVGSDVCGFIGTTT-----------EELCLRWQQMGAFHSFFRNHNTIGAPAQDPAVW 658

Human   593 PWRYDAEVVAIAQKFAALRASLVAPLLLELAGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIG 657
            |      .||.|.|.|.|......|.|..|....:.:|..::||:::..|.|.....:..:|:.|
 Worm   659 P------SVAAATKKANLFRYQYLPYLFSLHFTASLSGATVIRPVFFEYPTDAETFNLGYEFMWG 717

Human   658 DTLLVAPVLEPGKQERDVYLPAGKWRSYKGELFD--------------------KTPVLLTDYPV 702
            ..:|||||:..|....:.|||..:|.|    |||                    :.||.:..|.|
 Worm   718 SRILVAPVIYQGTTSVNAYLPTDRWYS----LFDYRYGSIMSPGYATVPAPTTSRIPVFVRGYSV 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYORG	NP_065753.2	GH31_NET37	314..682	CDD:269878	90/446 (20%)
aagr-2	NP_494897.3	Trefoil	17..58	CDD:238059
		NtCtMGAM_N	69..176	CDD:465286
		GH31_N	175..287	CDD:270212	9/36 (25%)
		GH31_MGAM_SI_GAA	287..687	CDD:269888	95/516 (18%)