DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAML1 and Dscam2

DIOPT Version :9

Sequence 1:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	2172	Identity:	666/2172 - (30%)
Similarity:	1023/2172 - (47%)	Gaps:	241/2172 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWLVT---FLLLLDSLHKARPEDVGTSLY---FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRW 59
            ||:.:   .:|||.:|.....|.....|.   ||.:...:|.||:|.|..:.|.|:|||...:.|
  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65

Human    60 YLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFR 124
            ..|.|..:.::..:|.|..||||.|.||:.:|::..:|:..|.|.|.|:.|:|.|.:::|:||..
  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130

Human   125 EPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSW-EKDTVSIIP----EHRFFITYHGGLYI 184
            :.|.|.||...:.||..|:.:|::|:.|:|.|.|||| .:..:.|.|    :.:|.:...|.|.|
  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195

Human   185 SDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT---GLARAADPLCLPDPAESIPTILDGFHS 246
            .::|:.|...::||.:.|:.:.:...|:..||.:.   |:..              |::::....
  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIIS--------------PSVVEHTAH 246

Human   247 QEVWAGHTVELPCTASGYPIPAIRWL--KDGRPLPADSRWTKRITG--LTISDLRTEDSGTYICE 307
            .:|.......|.|.|.|.|.|...|.  ....|||..|....|:.|  |.|..:..||||.|.|.
  Fly   247 VQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCT 311

Human   308 VTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT--GSP--EFTIRWYRNTELVL 368
            ..|..|.|.|...|.|..|:.|.::|..|...:|.|....|.:|  |||  ...|.||::.. .|
  Fly   312 AGNVGGEASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGR-QL 375

Human   369 PDEAISIRGLSNETLLITSAQKSHSGAYQCFATR-KAQTAQDFAIIALEDGTPRIVSSFSEKVVN 432
            |..     |...:||::....:.:.|.|||...| :..|.|..|.:.|.|..|.::.||.|:.:.
  Fly   376 PSS-----GRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQ 435

Human   433 PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC 497
            ||...||.|:|.|.|.|.::|.||..|:..:|.....||....|..|||:|::...:.|||.|.|
  Fly   436 PGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYAC 500

Human   498 TARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR 562
            .|.|..|..::.||:|:.|.|.||.:..:|||:|....:.|.|.|||...|.|.:....|||:.|
  Fly   501 IAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIR 565

Human   563 QVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE--FPPASIGQLL 625
            |.|..:|:|.::.|||..|.|.|.|....:...|..:|..|.|.|||.:.||:  ....::|...
  Fly   566 QRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRA 630

Human   626 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIES-KEFMSSLQISSVSLKHNGNYTCIASNAAAT 689
            .:.|.|..||:|:.|.|||||:.|.....::::. .::.|.|.|.::...|.|||:|:..|:||.
  Fly   631 SLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAE 695

Human   690 VSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG--SGNPQQYHPVPL 752
            |...:.|:|.||||::|:|.:.:....:..:|:|...|.|.|.::||.|.|  ||..::....|.
  Fly   696 VENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPF 760

Human   753 TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHA 817
            |   ::|.|.|||::||.|:..|:|||||:||:||.|.|.:.|.|......:|...:.:..||..
  Fly   761 T---KLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDT 822

Human   818 KELNCTARGERPIIIRW-EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 881
            ..|.|...|::||.|.| ..|...::|....:.::..:...|.|.:.|:::..|..||..:.|.|
  Fly   823 ALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRA 887

Human   882 INSYGEDRGLIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKS----- 940
            .|.||.|:.|:||.|||||.||. ||...:.:||:|::|..:..|...:|.:.:|::...
  Fly   888 SNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPP 952

Human   941 ----DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGP 1001
                |.|   |......|....|.|.:|.||:.|:.|:.:....|||.||:||.:.||...|.||
  Fly   953 ALFVDQW---QQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGP 1014

