DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCYL1 and scyl1

DIOPT Version :10

Sequence 1:NP_065731.3 Gene:SCYL1 / 57410 HGNCID:14372 Length:808 Species:Homo sapiens
Sequence 2:XP_001332508.1 Gene:scyl1 / 793792 ZFINID:ZDB-GENE-030131-8915 Length:855 Species:Danio rerio


Alignment Length:873 Identity:552/873 - (63%)
Similarity:643/873 - (73%) Gaps:83/873 - (9%)


- Green bases have known domain annotations that are detailed below.


Human     1 MW-FFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAA 64
            || ||||||::||.:||:||..|..  |.|.|.||::|:||.|||:|||:|..|.|||||:||||
Zfish     1 MWSFFARDPIKDFNYELLPENQEKS--GIWTLSRGKRKSTGEPVSVFVYEVSQGTEEQTQLAKAA 63

Human    65 FKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALS 129
            |||.|||||||||:|:|||||||.|::|||.||||..:||.:.|.||..:||:||||||||||||
Zfish    64 FKRTKTLRHPNILSYVDGLETEKSLYIVTEPVTPLAAHLKLQAEKGGASDLEVSWGLHQIVKALS 128

Human   130 FLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNG-GGPPRKGI-PELEQYDPPELADS 192
            ||||||.|.|||:.|.||||||||||||||||::.|.||:. ..||.|.| |:||:|||||..:|
Zfish   129 FLVNDCHLNHNNLGMWAVFVDRAGEWKLGGLDHVTSEQGDSITLPPPKVINPDLERYDPPESPNS 193

Human   193 SGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARF 257
            .|    |||:.|:|||||||||||||.||||::||:.|||||.||||||||||||||:|||||||
Zfish   194 GG----EKWTGDVWRLGCLIWEVFNGSLPRASSLRSLGKIPKQLVPHYCELVGANPKIRPNPARF 254

Human   258 LQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFE 322
            |.|||:|||||:|.|||:.|||||||||||||||:|||:||::||:||||||:||||||||||||
Zfish   255 LLNCRSPGGFMNNSFVESCLFLEEIQIKEPAEKQQFFQDLSENLDSFPEDFCKHKVLPQLLTAFE 319

Human   323 FGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNT 387
            |||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||:|..||:
Zfish   320 FGNAGAVVLTPLFKVGKYLSAEEYQQKIIPVIVKMFSSTDRAMRIRLLQQMEQFIQYLNEAAVNS 384

Human   388 QIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCL 452
            ||||||||||.|||||||||||||||||||||||.|||.|||:|||||||:|:||||||||||||
Zfish   385 QIFPHVVHGFTDTNPAIREQTVKSMLLLAPKLNETNLNQELMRHFARLQARDDQGPIRCNTTVCL 449

Human   453 GKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVD 517
            |||..||:|..|.|||.|||||||:|||..||.||||||||||..||:.:.|.:|||.||.||||
Zfish   450 GKIAPYLNAGMRQRVLISAFSRATKDPFPASRAAGVLGFAATHQYYSVAESANRILPTLCTLTVD 514

Human   518 PEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTS 582
            |:|:|||||||||:|||||||:|||||::|.|:||||.||..  .||:||:||||||||||||||
Zfish   515 PDKNVRDQAFKAIKSFLSKLETVSEDPSKLTEIEKDVTAAGQ--TGGSAATWAGWAVTGVSSLTS 577

Human   583 KLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTA------ 641
            ||||:.|..:       :.|:.|...:|.|........|:...|..:....:...|.|:      
Zfish   578 KLIRNAPAGS-------EAPSAENTSSPQPAAGSVNTNTADKAEEMKTQTSSGIKSETSNEETGD 635

Human   642 ---DRWDDEDWGSLEQEAESVLAQQDDW-STGGQVSRASQVSNSDHKSS---KSPESDWSS-WEA 698
               ||||:||||||| :.|.|....||| |....||...:.||...|||   |...||||| |:|
Zfish   636 TDGDRWDEEDWGSLE-DPEKVQTDPDDWQSNWSSVSSTQKKSNVGRKSSEAVKKQSSDWSSGWDA 699

Human   699 EGSW---------------EQGWQEPSSQE--------PPP---------------DGTRLASEY 725
            :.||               ::||.....::        |.|               ||.||||:|
Zfish   700 DDSWSNEKDADGQGQSSPADEGWGNDWDEDGTLAESFAPTPRIKSSAATKSASSAQDGVRLASDY 764

Human   726 NWGGPE-SSDKGDPFATLSARPSTQPRPDSWG---------EDNWEGLETDSRQVKAELARKKRE 780
            ||.|.| .|...|..:::|.|.:|  :.|.|.         |||||.|:.:....|||||:||||
Zfish   765 NWDGMEGKSTTSDLLSSVSQRSAT--KSDGWDADSAGDWGTEDNWESLDGEQGLSKAELAKKKRE 827

Human   781 ERRREMEAKRAERKVAKGPMKLGARKLD 808
            |||:|:||||||||.||||:||||||||
Zfish   828 ERRKELEAKRAERKAAKGPLKLGARKLD 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCYL1NP_065731.3 PK_SCY1_like 20..296 CDD:270913 196/277 (71%)
HEAT repeat 314..336 CDD:293787 21/21 (100%)
HEAT 1 350..388 33/37 (89%)
HEAT repeat 351..372 CDD:293787 19/20 (95%)
HEAT repeat 384..417 CDD:293787 29/32 (91%)
HEAT 2 389..427 35/37 (95%)
HEAT repeat 427..458 CDD:293787 26/30 (87%)
HEAT repeat 467..499 CDD:293787 24/31 (77%)
HEAT repeat 505..530 CDD:293787 18/24 (75%)
HEAT 3 507..545 31/37 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..566 15/25 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..646 12/67 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..808 81/202 (40%)
Interaction with COPB1. /evidence=ECO:0000250 793..808 12/14 (86%)
scyl1XP_001332508.1 Protein Kinases, catalytic domain 28..293 CDD:473864 194/268 (72%)
HEAT repeat 311..333 CDD:293787 21/21 (100%)
HEAT repeat 348..369 CDD:293787 19/20 (95%)
HEAT repeat 381..414 CDD:293787 29/32 (91%)
HEAT repeat 424..455 CDD:293787 26/30 (87%)
HEAT repeat 464..490 CDD:293787 20/25 (80%)
HEAT repeat 501..530 CDD:293787 21/28 (75%)
HEAT 504..534 CDD:460773 24/29 (83%)
MSCRAMM_ClfA <535..820 CDD:468110 108/296 (36%)

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