DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCYL1 and yata

DIOPT Version :10

Sequence 1:NP_065731.3 Gene:SCYL1 / 57410 HGNCID:14372 Length:808 Species:Homo sapiens
Sequence 2:NP_651722.1 Gene:yata / 43508 FlyBaseID:FBgn0260990 Length:873 Species:Drosophila melanogaster


Alignment Length:891 Identity:412/891 - (46%)
Similarity:534/891 - (59%) Gaps:102/891 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     1 MW-FFARDPVRDFPFELIPEPPEGGLP--GPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAK 62
            || ||:||..:|||:::  ..|.||..  ..|.||:.::|.|...||:||||::.|::.:.::||
  Fly     1 MWSFFSRDSSKDFPYDI--GEPVGGFDQYSIWTLHKAKRKTTLEEVSVFVYDIRSGSDTKCELAK 63

Human    63 AAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKA 127
            ||.||.||||||:||.|:|.|||:|.|:|.||||.|||.|..........|.|.::||:.||.:|
  Fly    64 AALKRLKTLRHPSILQYLDSLETDKMLYVATEAVDPLGTYFSKLGSDNVQKGLYLAWGIFQITRA 128

Human   128 LSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADS 192
            ||||.||.:|.||||...:|||:.:||||||.|:|:.:|.|| ..||.|....||.||.||..|.
  Fly   129 LSFLNNDGNLRHNNVSAWSVFVNASGEWKLGSLEYVSAADGN-PMPPAKIPVTLEVYDSPEKNDP 192

Human   193 SGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARF 257
            |......|.|.|||.||||:||.|||.|.:.:.|::...|||:|...|||||||:|..|||||..
  Fly   193 SKLKAATKCSVDMWGLGCLVWEAFNGVLKQRSNLKDIEHIPKSLQSLYCELVGASPSNRPNPADI 257

Human   258 LQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFE 322
            :..||.||||..|..|:|.|||||||||:.|||.:||..|:..||.||::.||||:||||:||:|
  Fly   258 ITRCRKPGGFFKNDLVDTLLFLEEIQIKDKAEKNRFFSGLTTHLDNFPDNVCRHKILPQLITAYE 322

Human   323 FGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNT 387
            :|:||:.||.|:||:||.|...|||::|:|.|||:|:||||..|.|||||::.||.:|....||.
  Fly   323 YGDAGSAVLAPMFKLGKLLDEVEYQKRIVPCVVKLFASTDRVTRSRLLQQLDLFIAHLQPQVVND 387

Human   388 QIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCL 452
            ||||.|.|||||||..||||||||::.||||||..|||||:::|||||||:|:||.||.||||||
  Fly   388 QIFPQVAHGFLDTNATIREQTVKSIIHLAPKLNYNNLNVEVLRHFARLQARDDQGGIRTNTTVCL 452

Human   453 GKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVD 517
            |||..:|....|.|||.|||.||.||||.|:||||||..|||...:.:::.|.::||.||.||||
  Fly   453 GKIAPHLHPQVRQRVLVSAFIRAMRDPFPPARVAGVLALAATQQYFLLSEVANRVLPSLCSLTVD 517

Human   518 PEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTS 582
            |||:|||.|||.||.||.|||.|||||:..|.:|.|||.| :|.:|.|||:|||||||.|   |:
  Fly   518 PEKTVRDPAFKTIRGFLGKLEKVSEDPSLRETMEADVHTA-TPSIGNAAATWAGWAVTAV---TA 578

Human   583 KLIRSHPTTAPTETNIPQRP-TPEGVPAPAPTPVPA-------TPTTSGHWETQEEDKDT---AE 636
            |..||.     ::::.|:.| |...:..||....|:       |.:.:.....:.|..||   |.
  Fly   579 KFYRSQ-----SDSSRPRPPLTGRNLSKPASLEQPSSSSLSTTTSSVTSMTSLEHESNDTSASAS 638

Human   637 DSSTADRWDDEDWGSLE--QEAESVLAQQDDWSTGGQVSRASQVSNS----DHKSSKSPESDWSS 695
            |....| ||:|:||.::  |:..|.||..   |..|.:..|:.:|..    |::...|.|.|...
  Fly   639 DYGNND-WDNENWGEMDTSQDPSSPLAAS---SNNGALMAANALSEVRDGWDNEEWGSLEEDPCE 699

Human   696 WEAEGSWEQGWQE--------PSSQEPP-----PDGTRLASEYNWGGPESSDKGDPFATLSAR-- 745
            .|.:...||..|:        .||.:|.     |...:...:......|.:|..:|.|.|::.  
  Fly   700 EEEQAEQEQQQQQLARQSISSTSSSQPNQRPLLPHQQQYPHQQQLQQHELNDLIEPLAKLNSHVT 764

Human   746 -PSTQP--RP-----------------------------------------DSWGEDNWEGL-ET 765
             ||.|.  ||                                         |||.:..:|.| |:
  Fly   765 SPSKQSMLRPKELPNLSSSNTSPTSATANCNNISPPSSHLNNSTHNANWNSDSWADGEFEPLDES 829

Human   766 DSRQVKAELARKKREE----RRREMEAKRAERKVAKGPMKLGARKL 807
            .....|.:.||:||||    |:||:||:||:|  |.|||||||:||
  Fly   830 GFGNAKLDEARRKREEKKLQRQRELEARRAQR--ASGPMKLGAKKL 873

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCYL1NP_065731.3 PK_SCY1_like 20..296 CDD:270913 144/277 (52%)
HEAT repeat 314..336 CDD:293787 13/21 (62%)
HEAT 1 350..388 21/37 (57%)
HEAT repeat 351..372 CDD:293787 13/20 (65%)
HEAT repeat 384..417 CDD:293787 23/32 (72%)
HEAT 2 389..427 28/37 (76%)
HEAT repeat 427..458 CDD:293787 22/30 (73%)
HEAT repeat 467..499 CDD:293787 21/31 (68%)
HEAT repeat 505..530 CDD:293787 17/24 (71%)
HEAT 3 507..545 28/37 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..566 13/25 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..646 15/69 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..808 60/218 (28%)
Interaction with COPB1. /evidence=ECO:0000250 793..808 11/15 (73%)
yataNP_651722.1 Protein Kinases, catalytic domain 30..294 CDD:473864 139/264 (53%)
HEAT repeat 313..339 CDD:293787 15/25 (60%)
HEAT repeat 351..375 CDD:293787 15/23 (65%)
HEAT repeat 388..417 CDD:293787 21/28 (75%)
HEAT repeat 427..458 CDD:293787 22/30 (73%)
HEAT repeat 467..493 CDD:293787 18/25 (72%)
HEAT repeat 504..530 CDD:293787 18/25 (72%)
DUF4078 <838..859 CDD:463837 11/20 (55%)

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