DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAML1 and dscaml1

DIOPT Version :9

Sequence 1:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens
Sequence 2:	XP_004916122.1	Gene:	dscaml1 / 100491996	XenbaseID:	XB-GENE-922538	Length:	2043	Species:	Xenopus tropicalis

Alignment Length:	2069	Identity:	1772/2069 - (85%)
Similarity:	1896/2069 - (91%)	Gaps:	30/2069 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGD 65
            |.||| |.||.|:|.|..||.||||||||.||.|:||||:|||.:||||||||||.|||||.|||
Frog     1 MLLVT-LSLLCSVHLAHLEDAGTSLYFVNTSLLQITFSSTVGVFIPCPAAGSPSATLRWYLGTGD 64

Human    66 DIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVR 130
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Frog    65 DIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENSAGKIRSPNIRVKAVFREPYTVR 129

Human   131 VEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALST 195
            |||||:|||:.||||||.|.|||||||||||||||||:..|.||..:..|.|||.||||||||||
Frog   130 VEDQRAMRGSAAVFKCLTPPSVQEYVSVVSWEKDTVSLTSEGRFVTSPSGALYILDVQKEDALST 194

Human   196 YRCITKHKYSGETRQSNGARLSVTGLARAADPLCLPDPAESIPTILDGFHSQEVWAGHTVELPCT 260
            |||||:|:|||||||||||||.|:            |||||:|.:||||.|||...|.||||||.
Frog   195 YRCITRHRYSGETRQSNGARLLVS------------DPAESVPVLLDGFQSQEALVGETVELPCI 247

Human   261 ASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 325
            |||||..|.||:|||||:|:||||:||.|||:::|||.|||||||||:||:|||||.||.|.||:
Frog   248 ASGYPNLASRWIKDGRPVPSDSRWSKRSTGLSMADLRLEDSGTYICEITNSFGSAEVTGTLTVIE 312

Human   326 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 390
            ||.|||:||||||||||||||||:|:|||.:.:|||||||.:..||.|||||..||||:|:||||
Frog   313 PLRVTLSPKKLKTGIGSTVILSCSLSGSPGYIVRWYRNTEHIEADEFISIRGADNETLVISSAQK 377

Human   391 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 455
            |||||||||.|||.||||||||:.||||||||:|||||||:||||||||||:||||||||:||.|
Frog   378 SHSGAYQCFGTRKKQTAQDFAIVVLEDGTPRILSSFSEKVMNPGEQFSLMCSAKGAPPPTITWTL 442

Human   456 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 520
            |||||.||..||:||||.:||:|:|:|||:.|||.|||||||.|||.||||||||||||||||||
Frog   443 DDEPIQRDSGHRSNQYTTADGSTVSYMNVSSPQILDGGVYRCAARNSVGSAEYQARINVRGPPSI 507

Human   521 RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEY 585
            |.|:|:|||||||:.|:|||||||||.|.||||:|||||||||||||||||.|:|||||||||||
Frog   508 RPMKNLTAVAGRDSFIHCRVIGYPYYFISWYKDSLLLPDNHRQVVFENGTLMLSDVQKGMDEGEY 572

Human   586 LCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVII 650
            ||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||:
Frog   573 LCSVLIQPQLSISQSVHVTVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIV 637

Human   651 SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY 715
            ||||:|||:||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Frog   638 SGSGITIETKEFMSSLQISSVSLKHNGNYTCIASNDAATVSRERQLIVRVPPRFVVQPNNQDGIY 702

Human   716 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 780
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
Frog   703 GKAGVLNCSVDGYPPPKVVWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 767

Human   781 ASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDR 845
            |||||||||||||||||||||||||||||||||||..|.||||||||||||||||||||||||||
Frog   768 ASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGQTKGLNCTARGERPIIIRWEKGDTVIDPDR 832

Human   846 VMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREV 910
            .:||.|||||:||||:|||.||||:||||||||||||||||||||||||||||||||||||:|||
Frog   833 NLRYLIATKDSGDEVISTLTLKPAERGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEVREV 897

