Protein Alignment PTGS1 and Irc

DIOPT Version :9

• Sequence 1: NP_000953.2
• Gene: PTGS1 / 5742
• HGNCID: 9604
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001262653.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 121/604 - (20%)
• Similarity: 212/604 - (35%)
• Gaps: 159/604 - (26%)

Human    60 RTGY------SGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVN------ATFIREMLM 112
            |.|:      ||...|:|..|:..:....|.    |..::..:.|....|      |.|:...|.
  Fly   164 RNGFYQMFPNSGRRETVPAAWSISKELYEPD----HIQISKQQTFESNSNLALPQWAQFVEHDLS 224

Human   113 RLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLA 177
            :.|....||   ..|....:.|.|:.:...:          .|...|......||..:|......
  Fly   225 KPVSQSMSN---GAPIECCSRDQINLQPRHH----------HPACAPILYQPGGKYDVPSCLNYV 276

Human   178 RRFLLRRKFIPDPQGTNLMFAFFAQHF--THQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 240
            |..|                |....:|  ..|..:.:|.:            ||..:||.....:
  Fly   277 RSAL----------------AVADCNFGGAEQLNQATGSL------------DLSQLYGFTAAAE 313

Human   241 YQLRLFKDGKLKYQ---VLDGEMYPPSVE-EAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYA 301
            .:||:.:.|.|:..   ..|..:.|.:.: |.|....... |...:..|.|.......|..:|..
  Fly   314 RKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFCARAT-IGDGTCFAAGDSRVNSSPFSILIY 377

Human   302 TLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF---DPE 363
            |:::|.||:|...||..:|.|.||:|||..:.:.:....::||||::.::.|..:..:.   .|.
  Fly   378 TIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPN 442

Human   364 LLFGVQFQY-----RNRIAMEFNHLYHWHPLMPDSFKVGSQ---------------------EYS 402
            ....|..::     |...:|..|.|.:   |..|:...|::                     |..
  Fly   443 RALEVSNEFAVAAIRFYFSMLPNELLN---LTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEI 504

Human   403 YEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGG--RNMDHHILH---VAVDVIRESREMRLQPF 462
            |:..|..||..::..:|:|::..:.::.....||  .:.|....|   :|.| |:..|:..|.|:
  Fly   505 YKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFD-IQRGRDHGLLPY 568

Human   463 NEYRKRFGM-KPYTS---FQELVGEKEMAAELEELY---GDIDALEFYPGLLLEKCHPNSIFGES 520
            ..|.:...: :|..|   |:..: ..::..:|:.:|   .|:|       |::.....|.:.|
  Fly   569 YRYLESCVLSRPVESWKDFEHFI-PSDVLDKLKTIYASWADVD-------LIVGGISENPVHG-- 623

Human   521 MIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLK------------------KLV 567
              .||..||.       |.|.::           .:::|....|                  ||:
  Fly   624 --SIGPTFSC-------IISEQF-----------VHVLKQNQQKAVQKHTELVEQYRHFNGTKLL 668

Human   568 CLNT--KTCPYVSFRVPDA 584
            |||:  ...|...|::|.|
  Fly   669 CLNSGLSAVPQNIFQLPSA 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTGS1	NP_000953.2	EGF_CA	32..69	CDD:238011	4/14 (29%)
		prostaglandin_endoperoxide_synthase	89..575	CDD:188648	109/558 (20%)
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	116/587 (20%)
		An_peroxidase_like	290..637	CDD:265428	81/382 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810