DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DSCAML1 and dscaml1

DIOPT Version :9

Sequence 1:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens
Sequence 2:	XP_005157551.1	Gene:	dscaml1 / 100002762	-ID:	-	Length:	2158	Species:	Danio rerio

Alignment Length:	2112	Identity:	1730/2112 - (81%)
Similarity:	1876/2112 - (88%)	Gaps:	70/2112 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWLVTFLLLLDSLHKARPED-VGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATG 64
            ||||| ||||.|..:...|| |.|.|||||.|||:|||||||||.:||||.|:|.|.||||||||
Zfish    70 MWLVT-LLLLYSFQEVHSEDVVSTRLYFVNASLQRVTFSSSVGVSLPCPAGGAPHAVLRWYLATG 133

Human    65 DDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTV 129
            |||||||||||||||||||||||||||||||||||||||||||.|||||||:|||||||||||||
Zfish   134 DDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENQAGKIRSPSIRVKAVFREPYTV 198

Human   130 RVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALS 194
            ||.||||||||||||||||||:|||||||||||||||||:|.:|||:|.:|.|||||||||||||
Zfish   199 RVADQRSMRGNVAVFKCLIPSAVQEYVSVVSWEKDTVSIVPGNRFFLTSYGALYISDVQKEDALS 263

Human   195 TYRCITKHKYSGETRQSNGARLSVTGLARAADPLCLPDPAESIPTILDGFHSQEVWAGHTVELPC 259
            ||||||||||||||||||||||||.            ||.||.|:::|.|.|.||..|.::||||
Zfish   264 TYRCITKHKYSGETRQSNGARLSVL------------DPTESTPSVMDSFQSGEVQVGRSIELPC 316

Human   260 TASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVI 324
            .|||||.|.|||||||||||||||||:|:|||||||||.||||.|||||||:|||.|.||.|.||
Zfish   317 IASGYPNPTIRWLKDGRPLPADSRWTRRLTGLTISDLRLEDSGNYICEVTNSFGSKEVTGHLNVI 381

Human   325 DPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQ 389
            :||.|||:||.|||||.||||||||:.|||.||:.|:||||.::||:..||:|..||||.||:||
Zfish   382 EPLRVTLSPKNLKTGISSTVILSCAVQGSPHFTVSWFRNTEPIVPDQHFSIQGAHNETLFITAAQ 446

Human   390 KSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 454
            |.||||||||||||.||||||:||.||||||||||||||:||.|||.||||||||||||||:||.
Zfish   447 KRHSGAYQCFATRKGQTAQDFSIILLEDGTPRIVSSFSERVVAPGEPFSLMCAAKGAPPPTITWT 511

Human   455 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 519
            |||||:.||.:||.:|||:|||:|:||:|||.|||||||||||.|||..||||||||||||||||
Zfish   512 LDDEPVARDSAHRASQYTLSDGSTVSHVNVTNPQIRDGGVYRCAARNSAGSAEYQARINVRGPPS 576

Human   520 IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 584
            |||||||||||||:|.||||||||||||||||||.:||||||||||:|||||||:|||||||||.
Zfish   577 IRAMRNITAVAGRNTFINCRVIGYPYYSIKWYKDGMLLPDNHRQVVYENGTLKLSDVQKGMDEGA 641

Human   585 YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI 649
            |||||||||||||||:|:|.||||||||||:|||.|||:|:||.|||||||||||||||||||.|
Zfish   642 YLCSVLIQPQLSISQTVYVTVKVPPLIQPFDFPPTSIGKLMYIACVVSSGDMPIRITWRKDGQEI 706

Human   650 ISG-SGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDG 713
            :|| :|||||:||||||||||.|||||||||||||||.|||||.||||||.|||||.||||||||
Zfish   707 VSGTAGVTIETKEFMSSLQISKVSLKHNGNYTCIASNDAATVSSERQLIVTVPPRFRVQPNNQDG 771

Human   714 IYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYL 778
            ||||:.||||||:|||||||:||||||.||||||||||||||||||.|.|||||||||||.||||
Zfish   772 IYGKSEVLNCSVEGYPPPKVVWKHAKGIGNPQQYHPVPLTGRIQILSNGSLLIRHVLEEDRGYYL 836

Human   779 CQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 843
            ||||||||:||||||.||||||||||||||||:||||..||||||||||.|||||||:|||||||
Zfish   837 CQASNGVGSDISKSMMLTVKIPAMITSHPNTTMAIKGQNKELNCTARGEYPIIIRWERGDTVIDP 901

