Protein Alignment SCYL1 and scyl1

DIOPT Version :10

• Sequence 1: NP_065731.3
• Gene: SCYL1 / 57410
• HGNCID: 14372
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_001016149.1
• Gene: scyl1 / 548903
• XenbaseID: XB-GENE-5843537
• Length: 827
• Species: Xenopus tropicalis
• Alignment Length: 846
• Identity: 555/846 - (65%)
• Similarity: 651/846 - (76%)
• Gaps: 57/846 - (6%)

Human     1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAF 65
            |||::|||.||||:::..|..|  ||..|.:.:|:||..|..||:|.|:::||||||||.||.|.
 Frog     1 MWFWSRDPARDFPYDVTGEREE--LPAGWGVQKGKKKTGGDAVSVFTYEIRPGAEEQTQAAKTAL 63

Human    66 KRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSF 130
            ||.|||:|||||:|:|||||:|||::|||.|||||.|:|.|.::||:.|||||||||||||||||
 Frog    64 KRIKTLKHPNILSYVDGLETDKCLYIVTEPVTPLGTYVKLRTDSGGVSELEISWGLHQIVKALSF 128

Human   131 LVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGR 195
            ||||.:||||||||:|||||||||||||||||||:| |.....|.||| |:|:|:|||..|.| :
 Frog   129 LVNDGNLIHNNVCMSAVFVDRAGEWKLGGLDYMYTA-GAEDTAPLKGI-EMEKYNPPEKTDRS-K 190

Human   196 VVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQN 260
            ..:||||||||.|||||||||||||||..|||:.|||||:|||||||||||||||||||||||||
 Frog   191 TSKEKWSADMWCLGCLIWEVFNGPLPRPTALRSLGKIPKSLVPHYCELVGANPKVRPNPARFLQN 255

Human   261 CRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGN 325
            ||:||||..|.||||||||||||||:|||||.||::||::||:|||||||||:|||||||||||:
 Frog   256 CRSPGGFFCNSFVETNLFLEEIQIKDPAEKQTFFEQLSENLDSFPEDFCRHKILPQLLTAFEFGS 320

Human   326 AGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIF 390
            ||||||.||||:||||:|:||||||||||||||||||||||||||||||.|||||:|||||.|||
 Frog   321 AGAVVLPPLFKIGKFLNADEYQQKIIPVVVKMFSSTDRAMRIRLLQQMENFIQYLNEPTVNAQIF 385

Human   391 PHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKI 455
            |||||||:|||||||||||||||||||||||.|||:|||||||||||:|:|||||||||||||||
 Frog   386 PHVVHGFMDTNPAIREQTVKSMLLLAPKLNENNLNMELMKHFARLQARDDQGPIRCNTTVCLGKI 450

Human   456 GSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEK 520
            ..||:.:||.|||.|||||||:|||:|||.|||||||||||.||:.|||.|:||||||:||||||
 Frog   451 APYLNPATRQRVLISAFSRATKDPFSPSRAAGVLGFAATHNFYSLTDCAGKVLPVLCGVTVDPEK 515

Human   521 SVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAAS-SPGMGGAAASWAGWAVTGVSSLTSKL 584
            :||:||||||||||.|||:|||||:||.|:|||||.|| ||.:.|   .|||||||||||||||.
 Frog   516 NVREQAFKAIRSFLDKLETVSEDPSQLAELEKDVHTASVSPSVVG---GWAGWAVTGVSSLTSKF 577

Human   585 IR----------SHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSS 639
            ||          |...:||:..:...:|.    .||:.:..||..:|:......||:|...::|
 Frog   578 IRTGGGAQDAAASEGASAPSTASEASKPD----TAPSSSAPPAAASTAPTSYEPEEEKGAPDNS- 637

Human   640 TADRWDDEDWGSLEQEAESVLAQ--QDDWST----GGQVSRASQVSNSDHKSSK-SPESDWSSWE 697
             .|||||||||||| :||....|  .|||.|    |....:....|:|..|:.: ||..:.:|..
 Frog   638 -LDRWDDEDWGSLE-DAEQNRGQTENDDWDTDWGHGKTQEKTVDFSSSRSKTKQVSPPPNRTSAL 700

Human   698 AEGSWEQGWQEPSSQEPPP-----------DGTRLASEYNWGGPESSDK-GDPFATLSARPSTQP 750
            .:| |  ||.:.....||.           :|||.||:|||....||.: ||.||:|| .||:|.
 Frog   701 DDG-W--GWDDAFQTVPPSKEHTASKSQQLEGTRPASDYNWDTSGSSGRQGDFFASLS-EPSSQK 761

Human   751 RPD-------SW-GEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKL 807
            ..:       .| |:||||.:|.|....|||:||||||||::|:|||||||:.||||:|||.|||
 Frog   762 NDNRNSDSAGDWGGDDNWESVEADQGLSKAEMARKKREERQKEIEAKRAERRAAKGPLKLGVRKL 826

Human   808 D 808
            |
 Frog   827 D 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCYL1	NP_065731.3	PK_SCY1_like	20..296	CDD:270913	201/275 (73%)
		HEAT repeat	314..336	CDD:293787	19/21 (90%)
		HEAT 1	350..388		35/37 (95%)
		HEAT repeat	351..372	CDD:293787	20/20 (100%)
		HEAT repeat	384..417	CDD:293787	30/32 (94%)
		HEAT 2	389..427		35/37 (95%)
		HEAT repeat	427..458	CDD:293787	27/30 (90%)
		HEAT repeat	467..499	CDD:293787	26/31 (84%)
		HEAT repeat	505..530	CDD:293787	19/24 (79%)
		HEAT 3	507..545		31/37 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..566		18/26 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..646		16/58 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..808		73/176 (41%)
		Interaction with COPB1. /evidence=ECO:0000250	793..808		10/14 (71%)
scyl1	NP_001016149.1	Protein Kinases, catalytic domain	27..290	CDD:473864	197/265 (74%)
		HEAT repeat	271..297	CDD:293787	19/25 (76%)
		HEAT repeat	307..335	CDD:293787	23/27 (85%)
		HEAT repeat	344..370	CDD:293787	25/25 (100%)
		HEAT 1	345..383		35/37 (95%)
		HEAT repeat	381..410	CDD:293787	26/28 (93%)
		HEAT 2	384..422		35/37 (95%)
		HEAT repeat	422..453	CDD:293787	27/30 (90%)
		HEAT repeat	462..488	CDD:293787	21/25 (84%)
		HEAT repeat	499..525	CDD:293787	20/25 (80%)
		HEAT 3	502..540		31/37 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..827		100/251 (40%)