DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DSCAML1 and DIP-kappa

DIOPT Version :9

Sequence 1:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens
Sequence 2:NP_723828.1 Gene:DIP-kappa / 318958 FlyBaseID:FBgn0051814 Length:672 Species:Drosophila melanogaster


Alignment Length:356 Identity:94/356 - (26%)
Similarity:143/356 - (40%) Gaps:80/356 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   517 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQVVFENGTLKLT------ 574
            |.....:.|:|...|||.|:.|.|.....|.:.|.: |...:...|..|:.:|..:.||      
  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138

Human   575 ------DVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSS 633
                  :|:: .|.|.|:|.|...|..  |:..::.|.|||:|..                .::|
  Fly   139 WYLHIKEVEE-TDRGWYMCQVNTDPMR--SRKGYLQVVVPPIIVE----------------GLTS 184

Human   634 GDMPIR------------------ITWRK-DG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGN 678
            .||.:|                  :.||: || :::|.|..|.:...|.   |.|:.||..|...
  Fly   185 NDMVVREGQNISLVCKARGYPEPYVMWRREDGEEMLIGGEHVNVVDGEL---LHITKVSRLHMAA 246

Human   679 YTCIASNAA-ATVSRERQLIVRVPPRFVVQPNNQDGIY-GKAGVLNCSVDGYPPPKVMWKHAKG- 740
            |.|:|||.. .::|:...|.|:.||...: ||..:|.| |:..:|.|..:.||.....|...:| 
  Fly   247 YLCVASNGVPPSISKRVHLRVQFPPMLSI-PNQLEGAYLGQDVILECHTEAYPASINYWTTERGD 310

Human   741 ------SGNPQQYHPV-PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG-TDISKSMFLTV 797
                  |....:|... .::|..:.:   .|.||.|...|.|.|.|.|.|.:| ||.:      :
  Fly   311 MIISDTSRAGDKYETTSTVSGYTKYM---KLKIRAVGPNDFGTYRCVAKNSLGETDGN------I 366

Human   798 KIPAMITSHPNTTIAIKGHAKELNCTARGER 828
            |:..|    |..|.||......||.:..|:|
  Fly   367 KLDEM----PTPTTAIISEMSLLNRSYDGKR 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653
IGc2 43..110 CDD:197706
Ig 125..218 CDD:299845
IG_like 137..209 CDD:214653
I-set 245..323 CDD:254352
IGc2 252..313 CDD:197706
IGc2 340..401 CDD:197706
I-set 420..514 CDD:254352
Ig 420..510 CDD:299845
IGc2 531..589 CDD:197706 19/70 (27%)
IG_like 619..698 CDD:214653 24/99 (24%)
Ig 627..693 CDD:143165 23/86 (27%)
I-set 702..797 CDD:254352 28/104 (27%)
Ig7_DSCAM 719..797 CDD:143211 22/86 (26%)
I-set 803..896 CDD:254352 8/26 (31%)
Ig 815..903 CDD:299845 4/14 (29%)
FN3 899..993 CDD:238020
FN3 1000..1097 CDD:238020
fn3 1105..1191 CDD:278470
FN3 1203..1294 CDD:238020
IGc2 1318..1382 CDD:197706
FN3 1396..1486 CDD:238020
FN3 1500..1572 CDD:238020
DIP-kappaNP_723828.1 Ig 80..172 CDD:299845 24/94 (26%)
IG_like 82..174 CDD:214653 25/94 (27%)
IG_like 184..267 CDD:214653 24/85 (28%)
IGc2 191..255 CDD:197706 18/66 (27%)
IG_like 282..368 CDD:214653 24/94 (26%)
Ig 288..367 CDD:143165 22/87 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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