DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAML1 and DIP-theta

DIOPT Version :9

Sequence 1:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens
Sequence 2:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster


Alignment Length:649 Identity:132/649 - (20%)
Similarity:221/649 - (34%) Gaps:167/649 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   382 TLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA 446
            |:.....::..:|..|    ||.:..:..:.:.:...|..:||.....:..||      |||:.:
  Fly    14 TIAARRQRRRAAGKLQ----RKREMPEISSRLIVATATAAVVSIICLSLALPG------CAAQES 68

Human   447 PPPTVTWALDDEPIVR--DGSHRTNQ-YTMSDGTTISHM--NVTGPQIRD---GGVYRCTARNLV 503
                     |||..:.  |..|..:| :.:.:.....|:  ::...|.:|   ..:...|..|.:
  Fly    69 ---------DDEGELHHLDQMHHQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIREDTVVNAI 124

Human   504 GSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK---DALLLPDNHRQVV 565
            ...:.        |.....::|:|....|:.::.|.|.....|.|.|.:   ..:|...||  |:
  Fly   125 PEKDL--------PKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNH--VI 179

Human   566 FENGTLKLTDVQ-----------KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA 619
            .:|..:.:|..:           |..|:|.|:|.:...|..  ||..::.|.|||.|  .::|  
  Fly   180 TKNHRMSITHAEKRAWILRIRDVKESDKGWYMCQINTDPMK--SQVGYLDVVVPPDI--LDYP-- 238

Human   620 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIAS 684
                        :|.||.||           .||.||                            
  Fly   239 ------------TSTDMVIR-----------EGSNVT---------------------------- 252

Human   685 NAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHP 749
                                                |.|:..|.|.|.:.|:...|     :..|
  Fly   253 ------------------------------------LKCAATGSPTPTITWRREGG-----ELIP 276

Human   750 VPLTGRIQILPNSSLL-IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAI 813
            :| .|...:..|.|.| |..|...::|.|||.||||:...:||.:.|.|..|.||........|.
  Fly   277 LP-NGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAA 340

Human   814 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFS 878
            ......|.|.:......|..|.|.||:|.|..  |:...|.::|.::...|.:...|..|...:.
  Fly   341 LTQNITLECQSEAYPKSINYWMKNDTIIVPGE--RFVPETFESGYKITMRLTIYEVDIQDFGAYR 403

Human   879 CHAINSYGEDRGLIQL-----TVQEPPDPPELEIREVKARSMNLRWTQRFDG--NSIITGFDIEY 936
            |.|.||.|:..|.|:|     |.......|.:.|..|....:.....||:..  ||....::...
  Fly   404 CVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVPVVLVKYNKEQRYGSSQNSNTNPYNFNP 468

Human   937 KNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDG 1000
            .|...:...::...|...:       |..|:.:.::.:.:.:.:..|:.....:.|:..|:..|
  Fly   469 GNSQQNTKLQRGKSNSKGS-------DQSPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASSRG 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653
IGc2 43..110 CDD:197706
Ig 125..218 CDD:299845
IG_like 137..209 CDD:214653
I-set 245..323 CDD:254352
IGc2 252..313 CDD:197706
IGc2 340..401 CDD:197706 3/18 (17%)
I-set 420..514 CDD:254352 18/101 (18%)
Ig 420..510 CDD:299845 18/97 (19%)
IGc2 531..589 CDD:197706 17/71 (24%)
IG_like 619..698 CDD:214653 9/78 (12%)
Ig 627..693 CDD:143165 9/65 (14%)
I-set 702..797 CDD:254352 26/95 (27%)
Ig7_DSCAM 719..797 CDD:143211 26/78 (33%)
I-set 803..896 CDD:254352 25/97 (26%)
Ig 815..903 CDD:299845 24/92 (26%)
FN3 899..993 CDD:238020 12/95 (13%)
FN3 1000..1097 CDD:238020 1/1 (100%)
fn3 1105..1191 CDD:278470
FN3 1203..1294 CDD:238020
IGc2 1318..1382 CDD:197706
FN3 1396..1486 CDD:238020
FN3 1500..1572 CDD:238020
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 23/96 (24%)
IG_like 137..230 CDD:214653 23/96 (24%)
IG_like 240..324 CDD:214653 35/164 (21%)
IGc2 247..310 CDD:197706 24/132 (18%)
Ig 327..419 CDD:299845 26/93 (28%)
IG_like 343..420 CDD:214653 22/78 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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