DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAML1 and Cont

DIOPT Version :9

Sequence 1:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens
Sequence 2:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster


Alignment Length:1368 Identity:286/1368 - (20%)
Similarity:462/1368 - (33%) Gaps:410/1368 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    93 NSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYV- 156
            |..:|||.:....:.....|.:||....::   |.||...:|.::||.:...:   |.....|| 
  Fly   238 NEDLHDNRFLVQNDLNNQNINNPNQFYNSL---PGTVNQRNQNNLRGFIGPNQ---PYGDNRYVR 296

Human   157 ------------------------------SVVSWEKDTVSI-IPEHRFFITYHGGLYISDVQKE 190
                                          |.|.:..|.|:| :.:.|   .||.||.|:|::: 
  Fly   297 DRVVYAFSKKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKR---PYHYGLDINDMER- 357

Human   191 DALSTYRCITKHKYSGETRQSNGARLSVTGLARAADPLCLPDPAESIPTILDGFHSQEVWAGHTV 255
                    |.:..|.  .:|.|.....|.......|                            |
  Fly   358 --------IPRGPYF--VKQPNDTTFDVNKNRLIND----------------------------V 384

Human   256 ELPCTASGYPIPAIRWLK----DGR-------PLPADSRWTKRITG---LTISDLRTEDSGTYIC 306
            .|.|.|:|||.|:..|.:    |.|       || |..|:|  |:|   :.....:..|.|.|.|
  Fly   385 TLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPL-AQDRYT--ISGGNLIIYEPKQALDQGAYHC 446

Human   307 EVTNTFGSAEAT------GILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTE 365
            ...|.||...:.      |.:|                                ||.::      
  Fly   447 VAENKFGRIRSESAHLNFGFIM--------------------------------EFNLK------ 473

Human   366 LVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV 430
                                                |.|:|::                      
  Fly   474 ------------------------------------RSAETSE---------------------- 480

Human   431 VNPGEQFSLMCAAKGAPP---PTVT--WALDDEPIVRDGSHRTNQYTMSDGT-------TISHMN 483
            :|.|:  |:.|    .||   |.|.  ||.|..|...:...|.  :...||.       |:...|
  Fly   481 MNWGK--SIFC----DPPQHYPDVRYYWARDYFPNFVEEDQRV--FVSRDGALYFSFIETVDRAN 537

Human   484 VTGPQIRDGGVYRCTARNLVG---------------SAEYQARINVRGPPSIRAMRNITAVAGRD 533
                       |.||.:.||.               ::.|||.|.....|.:...   ..|||.:
  Fly   538 -----------YSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPE---APVAGDE 588

Human   534 TLINCRVIGYPYYSIKWYKDALLLPDN------HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ 592
            ..:.|...|||..|..|.:..|.|..|      .|.::.:|.|..        |.|||.|:: ..
  Fly   589 IRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNATTN--------DNGEYSCTI-TN 644

Human   593 PQLSISQSVHVAVKVPP--------LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQ-- 647
            |:.::.:|:::.:::.|        :|:.:......|.:...||        ....||.|:.:  
  Fly   645 PRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIP--------DANYTWYKNAERL 701

Human   648 ---------VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL-IVRVPP 702
                     .||..:.:||:..|          ..|.:..|.|.|.|...|.....|| ::.:.|
  Fly   702 DPANINRDRYIIQDNVLTIKFLE----------KDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKP 756

Human   703 RFVVQPNNQD--GIYGKAGVLNCSVDGYPPPKVMWK---HAKGSGNPQQYHPVPLTGRIQILPNS 762
            .|...|...:  .:|.....:.|..:..|.||..||   ...|||           |..:|||:.
  Fly   757 SFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSG-----------GHRRILPSG 810

Human   763 SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGE 827
            :|.|.....:|.|.|.|.|||..|||.|.:..:.::....|.:.|...::.:.....|:|.|..:
  Fly   811 TLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFD 875

Human   828 RPIIIR--WE------------KGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 878
            ..:.|.  |:            .|..::|.:|:..:..:.:|.||                  :.
  Fly   876 ELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGD------------------YE 922

