Protein Alignment SCYL1 and ppk3

DIOPT Version :10

• Sequence 1: NP_065731.3
• Gene: SCYL1 / 57410
• HGNCID: 14372
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_594300.1
• Gene: ppk3 / 2542741
• PomBaseID: SPAC15A10.13
• Length: 637
• Species: Schizosaccharomyces pombe
• Alignment Length: 698
• Identity: 178/698 - (25%)
• Similarity: 295/698 - (42%)
• Gaps: 138/698 - (19%)

Human    12 FPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNI 76
            ||::|..:.|... ...|.|..|..:.:..|.|:|...:.. ..|..::|..|.:..||||||.|
pombe    18 FPYDLNEKIPLSS-NSVWTLQTGSIRESAQPCSVFSISLST-HPEWAELADRACETMKTLRHPCI 80

Human    77 LAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKEL--EI-SWGLHQIVKALSFLVNDCSLI 138
            :.|:...::...|::.||.|.|:         ...|.||  || ::||.::..||||| ||.:::
pombe    81 IKYLSTYKSSTHLYIATETVRPV---------TTELNELSAEIKTYGLWRVSAALSFL-NDKNIV 135

Human   139 HNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPE-LADSSGRVVREKWS 202
            |.|:.|::|:::.|.||.:|  |:..:.                  |.|: :.|:..:::  .||
pombe   136 HGNLQMSSVYLNSADEWIIG--DFFLAG------------------DSPQFIKDNHDKIL--NWS 178

Human   203 -------------------ADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANP 248
                               .|.:.||..|..::||   ....|...|.||..:.....:|:....
pombe   179 RLVPFEIQSSTLNSASFIYLDSYELGKFISHLYNG---TPGDLSQRGNIPANIFVSAKKLLNVEG 240

Human   249 KVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKV 313
            |.:...:.||:....||||.....:.....|.|::|.|..::.|..|.||..|:..|:::.:..|
pombe   241 KQKLLASEFLKLGERPGGFFRTHLITLYELLSEVRINEEEDRVKLKQLLSSKLEVIPKNYIQKVV 305

Human   314 LPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQ 378
            |..|...........|| ..|||..:.:...       |.:.|.|.    ...:.||:|....|:
pombe   306 LNILFLLLSIDTHSDVV-ELLFKCAQIVKGR-------PDIEKDFG----VPLLSLLKQQSVPIR 358

Human   379 ------YLDEPTV---------NTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVEL 428
                  .::.|.|         :..:|.::|.   ..:|.::|..:....::||||::..||.||
pombe   359 GLLLSGIINNPDVLPKNIYEDTSFSVFANLVR---SNSPTLKEHAIVVFSIIAPKLSKKTLNNEL 420

Human   429 MKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAA 493
            ::..|.:| .|:...:|.|:|:|||||..||.||.|..||.:|.||:.:|||.|:|.|.:....:
pombe   421 LRSLAVVQ-NDQHPTLRTNSTICLGKIAEYLDASVRKPVLAAALSRSLKDPFVPAREAALKVLLS 484

Human   494 THNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAAS 558
            ..|.:...|.|.|:.|.:..|.:|..:.:|..|......|||::::.:     |.|.|.    .|
pombe   485 VQNYFDTKDVAIKLFPSVVPLLIDENEGIRRTAEDVTDQFLSRIKNFN-----LGEKEN----VS 540

Human   559 SPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTS- 622
            :|      |.:.|       |..||.|  |.::|....:|..:  .|.:.....|........|
pombe   541 AP------AKFNG-------SFWSKFI--HSSSASPSPSIDMK--KESLELKNDTTEIKEKKNSK 588

Human   623 ----GHWETQEED-----KDTAE--DSSTADRWDDED---------WG 650
                |:.|..:::     .:|.|  |.|..:.|:||:         ||
pombe   589 SRVVGNTENSKDEFNNPLFETEEQIDESWMENWNDEEETENNVEESWG 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCYL1	NP_065731.3	PK_SCY1_like	20..296	CDD:270913	74/298 (25%)
		HEAT repeat	314..336	CDD:293787	5/21 (24%)
		HEAT 1	350..388		9/52 (17%)
		HEAT repeat	351..372	CDD:293787	5/20 (25%)
		HEAT repeat	384..417	CDD:293787	5/41 (12%)
		HEAT 2	389..427		10/37 (27%)
		HEAT repeat	427..458	CDD:293787	13/30 (43%)
		HEAT repeat	467..499	CDD:293787	12/31 (39%)
		HEAT repeat	505..530	CDD:293787	6/24 (25%)
		HEAT 3	507..545		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..566		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..646		13/70 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..808
		Interaction with COPB1. /evidence=ECO:0000250	793..808
ppk3	NP_594300.1	PK_SCY1_like	25..290	CDD:270913	75/301 (25%)
		HEAT repeat	306..330	CDD:293787	7/24 (29%)
		HEAT repeat	342..370	CDD:293787	5/31 (16%)
		HEAT repeat	380..410	CDD:293787	5/32 (16%)
		HEAT repeat	419..445	CDD:293787	10/26 (38%)
		HEAT repeat	456..485	CDD:293787	11/28 (39%)