Protein Alignment SCYL1 and Scyl1

DIOPT Version :10

• Sequence 1: NP_065731.3
• Gene: SCYL1 / 57410
• HGNCID: 14372
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_076401.1
• Gene: Scyl1 / 78891
• MGIID: 1931787
• Length: 806
• Species: Mus musculus
• Alignment Length: 810
• Identity: 735/810 - (90%)
• Similarity: 756/810 - (93%)
• Gaps: 6/810 - (0%)

Human     1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAF 65
            ||||||||||||||||.|||||||.||||.|||||||||||.|||||||||||||||||||||||
Mouse     1 MWFFARDPVRDFPFELSPEPPEGGPPGPWILHRGRKKATGSAVSIFVYDVKPGAEEQTQVAKAAF 65

Human    66 KRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSF 130
            ||.||||||||||||||||||||||:|||||||||.|||||.|||||||.|:|||||||||||||
Mouse    66 KRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTYLKARAEAGGLKEQELSWGLHQIVKALSF 130

Human   131 LVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGR 195
            |||||:||||||||||||||||||||||||||||||||||||||.||||||||||||||||||.|
Mouse   131 LVNDCNLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPSKGIPELEQYDPPELADSSSR 195

Human   196 VVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQN 260
            .||||||||||||||||||||||.|||||||||||||||:||.||||||||||||||||||||||
Mouse   196 AVREKWSADMWRLGCLIWEVFNGSLPRAAALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQN 260

Human   261 CRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGN 325
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Mouse   261 CRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGN 325

Human   326 AGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIF 390
            ||||||||||||||.|.|||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   326 AGAVVLTPLFKVGKSLRAEEYQEKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIF 390

Human   391 PHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKI 455
            |||.|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
Mouse   391 PHVTHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDDQGPIRCNTTVCLGKI 455

Human   456 GSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEK 520
            |||||||||||||||||||||:|||||||||||||||||||||||:|||.|||||||||||||||
Mouse   456 GSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKILPVLCGLTVDPEK 520

Human   521 SVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLI 585
            ||||||||.||||||||||||||||||.|||||||||||||.|||||||||||||||||||||||
Mouse   521 SVRDQAFKTIRSFLSKLESVSEDPTQLAEVEKDVHAASSPGTGGAAASWAGWAVTGVSSLTSKLI 585

Human   586 RSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWG 650
            |:|||..|::|.:||||.|||.|||||....|.|.|||||||| |||||||||:|||||||||||
Mouse   586 RAHPTPVPSDTTVPQRPVPEGNPAPAPALAQAIPATSGHWETQ-EDKDTAEDSATADRWDDEDWG 649

Human   651 SLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPP 715
            |||||||||||||||||..||.|||.|:::.||||.   ||.|||||.||||:||||||||.|||
Mouse   650 SLEQEAESVLAQQDDWSAKGQGSRAGQINHPDHKSL---ESHWSSWEVEGSWDQGWQEPSSVEPP 711

Human   716 PDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPR--PDSWGEDNWEGLETDSRQVKAELARKK 778
            |:||||||||||||.|.||||||||.||.|||.|||  |||||||||||||.:||||||||||||
Mouse   712 PEGTRLASEYNWGGAEPSDKGDPFAALSVRPSAQPRPDPDSWGEDNWEGLEAESRQVKAELARKK 776

Human   779 REERRREMEAKRAERKVAKGPMKLGARKLD 808
            ||||||||||||||:|..||||||||||||
Mouse   777 REERRREMEAKRAEKKTTKGPMKLGARKLD 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCYL1	NP_065731.3	PK_SCY1_like	20..296	CDD:270913	259/275 (94%)
		HEAT repeat	314..336	CDD:293787	21/21 (100%)
		HEAT 1	350..388		37/37 (100%)
		HEAT repeat	351..372	CDD:293787	20/20 (100%)
		HEAT repeat	384..417	CDD:293787	31/32 (97%)
		HEAT 2	389..427		36/37 (97%)
		HEAT repeat	427..458	CDD:293787	29/30 (97%)
		HEAT repeat	467..499	CDD:293787	30/31 (97%)
		HEAT repeat	505..530	CDD:293787	23/24 (96%)
		HEAT 3	507..545		36/37 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..566		23/25 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..646		41/58 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..808		122/151 (81%)
		Interaction with COPB1. /evidence=ECO:0000250	793..808		11/14 (79%)
Scyl1	NP_076401.1	PK_SCY1_like	29..296	CDD:270913	251/266 (94%)
		HEAT repeat	314..336	CDD:293787	21/21 (100%)
		HEAT 1	350..388		37/37 (100%)
		HEAT repeat	351..372	CDD:293787	20/20 (100%)
		HEAT repeat	384..417	CDD:293787	31/32 (97%)
		HEAT 2	389..427		36/37 (97%)
		HEAT repeat	427..458	CDD:293787	29/30 (97%)
		HEAT repeat	467..499	CDD:293787	30/31 (97%)
		HEAT 3	507..545		36/37 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..642		39/56 (70%)
		PHA03169	604..>762	CDD:223003	128/161 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..806		116/145 (80%)
		Interaction with COPB1. /evidence=ECO:0000269|PubMed:18556652	791..806		11/14 (79%)