Protein Alignment SCYL1 and Scyl1

DIOPT Version :10

• Sequence 1: NP_065731.3
• Gene: SCYL1 / 57410
• HGNCID: 14372
• Length: 808
• Species: Homo sapiens
• Sequence 2: XP_006230811.3
• Gene: Scyl1 / 293684
• RGDID: 1307330
• Length: 879
• Species: Rattus norvegicus
• Alignment Length: 810
• Identity: 733/810 - (90%)
• Similarity: 758/810 - (93%)
• Gaps: 6/810 - (0%)

Human     1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAF 65
            ||||||||||||||||.|||||||.||||.|||||||||||.|||||||||||||||||||||||
  Rat    74 MWFFARDPVRDFPFELNPEPPEGGPPGPWVLHRGRKKATGSAVSIFVYDVKPGAEEQTQVAKAAF 138

Human    66 KRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSF 130
            ||.||||||||||||||||||||||:|||||||||.|||||.|||||||.|:|||||||||||||
  Rat   139 KRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTYLKARAEAGGLKEQELSWGLHQIVKALSF 203

Human   131 LVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGR 195
            |||||:||||||||||||||:|||||||||||||||||||||||.||||||||||||||||||.|
  Rat   204 LVNDCNLIHNNVCMAAVFVDKAGEWKLGGLDYMYSAQGNGGGPPNKGIPELEQYDPPELADSSSR 268

Human   196 VVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQN 260
            .|:||||||||||||||||||||.||||.||||||||||:||.||||||||||||||||||||||
  Rat   269 AVKEKWSADMWRLGCLIWEVFNGSLPRATALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQN 333

Human   261 CRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGN 325
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
  Rat   334 CRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGN 398

Human   326 AGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIF 390
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
  Rat   399 AGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRVRLLQQMEQFIQYLDEPTVNTQIF 463

Human   391 PHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKI 455
            |||.|||||||||||||||||||||||||:|.||||||:||||||||||:|||||||||||||||
  Rat   464 PHVTHGFLDTNPAIREQTVKSMLLLAPKLSETNLNVELLKHFARLQAKDDQGPIRCNTTVCLGKI 528

Human   456 GSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEK 520
            |||||||||||||||||||||:|||||||||||||||||||||||:|||.|||||||||||||||
  Rat   529 GSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKILPVLCGLTVDPEK 593

Human   521 SVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLI 585
            ||||||||.||||||||||||||||||.|:|||||||||||.|||||||||||||||||||||||
  Rat   594 SVRDQAFKTIRSFLSKLESVSEDPTQLAEIEKDVHAASSPGTGGAAASWAGWAVTGVSSLTSKLI 658

Human   586 RSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWG 650
            |:|||..|:|..:||||.|||.|||||.|..|||.||||.||||||||.||||:|||||||||||
  Rat   659 RTHPTPVPSEAAVPQRPVPEGDPAPAPAPASATPATSGHRETQEEDKDAAEDSATADRWDDEDWG 723

Human   651 SLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPP 715
            ||| ||||||||||||||.||.:||.|||:|||||.   :|.|||||.||||:||||||||.|||
  Rat   724 SLE-EAESVLAQQDDWSTKGQGNRAGQVSHSDHKSL---DSHWSSWEVEGSWDQGWQEPSSVEPP 784

Human   716 PDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPR--PDSWGEDNWEGLETDSRQVKAELARKK 778
            |:||||||||||||.|.||||||||.||.|||||||  |||||||||||||.:||||||||||||
  Rat   785 PEGTRLASEYNWGGAEPSDKGDPFAALSVRPSTQPRPDPDSWGEDNWEGLEAESRQVKAELARKK 849

Human   779 REERRREMEAKRAERKVAKGPMKLGARKLD 808
            ||||||||||||||:|..||||||||||||
  Rat   850 REERRREMEAKRAEKKATKGPMKLGARKLD 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCYL1	NP_065731.3	PK_SCY1_like	20..296	CDD:270913	256/275 (93%)
		HEAT repeat	314..336	CDD:293787	21/21 (100%)
		HEAT 1	350..388		36/37 (97%)
		HEAT repeat	351..372	CDD:293787	19/20 (95%)
		HEAT repeat	384..417	CDD:293787	31/32 (97%)
		HEAT 2	389..427		34/37 (92%)
		HEAT repeat	427..458	CDD:293787	28/30 (93%)
		HEAT repeat	467..499	CDD:293787	30/31 (97%)
		HEAT repeat	505..530	CDD:293787	23/24 (96%)
		HEAT 3	507..545		36/37 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..566		22/25 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..646		42/58 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..808		125/151 (83%)
		Interaction with COPB1. /evidence=ECO:0000250	793..808		11/14 (79%)
Scyl1	XP_006230811.3	None