Human  1002 PMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD--SEVYT 1064
            |:.::.:|::|..:.::|.||..||::|.|:||.:||:.:|.| |..|:...:...||  :....
  Fly  1015 PLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSG-NTAYNFTSVSGDGDGGNGELL 1078

Human  1065 LDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRS 1129
            |..|.|||:|.|||||||:.|.||.|....|.|:|||||:|||:||..:::|....:||..||..
  Fly  1079 LSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIY 1143

Human  1130 TLNGVLKGYRVIFWSLY--VDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSS 1192
            ..||:|:||::||..:.  :.....|:::..||...:.|.|:.|:||||:||||:|:.||||.|.
  Fly  1144 HTNGLLQGYKLIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSK 1208

Human  1193 VLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP 1257
            .|:..::||||..||.||.|.||:.|:.:|||||.:|||||.||:::.......:...:|..:.|
  Fly  1209 PLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLP 1273

Human  1258 -EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1321
             :|.:|....|:...:|..||.|.|..|.|.||...:.....:.||:||||||.|..||...|.|
  Fly  1274 SQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTL 1338

Human  1322 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-----NGTLLLRAVKAEDSGYYTCTATNTG 1381
            ||.:||.|..  :|.|    |.:.:...|   :|.     :|.|::.:::..|.|.|:|...|..
  Fly  1339 PCTAVGKPKR--EWFK----SDVALRQGG---LHNSQLLDSGDLIISSLQLADGGNYSCQVDNGI 1394

Human  1382 GFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQY--SVDNSEEWKDVF 1444
            |.|.:...|:|||||..|.|.|:..::|||.:.|..|..|.:.|.|:.|.|  :..|::|.:
  Fly  1395 GTDRLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQ--- 1456

Human  1445 ISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHAR 1509
            :|....|.:|..|.||:.|::.|:|:|.||:...|.|:..:|.|:.|.......|... |||...
  Fly  1457 LSRHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLL 1520

Human  1510 LNLQGWNNGGCPITAIVLEYR-----PKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSA 1569
            :.|..|.:.|||:...||:||     |...|............:.:..|:.:|.|:|||.|.|.|
  Fly  1521 VRLHSWPDNGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVA 1585

Human  1570 GCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLF---TIGCPVILATLGV--ALLFIVRKKRK 1629
            |.......|.||..||...||....:|.......:|   .:..|.|.|..|:  .::.|:...|
  Fly  1586 GISQAEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYR- 1649

Human  1630 EKRLKRLRDAKSLAEM-LISK---NNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDD 1690
                ..|::|..|||. .|.|   .||:.....    |..|.:..|.:|.:...||
  Fly  1650 ----HMLKNAPPLAEQSQIQKESLENRANSEAA----QRERYYATIHKVSMQNNDK--------- 1697

Human  1691 KATIPVTDAEFSQAVNPQSFCTGVSLHHP-------TLIQS----TGPLIDMSDIRPGTNPVSRK 1744
               ||.|..:.|.....|....|.::..|       ||:.|    ...|.:.....|   |.:.|
  Fly  1698 ---IPETSEDISPYATFQLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPP---PAASK 1756

Human  1745 NVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNS 1809
            | :..||.:....|:      ::.:....|||                 |.:.|.:|...|.::|
  Fly  1757 N-RRRHSRKTEPESE------ESESDQDQLTS-----------------SRTESSNQHEGKIKHS 1797

Human  1810 MVSTESASSTYEELARAYEHAKL----EEQLQHAKFEI-TECFISDSSSDQMTTGT--NENADSM 1867
            ::...:.|||..:|:...|...|    ..:..|.:::. |.......:|::|...|  |.|..:.
  Fly  1798 IIYHGAQSSTSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTAT 1862