Human   844 DRVMRYAIATKDN--GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE 906
            ||..||:|.|..|  .|||:||||||||:|||||||||||||||||.||||||||||||||||||
Zfish   902 DRNPRYSITTSPNEKSDEVISTLKLKPAERGDSVFFSCHAINSYGEGRGLIQLTVQEPPDPPELE 966

Human   907 IREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYS 971
            :||||.||||||||||||||||||.:|||||||||.|:.|.:||.||||.||||||:||||||||
Zfish   967 VREVKDRSMNLRWTQRFDGNSIITSYDIEYKNKSDPWELKHATRKISPTNNQANIVELHPASVYS 1031

Human   972 IRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQI 1036
            |||||:||||||:.|||||||||||.||||||:|.|||:|||||:||||||||||||||||||||
Zfish  1032 IRMYSYNKIGRSQASKELTISTEEAPPDGPPMEVILQPMTSQSIRVTWKAPKKELQNGVIRGYQI 1096

Human  1037 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDV 1101
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1097 GYRENGPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDV 1161

Human  1102 PSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDG-------------EWGE 1153
            |||||:||||:::|||.|||:||||||.|||||||||||:|||||.||             :|||
Zfish  1162 PSQPPQNVRAITVTSDEAVITWSEPPRMTLNGVLKGYRVVFWSLYPDGGGCCGGQTLGLNQKWGE 1226

Human  1154 MQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASS 1218
            |||||||||:|||:|:||||||||||||||||||||||:||||||:||.||||||||||||||||
Zfish  1227 MQNITTTREQVELKGLEKFTNYSVQVLAYTQAGDGVRSNVLYIQTREDHPGPPAGIKAVPSSASS 1291

Human  1219 VVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSA 1283
            ||||||||.||||:||||||:|||||||||||||||.:||.|.|||.||.||||||:|.||||:|
Zfish  1292 VVVSWLPPVKPNGIIRKYTIYCSSPGSGQPAPSEYEANPELLIYRITHLTRGQQYLIWAAAVTTA 1356

Human  1284 GRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSM 1348
            ||||.|||||:||||||||||:||||||||||||:|||||:|||:|.|.:||||||||:||||:.
Zfish  1357 GRGNISEKVTVEPAGKAPAKILSFGGTVTTPWMKEVRLPCSSVGEPTPTIKWTKDSEDTAIPVTQ 1421

Human  1349 DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITL 1413
            ||||.|.:||||:||:||||||||||||||||.|||||||||||||||||||||||.||.|||||
Zfish  1422 DGHRNILSNGTLVLRSVKAEDSGYYTCTATNTLGFDTIIVNLLVQVPPDQPRLTVSTTSTSSITL 1486

Human  1414 TWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRI 1478
            .||||||||||||||||||||||:||||||||||||||||||:|:||||||||||||||||:|||
Zfish  1487 AWIPGDNGGSSIRGFVLQYSVDNTEEWKDVFISSSERSFKLDNLRCGTWYKVKLAAKNSVGAGRI 1551

Human  1479 SEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRAN 1543
            |||||||||||||.|:|||.|||||||||||:|||||.:|||||||::||:|||||||||.:|.|
Zfish  1552 SEIIEAKTHGREPQFNKDQPLFTHINSTHARMNLQGWTSGGCPITAVLLEFRPKGTWAWQSVRTN 1616

Human  1544 SSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIG 1608
            :|.::||.||||||||||:|:|||||||||:::||||||||||||||||||:||||||||||:||
Zfish  1617 ASADIFLAELREATWYELKMKACNSAGCGNQSSQFATLDYDGSTIPPIKSARGEGDDVKKLFSIG 1681

Human  1609 CPVILATLGVALLFIVRKKRKEKRLKRLRDAKSLAEMLI-SKNNRSFDTPVKGPPQGPRLHIDIP 1672
            |||||.|||:|||||:||||||||||||||||||||||| |||||||||||||||||||||||||
Zfish  1682 CPVILVTLGMALLFIIRKKRKEKRLKRLRDAKSLAEMLISSKNNRSFDTPVKGPPQGPRLHIDIP 1746

Human  1673 RVQLLIEDKEGIKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPG 1737
            ||||||||||||||:|:|||||||||.||||:|||||||||||:|||.|||:|||||||||||||
Zfish  1747 RVQLLIEDKEGIKQIGEDKATIPVTDTEFSQSVNPQSFCTGVSVHHPALIQNTGPLIDMSDIRPG 1811

Human  1738 TNPVSRKNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQD 1802
            |||||||:|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
Zfish  1812 TNPVSRKSVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGITVTESDSYSASLSQD 1876

Human  1803 TDKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSM 1867
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||:|||||
Zfish  1877 TDKGRNSMVSTESASSTYEELARAYEHAKLEEHLQHAKFEITECFISDSSSDQMTTGTNDNADSM 1941

