DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fynb and Src42A

DIOPT Version :9

Sequence 1:	NP_001025140.1	Gene:	fynb / 574422	ZFINID:	ZDB-GENE-050706-89	Length:	544	Species:	Danio rerio
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	238/433 - (54%)
Similarity:	306/433 - (70%)	Gaps:	33/433 - (7%)

- Green bases have known domain annotations that are detailed below.

Zfish   111 RKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGN 175
            :||:..::...|.|::.:.:|                        |||.|:.|.:||::||...|
  Fly  1189 KKGKSRRLSEFTRGEFLNEKS------------------------WYFRKIKRIEAEKKLLLPEN 1229

Zfish   176 PRGTFLIRESETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDSGGYYITTRAQFETLQQLVQHYTE 240
            ..|.||||:||:....:|||:||     ||.||||:||:||.||::|..|..|.|||:||:||::
  Fly  1230 EHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSK 1289

Zfish   241 RAAGLCCRLVVPCHKGMPRLTD-LSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVA 304
            .:.|||..|..||.:....:|: ||.:|:|.|||.|.||:.:::||:||||:||.|.||..|.||
  Fly  1290 DSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVA 1354

Zfish   305 IKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMGKGSLLDFLK--DGEG 366
            |||||.|||.|:.||.||||||||||.||:|||||.: ||||||:||.|..||||::|:  .|:|
  Fly  1355 IKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKG 1419

Zfish   367 RALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQ 431
            |:||:..|:|||||:|.||||:|..|||||||.:.|:||||..:.|||||||||||:::||.||.
  Fly  1420 RSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARV 1484

Zfish   432 GAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQ 496
            ||:|||||||||||.|.||:|||||||||||||||||.||:|||||.|.|||.|||.||||..|.
  Fly  1485 GARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPP 1549

Zfish   497 DCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQ 539
            :|...|:|:|::||.||...|||||.||..|||::|:.:..|:
  Fly  1550 NCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fynb	NP_001025140.1	SH3_Fyn_Yrk	92..147	CDD:212939	5/35 (14%)
		SH2_Src_Fyn_isoform_a_like	152..252	CDD:198281	48/99 (48%)
		PKc_like	268..541	CDD:304357	179/275 (65%)
		Pkinase_Tyr	278..527	CDD:285015	168/251 (67%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	48/95 (51%)
		PTKc_Frk_like	1319..1587	CDD:270653	178/267 (67%)
		Pkinase_Tyr	1328..1580	CDD:285015	168/251 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930