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Protein Alignment DSCAML1 and Dscam4

DIOPT Version :9

Sequence 1:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	1950	Identity:	617/1950 - (31%)
Similarity:	932/1950 - (47%)	Gaps:	218/1950 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    27 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRW--YLATGDDIYDVPHIRHVHANGTLQLYPFSP 89
            |:::...:|.||::.|.::.|...|||...:.|  .....|.::.:       :||::..|||:.
  Fly    34 FLHEPPHRVEFSNNSGGLIECSGHGSPPPEVEWTPIPPQQDMVFQL-------SNGSMMFYPFTA 91

Human    90 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQE 154
            ..:...:|...|.|...|..|.:.|..:.|:.|..:.|.|:|.|:..|.||.||.||.:||.:.|
  Fly    92 EKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVNQKYAVQVHDEYVMTGNTAVLKCQVPSYMSE 156

Human   155 YVSVVSWEKDT-VSIIPE----HRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN-G 213
            :|.|.:|.:|| :.:.|.    .::.:..:|.|||::....||..:|.|.|.::.:||.:.|. .
  Fly   157 FVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPNDAYKSYTCRTVNRLTGEVQISTYP 221

Human   214 ARLSVTGLARAADPLCLPDPAESIPTILDGFHSQE--VWAGHTVELPCTASGYPIPAIRWLKDGR 276
            .|:.||      :|..:..|..::..     ||..  |..|.|. |||.|.|:|:|..||.|:..
  Fly   222 GRIIVT------EPKGMVQPRINVEK-----HSMRHVVLNGQTT-LPCIAQGHPVPTYRWFKEEN 274

Human   277 ----PLPADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 336
                ||....|.|....| |.|:..|.||||.|:|.|.||.|.......|.|..||...|.|:..
  Fly   275 EQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAPLTAHLQPQVQ 339

Human   337 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-ETLLITSAQKSHSGAYQCFA 400
            ...:.......|.::|.|...:.|..:.:.:|.|..:.|  |:: ..|:|...||...|.||||.
  Fly   340 TVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEI--LTDPPRLIIKKVQKEDPGMYQCFV 402

Human   401 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGS 465
            :.:.:..|..|.:.|.|.:|.::..|||:.:.||...||.|.|.|.|.|..||:||..||.....
  Fly   403 SNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSR 467

Human   466 HRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA 530
            ....||.......|||:|::..:..|||.|.|||:|.:|...:.|::|:.|.|.||.|..||.::
  Fly   468 FLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGIS 532

Human   531 GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 595
            |.|.::.|.|.|||...|.|.:|...||.|.||..:.||||.:..:|:..|.|.|.|....:.:.
  Fly   533 GSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQ 597

Human   596 SISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDGQVII-SGSGVTI 657
            :..::|.:.|.|||.|.|.:.....:  |....|.|.:..||:|:...|.::|:.:| :|:.|..
  Fly   598 TSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFR 662

Human   658 ESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLN 722
            ...|:.:||.|..:|..|:|||||||||.|.|......|.|.|||:::::|.:.....|...:|:
  Fly   663 RLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEPKDSSAQAGADVLLH 727

Human   723 CSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGT 787
            |...|||.|.:.||.|.|. .|.:|........:|:.||.::..:.:.:|..|::||:|.|.:|:
  Fly   728 CQSSGYPTPTITWKKAIGP-TPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGS 791

Human   788 DISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDT--VIDPDRVMRYA 850
            .:||.:||.|.:||...:........||....:.|..:|:.||..:|:...|  .:|.....||.
  Fly   792 GVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYT 856

Human   851 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE-LEIREVKARS 914
            |..:...|.:||.|.:....|.|:..:.|.|.|::|:|...|||.|||.|:.|: |.|...::||
  Fly   857 IRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRS 921

Human   915 MNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQA----NIVDLHPASVYSIRMY 975
            :.|.|:|.|.|||.|..:.|.||..||.|   |:..::  ||..|    ||..|.||..|.|||.
  Fly   922 LQLTWSQPFAGNSPIEEYHIYYKQISDIW---QNAEHL--TIAGAQTVINIQQLRPAKAYHIRMS 981

Human   976 SFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGY-- 1038
            :.||:|.||.|:.:.::|.|..|.|||:.|..:|.:|..|.|||.||:::..||::.||.:||
  Fly   982 AENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQM 1046