Human  1868 TSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRK-ADGREP 1931
            |||||||||||||||||||||||.|||||||||||||||||:|||||||.|::.|||| |:..:|
Zfish  1942 TSMSTPSEPGICRFTASPPKPQDYDRGKNVAVPIPHRANKSEYCNLPLYMKTDPFFRKQAELHDP 2006

Human  1932 CPVVPPREASIRNL-ARTYHTQARHLTLDP--------------------ASKSLGLPHPGAPAA 1975
            ||||||||||||:| ||.||||.||:||||                    ||.:.|.|..||..:
Zfish  2007 CPVVPPREASIRSLAARAYHTQGRHMTLDPSKQQALTLGHGGLSSLTSSGASGTSGPPSSGAAGS 2071

Human  1976 AS----TATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGP---HTKMG 2033
            :|    |||||||||.||:    |:..:..|:.|   .|..|...|.||   ...||   .:|:|
Zfish  2072 SSISSGTATLPQRTLTMPS----TSSTSSAPSGA---VAAGAGASASST---GGSGPTPGSSKVG 2126

Human  2034 GSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV 2065
            ||||||||.|:||:||.|||.|||||||||||
Zfish  2127 GSRDSLLESSSSGLGRLQKQNAGAYSKSYTLV 2158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653	67/75 (89%)
		IGc2	43..110	CDD:197706	59/66 (89%)
		Ig	125..218	CDD:299845	83/92 (90%)
		IG_like	137..209	CDD:214653	63/71 (89%)
		I-set	245..323	CDD:254352	59/77 (77%)
		IGc2	252..313	CDD:197706	49/60 (82%)
		IGc2	340..401	CDD:197706	41/60 (68%)
		I-set	420..514	CDD:254352	74/93 (80%)
		Ig	420..510	CDD:299845	70/89 (79%)
		IGc2	531..589	CDD:197706	50/57 (88%)
		IG_like	619..698	CDD:214653	67/79 (85%)
		Ig	627..693	CDD:143165	58/66 (88%)
		I-set	702..797	CDD:254352	83/94 (88%)
		Ig7_DSCAM	719..797	CDD:143211	68/77 (88%)
		I-set	803..896	CDD:254352	77/94 (82%)
		Ig	815..903	CDD:299845	73/89 (82%)
		FN3	899..993	CDD:238020	78/93 (84%)
		FN3	1000..1097	CDD:238020	91/96 (95%)
		fn3	1105..1191	CDD:278470	72/98 (73%)
		FN3	1203..1294	CDD:238020	77/90 (86%)
		IGc2	1318..1382	CDD:197706	49/63 (78%)
		FN3	1396..1486	CDD:238020	82/89 (92%)
		FN3	1500..1572	CDD:238020	55/71 (77%)
dscaml1	XP_005157551.1	IG_like	112..184	CDD:214653	64/71 (90%)
		Ig	112..183	CDD:143165	63/70 (90%)
		Ig	194..287	CDD:299845	83/92 (90%)
		I-set	302..380	CDD:254352	59/77 (77%)
		IGc2	309..370	CDD:197706	49/60 (82%)
		IGc2	399..458	CDD:197706	40/58 (69%)
		I-set	477..571	CDD:254352	74/93 (80%)
		Ig	477..567	CDD:299845	70/89 (79%)
		IG_like	581..662	CDD:214653	71/80 (89%)
		IGc2	588..646	CDD:197706	50/57 (88%)
		Ig	684..751	CDD:143165	58/66 (88%)
		IG_like	686..756	CDD:214653	61/69 (88%)
		I-set	760..855	CDD:254352	83/94 (88%)
		Ig7_DSCAM	778..855	CDD:143211	68/76 (89%)
		IG_like	865..956	CDD:214653	73/90 (81%)
		Ig	873..963	CDD:299845	73/89 (82%)
		FN3	959..1053	CDD:238020	78/93 (84%)
		FN3	1060..1157	CDD:238020	91/96 (95%)
		FN3	1165..1271	CDD:238020	78/105 (74%)
		FN3	1276..1367	CDD:238020	77/90 (86%)
		IGc2	1392..1455	CDD:197706	49/62 (79%)
		FN3	1486..1559	CDD:238020	67/72 (93%)
		FN3	1573..1649	CDD:238020	58/75 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194333243
Domainoid	1	1.000	952	1.000	Domainoid score	I497
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H79549
Inparanoid	1	1.050	2646	1.000	Inparanoid score	I220
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	1	1.000	-	-		FOG0003568
OrthoInspector	1	1.000	-	-		oto42537
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810