DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCYL1 and CEX1

DIOPT Version :10

Sequence 1:NP_065731.3 Gene:SCYL1 / 57410 HGNCID:14372 Length:808 Species:Homo sapiens
Sequence 2:NP_014755.1 Gene:CEX1 / 854279 SGDID:S000005638 Length:761 Species:Saccharomyces cerevisiae


Alignment Length:840 Identity:177/840 - (21%)
Similarity:305/840 - (36%) Gaps:216/840 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    29 WALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETE-KCLHVV 92
            |....|.:||...||::|  ..|...|.::.:..|..|. |.|:.|.:...::..::: :...:|
Yeast    30 WQCFDGTRKADSLPVTVF--KAKRSPENESLILNAVHKS-KILKIPGLCTVLETFDSDPQSTFIV 91

Human    93 TEAVTP-----LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRA 152
            ||.|.|     ||...:        .:..:..|:.|::..|.||.|   .:...:...:||::..
Yeast    92 TERVVPFPWDNLGSLSQ--------NKFGVELGISQLLATLGFLKN---FVLGTLSKDSVFINIK 145

Human   153 GEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVV------REKWSADMWRLGCL 211
            |||.|.||:...|.:|            |..::....|.|...::      .:..:.|...||.|
Yeast   146 GEWVLFGLELCSSKEG------------LSAFEFASRARSYYNIIGSQLPCEDPNTIDSMGLGLL 198

Human   212 IWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETN 276
            |           .:|..|..:||..:.: ..::........|..:.|:|...   :.||..:...
Yeast   199 I-----------KSLMAPSCLPKDWIVN-VNMISDGKITIENFRKRLENTET---WRSNPLINFY 248

Human   277 LFLEEIQIKEP--------------AEKQKFFQELSKSLDAFPEDFCRHKVLPQ------LLTAF 321
            ..|.|:.||:|              .|.::.|:.|:..:   .|:|    ::|:      ||...
Yeast   249 QELRELHIKDPQGKLVVMSNLENLYLESREIFRNLTPGM---IENF----IIPELCEIIKLLMTQ 306

Human   322 EFGNAGAVV---------LTPLFKVGKFLSAEEYQQKIIPV-----VVKMFSSTDRAMRIRLLQQ 372
            ...:|.:.:         |.|...:...|::|   ....||     :.:.|...||.:|..||..
Yeast   307 SISSAASPIGMNFNASHKLVPFLAIVLDLTSE---TNTFPVGFNDLITQSFKLPDRQVRFLLLIY 368

Human   373 MEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQA 437
            :.:.|..|.:..::::|:||.:.|..|::..:|.||:|::..:...|.|..||.||::..|:.|.
Yeast   369 LPKLIGPLSKSEISSRIYPHFIQGLTDSDATLRLQTLKTIPCIVSCLTERQLNNELLRFLAKTQV 433

Human   438 KDEQGPIRCNTTVCLGKIGSYLSAS--TRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSM 500
             |....||..|.:.:.||.:.||.|  .|..:|.:||:::.:||....|:|.:.|...:..|:.:
Yeast   434 -DSDVEIRTWTVIIISKISTILSTSVGNRSNILATAFTKSLKDPQVKPRLAALYGLEKSIELFDV 497

Human   501 NDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSE-----DPTQLEEVEKDV----HA 556
            |..|.|||.|:....:|....||.:|......:|.|||..::     |.|...|..||:    :.
Yeast   498 NTIANKILTVIAPGLLDKSPIVRGRAKILFEEYLEKLEKEAQLIQTNDSTADSEDVKDIDFENYG 562

Human   557 ASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTT 621
            .....|....           :.|.::.:.:      ...|.|...||..:              
Yeast   563 CDEEDMNKED-----------NLLAAQFLNN------LRLNSPSATTPSNI-------------- 596

Human   622 SGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQVSN-----S 681
                  .|.:.|:|:|.|   .|||             |:..|.:.|.|......:.:|     |
Yeast   597 ------TESEIDSAQDGS---GWDD-------------LSDTDGFITNGTTESFDETTNPVTTAS 639

Human   682 DHKSSKSPESDWSSWEAE---GSWEQGWQEPS---SQEPPPDGTRLASEYNWGGPES-------- 732
            ..|....|.....||..|   ..|.|....||   .:...|..:.||...   .|.|        
Yeast   640 TPKLFGKPIKINKSWNDELNDDGWIQDESGPSKVPQKHTRPQNSTLAKSI---APSSRLSIKKKK 701

Human   733 ------------------------SDKGDPFATLSARPSTQPRPDSWGED--------NW 760
                                    :.:..|.:::....:.:...|.|.:|        ||
Yeast   702 TTILAPRNIASNSTVTTKSSLSNKTARSKPISSIRGSVTKKGNVDGWDDDGDSDSWDTNW 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCYL1NP_065731.3 PK_SCY1_like 20..296 CDD:270913 61/292 (21%)
HEAT repeat 314..336 CDD:293787 6/36 (17%)
HEAT 1 350..388 10/42 (24%)
HEAT repeat 351..372 CDD:293787 8/25 (32%)
HEAT repeat 384..417 CDD:293787 9/32 (28%)
HEAT 2 389..427 13/37 (35%)
HEAT repeat 427..458 CDD:293787 10/30 (33%)
HEAT repeat 467..499 CDD:293787 9/31 (29%)
HEAT repeat 505..530 CDD:293787 8/24 (33%)
HEAT 3 507..545 12/42 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..566 6/34 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..646 10/58 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..808 26/154 (17%)
Interaction with COPB1. /evidence=ECO:0000250 793..808
CEX1NP_014755.1 Protein Kinases, catalytic domain 29..257 CDD:473864 56/267 (21%)
HEAT repeat 342..371 CDD:293787 8/28 (29%)
YCG1 356..>491 CDD:227543 42/135 (31%)
HEAT repeat 385..413 CDD:293787 9/27 (33%)
HEAT repeat 423..453 CDD:293787 10/30 (33%)
HEAT repeat 462..490 CDD:293787 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

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