Human  1039 ------RENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATT 1097
                  :|.:|.....:..||:::....|. .|.||.||.||.|:|||:...|:||.|.||...|
  Fly  1047 SLTPEDKEVNPTQGFSFKTVEVRSHFGGET-VLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQT 1110

Human  1098 LEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWS---LYVDGEWGEMQNITT 1159
            :|||||.|||:.:...:.|....|:||.|.....||.:|||:|.:.|   ||..    :.:.:.:
  Fly  1111 MEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYET----DPEVVKS 1171

Human  1160 TRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWL 1224
            |.:.|.:..:.|:|||:|.|||||:.|||:::...|.:|.||||..|..|||:|:|:|.:::|||
  Fly  1172 TNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWL 1236

Human  1225 PPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQL--FYRIAHLNRGQQ---YLLWVAAVTSAG 1284
            ||..|||.|..||.:.|....|:    |..|....|  |..:....|.|:   |..|:.|.|..|
  Fly  1237 PPDLPNGDITGYTFYMSMLEGGR----EEGTHKRLLGPFVEMHETVRTQESATYQFWLTASTKMG 1297

Human  1285 RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1349
            .|..::.||:.|..|.||:|:||...:.|||.:.:.|||..||.|||...|.:|..:    :...
  Fly  1298 EGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHN----METS 1358

Human  1350 GHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLT 1414
            ..:.|..||||.::..:|.|:|.|||:..||.|.|.|:.|::|:|||:.|.|||......|:.|.
  Fly  1359 ARKTIAKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVKVPPEAPNLTVINAYTDSLLLE 1423

Human  1415 WIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1479
            |:...:|||.|.|:|:.|..||. :|:::.:.|...|..|.:|.|||.|::.:.|.|.:|:|...
  Fly  1424 WMDNSHGGSPILGYVINYKRDNG-DWEELQVDSKTTSHLLTNLWCGTRYQLYITAYNKIGTGLPC 1487

Human  1480 EIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKG--TWAWQGLRA 1542
            :|:.:.|.|..|...|...:.|: |||.....|..|.:|||.|...::|.|..|  :||......
  Fly  1488 DIVNSYTKGNPPVQPKHSQMITN-NSTSVTCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHI 1551

Human  1543 NSSGEVF-LTELREATWYELRMRACNSAGCGNETAQFATLDYDG--------------STIPPIK 1592
            ..:..:: :::|...|.|:|::.|.|:||.......|.||...|              |.:|...
  Fly  1552 PPTERIYTVSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLPFYA 1616

Human  1593 SAQGEGDDVKKLFTIGCPV------ILATLGVALLFIVRKKRKEKRL--KRLRDAKSLAEMLISK 1649
            :           |.:..|:      :||.:|.||....||...:.||  ..:.::.|||. |.:|
  Fly  1617 N-----------FKLLLPICFSLLMLLALIGAALFLRKRKLASQARLASSSMSESPSLAN-LQNK 1669

Human  1650 NNRSFD------TPVKGPPQGPRLHIDIPRVQLLIEDK------EGIKQLGD--DKATIPVTDAE 1700
            .||...      .|....|:|...:           |.      ||.:.:.|  ..||..:....
  Fly  1670 QNRDQQYLAVRCNPGTSAPRGSNSN-----------DSGSFGKAEGNEYIEDICPYATFQLNKQT 1723

Human  1701 FSQA-------VNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHSTRNRYSS 1758
            :|::       ..|.....|..::|              |::|          :|.||....|
  Fly  1724 YSESSYSGNVYSGPYHSVRGSFVYH--------------DVKP----------ESYHSKEPEY-- 1762

Human  1759 QWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQD----TDKGRNSMVSTESASST 1819
                ||.:            |.||...       |.:|.|...|    ||.....:::.....:.
  Fly  1763 ----TKVR------------RKVGRLR-------DPHSESQESDNPGSTDSEVRKILTLHIPITE 1804

Human  1820 YEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTP-------SEPG 1877
            |:.|....::......|..||:........::||...||.|     |||..|.|       .:||
  Fly  1805 YDTLGSESDNDVSARALNSAKYRAQRDTQDETSSSSETTPT-----SMTRKSKPPFAARKGGKPG 1864

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.