DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCYL1 and scyl-1

DIOPT Version :10

Sequence 1:NP_065731.3 Gene:SCYL1 / 57410 HGNCID:14372 Length:808 Species:Homo sapiens
Sequence 2:NP_001366843.1 Gene:scyl-1 / 179789 WormBaseID:WBGene00012337 Length:820 Species:Caenorhabditis elegans


Alignment Length:886 Identity:305/886 - (34%)
Similarity:445/886 - (50%) Gaps:158/886 - (17%)


- Green bases have known domain annotations that are detailed below.


Human     3 FFARDPVRDFPFELIPEPPEGGLPGP-------WALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 60
            ||.|||...||::         :||.       .::....|||....::...:|      .::..
 Worm     8 FFQRDPKSQFPYD---------IPGAEEHFFDRVSIGNSFKKAEPGELATIFWD------NRSST 57

Human    61 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAG---GLKELEISWGLH 122
            .|...::.||:|||||:.|:|.:|.|...::|||...||.:|||   |||   ..||..:|||:.
 Worm    58 LKQQAQKLKTMRHPNIITYLDSIELEGTFYLVTEKCKPLELYLK---EAGLTESQKEFVVSWGMF 119

Human   123 QIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPP 187
            |::.||.|: ::..|.|.|: ...|||...|:||:|||..:..                  :..|
 Worm   120 QLLNALKFM-HEAKLSHENL-RKGVFVTAGGDWKIGGLHLVTG------------------FTSP 164

Human   188 ELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRP 252
            :              .|:.:|..::||||||........:.|||||:.:...| :.:||....|.
 Worm   165 Q--------------TDLNQLAIVLWEVFNGFNDAITRPQAPGKIPQRIHELY-KKIGAQSAARL 214

Human   253 NPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQL 317
            .....::..|..||::.|:||:|.|||||.::||.:|||.||..|.:::|.||||..::|:||:|
 Worm   215 AVCDIIKEYRLTGGYLKNKFVDTLLFLEEFELKEASEKQSFFMHLRENIDIFPEDVAKYKILPKL 279

Human   318 LTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDE 382
            :..:|:|:||..:|.||||:|:.|...|||:.|:|.:.|:|.|.||..|::||:::::|..:|..
 Worm   280 ILTYEYGDAGPNILIPLFKLGRLLDEAEYQRTIVPCLCKLFGSPDRTTRVKLLERIDEFAPHLTP 344

Human   383 PTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCN 447
            ..:|.:||.::..||||||||:||.|||:|:.||.|||..||||||||:.||||..||.|.||.|
 Worm   345 QILNDKIFGNLTSGFLDTNPAVRESTVKAMVSLAEKLNYNNLNVELMKYLARLQGGDEHGGIRTN 409

Human   448 TTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLC 512
            ||:||||||..::.:.|..:|.|||:||.:|||||||:|.||..:||...|.:.:.:.:|:|.|.
 Worm   410 TTICLGKIGHLIAPAKRQGILISAFTRALKDPFAPSRMASVLALSATQQFYPLVEISNRIVPSLI 474

Human   513 GLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMG-GAAASWAGWAVTG 576
            .||.||||.||||||||||.||.|||..||:|..:.|:|..|.|.:|..:. .....||.||   
 Worm   475 PLTCDPEKQVRDQAFKAIRGFLEKLEKASENPACIPELEAGVKAGASSILDHEKVPQWASWA--- 536

Human   577 VSSLTSKLIRSHPTT-----APTETNIPQRPTPEGVPAPAPT-----------PVPATPTTSGHW 625
            :.||:.|..:..|..     ||...:...||.     .|.||           |.||.|.|:..|
 Worm   537 LKSLSGKFYKGPPPAEVKPGAPATADTSSRPV-----TPNPTAEKEKSSTVLKPTPAKPATNDGW 596

Human   626 E--TQEEDKDTAEDS--STADRW--------DDEDWG------------------SLEQEAESVL 660
            .  |...|....:||  |..|.|        |.:|||                  .....:.|..
 Worm   597 GDLTDGGDMFAVKDSNDSAIDDWADINTKSNDADDWGVGWDTPIATATSSPIPGVKKSSSSSSAA 661

Human   661 AQQDDWSTGGQVSRASQVSNSD-HKSSKSPESD-------WSSWEAEGSWEQGWQEPSSQEPPPD 717
            |::   .|.|:::..|.::.|. .|.:|....|       .|:..|.||    ..:|:|.....:
 Worm   662 AKK---PTIGRLNLGSNLAGSSAQKQTKKAIDDNIDALLGISAPPAAGS----SVKPNSLNALMN 719

Human   718 GTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNW--EGLETDSRQVKAELARKK-- 778
            .:..::...||      ..||..|.:...:.:    .|.:|.|  ..:.::..|..|.|...|  
 Worm   720 NSSSSTNTGWG------FDDPLPTTNNSSANK----GWDDDGWGDNSMSSNVLQPTAVLQPTKMK 774

Human   779 --REERRREM----EAKRAE---RKVAKGPMKLGA--RKLD 808
              ::.||.||    ||:|.|   ||.:.|.|||.:  :|:|
 Worm   775 DDKDARRAEMQARNEARRKEQMDRKKSAGAMKLASVEKKMD 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCYL1NP_065731.3 PK_SCY1_like 20..296 CDD:270913 87/285 (31%)
HEAT repeat 314..336 CDD:293787 10/21 (48%)
HEAT 1 350..388 13/37 (35%)
HEAT repeat 351..372 CDD:293787 9/20 (45%)
HEAT repeat 384..417 CDD:293787 18/32 (56%)
HEAT 2 389..427 24/37 (65%)
HEAT repeat 427..458 CDD:293787 22/30 (73%)
HEAT repeat 467..499 CDD:293787 18/31 (58%)
HEAT repeat 505..530 CDD:293787 16/24 (67%)
HEAT 3 507..545 26/37 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..566 8/26 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..646 21/86 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..808 42/172 (24%)
Interaction with COPB1. /evidence=ECO:0000250 793..808 7/16 (44%)
scyl-1NP_001366843.1 Protein Kinases, catalytic domain 58..>165 CDD:473864 44/129 (34%)
HEAT repeat 313..337 CDD:293787 9/23 (39%)
HEAT repeat 346..379 CDD:293787 18/32 (56%)
HEAT 361..492 CDD:441023 78/130 (60%)
HEAT repeat 389..420 CDD:293787 22/30 (73%)
HEAT repeat 429..455 CDD:293787 16/25 (64%)
HEAT repeat 466..492 CDD:293787 16/25 (64%)
HEAT repeat 507..539 CDD:293787 9/34 (26%)

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