Human   879 CHAINSYGEDRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDS 942
            |...::..|......::::..|..| .:::.::......:.|.   ||:.  .|..|.|.|....
  Fly   923 CVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWV---DGSH--NGRAIRYYNILGR 982

Human   943 WDFKQSTRNISPTI-----------NQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTI-STEE 995
            .::.::..|:|..:           .||.:|:|.|.|.|...:.:.|.:|...||....| ||.|
  Fly   983 TNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYE 1047

Human   996 AAPDGPPMDVTLQPVTSQSIQVTWK--APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATG 1058
            ..|...|.:|.........:.:||.  .|:::..:|      |.|:            |..|..|
  Fly  1048 DKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHG------IHYK------------VFWKLKG 1094

Human  1059 DSEVYTLDNLKK----------------FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPE 1107
            ..| :..|.:||                :.:|.|.|||.|..|.||.|......:.||:|...|:
  Fly  1095 AIE-WASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQ 1158

Human  1108 NVRALSITSDVAVISWS--EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGME 1170
            ...||:..|....::|.  :..|..:.|.|.|:|:.:|......|........|||....:.|::
  Fly  1159 KPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQ 1223

Human  1171 KFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSW--LPPTKPNGV 1232
            ..|.|.|:|:||..||:|..|.....:|....| .||:.:.....:.|:|.|.|  :.|::....
  Fly  1224 PDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEP 1288

Human  1233 IRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEP 1296
            :..|.: ...|..:...|.:......::|...|.:|..|:.|.:.|.|.::.|.|..|.......
  Fly  1289 VEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQ 1353

Human  1297 AGK 1299
            .||
  Fly  1354 MGK 1356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653 7/25 (28%)
IGc2 43..110 CDD:197706 4/16 (25%)
Ig 125..218 CDD:299845 25/124 (20%)
IG_like 137..209 CDD:214653 19/103 (18%)
I-set 245..323 CDD:254352 26/97 (27%)
IGc2 252..313 CDD:197706 23/74 (31%)
IGc2 340..401 CDD:197706 2/60 (3%)
I-set 420..514 CDD:254352 26/120 (22%)
Ig 420..510 CDD:299845 23/116 (20%)
IGc2 531..589 CDD:197706 18/63 (29%)
IG_like 619..698 CDD:214653 19/90 (21%)
Ig 627..693 CDD:143165 16/76 (21%)
I-set 702..797 CDD:254352 30/99 (30%)
Ig7_DSCAM 719..797 CDD:143211 26/80 (33%)
I-set 803..896 CDD:254352 15/106 (14%)
Ig 815..903 CDD:299845 14/101 (14%)
FN3 899..993 CDD:238020 23/106 (22%)
FN3 1000..1097 CDD:238020 25/114 (22%)
fn3 1105..1191 CDD:278470 25/87 (29%)
FN3 1203..1294 CDD:238020 21/94 (22%)
IGc2 1318..1382 CDD:197706
FN3 1396..1486 CDD:238020
FN3 1500..1572 CDD:238020
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..460 CDD:299845 30/131 (23%)
I-set 362..462 CDD:254352 30/132 (23%)
Ig 466..559 CDD:299845 28/207 (14%)
IG_like 584..657 CDD:214653 22/81 (27%)
IGc2 586..645 CDD:197706 18/67 (27%)
Ig 667..751 CDD:299845 20/101 (20%)
IG_like 676..751 CDD:214653 19/92 (21%)
IG_like 765..844 CDD:214653 27/89 (30%)
Ig 773..844 CDD:299845 26/81 (32%)
I-set 851..940 CDD:254352 15/106 (14%)
Ig 866..944 CDD:299845 13/95 (14%)
FN3 944..1043 CDD:238020 22/103 (21%)
FN3 1053..1146 CDD:238020 25/111 (23%)
fn3 1156..1244 CDD:278470 25/87 (29%)
fn3 1259..1346 CDD:278470 19/86 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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