Human   911 KARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY 975
            ||||||||||||||||||||.||||||||||||:||||||||||.||||||||||||||||||||
Frog   898 KARSMNLRWTQRFDGNSIITAFDIEYKNKSDSWEFKQSTRNISPIINQANIVDLHPASVYSIRMY 962

Human   976 SFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRE 1040
            ||||||||||||||||||||||||||||||||||:||||||||||||:|||||||||||||||||
Frog   963 SFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPLTSQSIQVTWKAPRKELQNGVIRGYQIGYRE 1027

Human  1041 NSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQP 1105
            |.|||||||||||||||||:|||||||:||||||||||||||||||||||:||||||||||||:|
Frog  1028 NGPGSNGQYSIVEMKATGDAEVYTLDNMKKFAQYGVVVQAFNRAGTGPSSTEINATTLEDVPSKP 1092

Human  1106 PENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGME 1170
            |||||.|||||||||||||||||::||||||||||||||||.||||||||||||.||||||:.:|
Frog  1093 PENVRVLSITSDVAVISWSEPPRNSLNGVLKGYRVIFWSLYPDGEWGEMQNITTPRERVELKSLE 1157

Human  1171 KFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRK 1235
            |||:|||||||||||||||||.|||:|||||:||||||||||.||:|||||||||||||||:|||
Frog  1158 KFTDYSVQVLAYTQAGDGVRSDVLYLQTKEDIPGPPAGIKAVSSSSSSVVVSWLPPTKPNGIIRK 1222

Human  1236 YTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1300
            |||||||||||||||||||||||.|.|||.||.|||||:|||||||||||||.||||.|||||||
Frog  1223 YTIFCSSPGSGQPAPSEYETSPEFLHYRIMHLLRGQQYMLWVAAVTSAGRGNFSEKVMIEPAGKA 1287

Human  1301 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAV 1365
            |||||||||||:|||||||||||:|||:||||:|||||||||||||::|||||||:||||.||:|
Frog  1288 PAKIISFGGTVSTPWMKDVRLPCSSVGEPAPAIKWTKDSEDSAIPVALDGHRLIHSNGTLTLRSV 1352

Human  1366 KAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVL 1430
            |||||||||||||||.||||||||||||||||||||||||||||||||.||||||||||||||||
Frog  1353 KAEDSGYYTCTATNTWGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLAWIPGDNGGSSIRGFVL 1417

Human  1431 QYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSK 1495
            ||||||||||:|||||||||||:|::|:||||||||||||||||:||||||||||||||||||:|
Frog  1418 QYSVDNSEEWRDVFISSSERSFRLENLRCGTWYKVKLAAKNSVGAGRISEIIEAKTHGREPSFNK 1482

Human  1496 DQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYE 1560
            ||.||||:|||||||||.|||:||||||:::|||||:.||.||.||||.:.:|||||||||||||
Frog  1483 DQPLFTHVNSTHARLNLHGWNSGGCPITSVILEYRPQNTWPWQSLRANVTSDVFLTELREATWYE 1547

Human  1561 LRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVR 1625
            |:|||||||||||||::||||||||||||||||||||||||||||:|..||||||||||||||:|
Frog  1548 LKMRACNSAGCGNETSRFATLDYDGSTIPPIKSAQGEGDDVKKLFSIASPVILATLGVALLFIIR 1612

Human  1626 KKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQL-GD 1689
            |||||||||||||||||||||||||||||||||||||.||||||||||||||||||||:||| ||
Frog  1613 KKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPAGPRLHIDIPRVQLLIEDKEGVKQLAGD 1677

Human  1690 DKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHSTRN 1754
            ||||:|||||||||.|||||||||||||||.|||:||||||||||||||||||||:|||||||||
Frog  1678 DKATLPVTDAEFSQTVNPQSFCTGVSLHHPALIQNTGPLIDMSDIRPGTNPVSRKSVKSAHSTRN 1742

Human  1755 RYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVSTESASST 1819
            ||||||||||||:|||||||||||||||||||:||||||||||||||||||||||||||||||||
Frog  1743 RYSSQWTLTKCQSSTPARTLTSDWRTVGSQHGITVTESDSYSASLSQDTDKGRNSMVSTESASST 1807