Human  1868 TSMSTPSEPGICRFTASPPKPQDADRGKNV-AVPIPHRANKSDYCNLPLYAKSEAFFRKADGREP 1931
            .:.:|||.........||       ||.|: ::....::..|..|::|...||.:...:..
  Fly  1863 NTTATPSTSSNSNKILSP-------RGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQ---- 1916

Human  1932 CPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHP---------------------GAPAA 1975
                  ::...:.|..:....::|.:.:|.|.||....|                     |...:
  Fly  1917 ------KQFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNS 1975

Human  1976 ASTATLPQRTLAMPAP-----PAGTAP------------------PAPGPTPAEPPTAPSA---- 2013
            ...|.:|..:...|.|     ||...|                  ..|| |...|.||..:
  Fly  1976 PLVACMPPSSQFRPIPHKSIMPAHEPPHHHNHSQQSHPHQQQQQQQHPG-TLLNPSTAMLSSKFF 2039

Human  2014 -APPAPSTEPPRAGGPHTKMGGSRDSL 2039
             ||..|. :....|..:  :||:.:::
  Fly  2040 TAPTLPKXDTANGGSEY--VGGAMEAM 2064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653	26/75 (35%)
		IGc2	43..110	CDD:197706	23/66 (35%)
		Ig	125..218	CDD:299845	30/97 (31%)
		IG_like	137..209	CDD:214653	23/76 (30%)
		I-set	245..323	CDD:254352	27/81 (33%)
		IGc2	252..313	CDD:197706	22/64 (34%)
		IGc2	340..401	CDD:197706	19/64 (30%)
		I-set	420..514	CDD:254352	35/93 (38%)
		Ig	420..510	CDD:299845	33/89 (37%)
		IGc2	531..589	CDD:197706	23/57 (40%)
		IG_like	619..698	CDD:214653	26/79 (33%)
		Ig	627..693	CDD:143165	24/66 (36%)
		I-set	702..797	CDD:254352	38/96 (40%)
		Ig7_DSCAM	719..797	CDD:143211	34/79 (43%)
		I-set	803..896	CDD:254352	27/93 (29%)
		Ig	815..903	CDD:299845	30/88 (34%)
		FN3	899..993	CDD:238020	31/103 (30%)
		FN3	1000..1097	CDD:238020	40/98 (41%)
		fn3	1105..1191	CDD:278470	36/87 (41%)
		FN3	1203..1294	CDD:238020	35/91 (38%)
		IGc2	1318..1382	CDD:197706	19/68 (28%)
		FN3	1396..1486	CDD:238020	30/91 (33%)
		FN3	1500..1572	CDD:238020	24/76 (32%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	27/75 (36%)
		Ig	138..>203	CDD:299845	20/64 (31%)
		I-set	238..327	CDD:254352	28/88 (32%)
		Ig	247..327	CDD:299845	27/79 (34%)
		I-set	332..418	CDD:254352	26/91 (29%)
		IGc2	344..407	CDD:197706	20/68 (29%)
		IG_like	432..517	CDD:214653	31/84 (37%)
		IGc2	436..507	CDD:197706	28/70 (40%)
		I-set	521..610	CDD:254352	33/88 (38%)
		IGc2	533..597	CDD:197706	23/63 (37%)
		Ig	630..699	CDD:143165	24/68 (35%)
		IG_like	714..802	CDD:214653	35/90 (39%)
		Ig	725..802	CDD:299845	34/79 (43%)
		Ig	823..894	CDD:143165	20/70 (29%)
		FN3	906..1006	CDD:238020	30/102 (29%)
		FN3	1013..1111	CDD:238020	40/98 (41%)
		FN3	1119..1209	CDD:238020	37/89 (42%)
		FN3	1219..1313	CDD:238020	35/93 (38%)
		Ig	1336..1402	CDD:143165	21/74 (28%)
		FN3	1409..1498	CDD:238020	30/91 (33%)
		FN3	1515..1588	CDD:238020	24/72 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4888
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	968	1.000	Inparanoid score	I322
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8541
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.980