Human  1820 YEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPGICRFTAS 1884
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
Frog  1808 YEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENGDSMTSMSTPSEPGICRFTAS 1872

Human  1885 PPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTY 1949
            ||||||:|..||||||||||| ||:|||||||.|||..|||.|..:.||||||||||:|||.|:|
Frog  1873 PPKPQDSDPTKNVAVPIPHRA-KSEYCNLPLYMKSEPHFRKPDPHDSCPVVPPREASMRNLNRSY 1936

Human  1950 HTQARHLTLDPASK-SLGLPHPGAPAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSA 2013
            |  :|||||:|.:| ..||.|| .|:..|   ||||||.:    ||.:..||....|..|:||
Frog  1937 H--SRHLTLEPGAKPPPGLSHP-TPSGVS---LPQRTLLL----AGASASAPSAPAATAPSAP-- 1989

Human  2014 APPAPSTEP--PRAGGPHTKMGGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV 2065
            |.|.||..|  .|....|:|||||||||||||:||..|:|||||||||||||||
Frog  1990 ADPTPSVGPVENRLPTQHSKMGGSRDSLLEMSSSGGSRAQKQGAGAYSKSYTLV 2043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653	70/75 (93%)
		IGc2	43..110	CDD:197706	61/66 (92%)
		Ig	125..218	CDD:299845	74/92 (80%)
		IG_like	137..209	CDD:214653	54/71 (76%)
		I-set	245..323	CDD:254352	55/77 (71%)
		IGc2	252..313	CDD:197706	44/60 (73%)
		IGc2	340..401	CDD:197706	45/60 (75%)
		I-set	420..514	CDD:254352	74/93 (80%)
		Ig	420..510	CDD:299845	70/89 (79%)
		IGc2	531..589	CDD:197706	49/57 (86%)
		IG_like	619..698	CDD:214653	74/78 (95%)
		Ig	627..693	CDD:143165	61/65 (94%)
		I-set	702..797	CDD:254352	93/94 (99%)
		Ig7_DSCAM	719..797	CDD:143211	76/77 (99%)
		I-set	803..896	CDD:254352	82/92 (89%)
		Ig	815..903	CDD:299845	77/87 (89%)
		FN3	899..993	CDD:238020	89/93 (96%)
		FN3	1000..1097	CDD:238020	90/96 (94%)
		fn3	1105..1191	CDD:278470	76/85 (89%)
		FN3	1203..1294	CDD:238020	81/90 (90%)
		IGc2	1318..1382	CDD:197706	55/63 (87%)
		FN3	1396..1486	CDD:238020	82/89 (92%)
		FN3	1500..1572	CDD:238020	56/71 (79%)
dscaml1	XP_004916122.1	Ig	42..113	CDD:319273	65/70 (93%)
		Ig	128..217	CDD:386229	70/88 (80%)
		I-set	232..310	CDD:369462	55/77 (71%)
		IG_like	328..388	CDD:214653	44/59 (75%)
		Ig_3	407..488	CDD:372822	62/80 (78%)
		Ig	504..574	CDD:386229	58/69 (84%)
		Ig	614..680	CDD:319273	61/65 (94%)
		Ig_DSCAM	706..784	CDD:143211	76/77 (99%)
		Ig	802..890	CDD:386229	77/87 (89%)
		FN3	886..980	CDD:238020	89/93 (96%)
		FN3	987..1084	CDD:238020	90/96 (94%)
		FN3	1092..1185	CDD:238020	81/92 (88%)
		FN3	1190..1281	CDD:238020	81/90 (90%)
		IGc2	1305..1369	CDD:197706	55/63 (87%)
		FN3	1383..1473	CDD:238020	82/89 (92%)
		FN3	1487..1563	CDD:238020	60/75 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	954	1.000	Domainoid score	I753
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H79549
Inparanoid	1	1.050	3579	1.000	Inparanoid score	I149
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	1	1.000	-	-		FOG0003568
OrthoInspector	1	1.000	-	-		oto147783
Panther	1	1.100	-	-	LDO	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160