Protein Alignment CG34367 and PHOX2B

DIOPT Version :10

• Sequence 1: NP_001097140.1
• Gene: CG34367 / 5740879
• FlyBaseID: FBgn0085396
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_003915.2
• Gene: PHOX2B / 8929
• HGNCID: 9143
• Length: 314
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 83/299 - (27%)
• Similarity: 108/299 - (36%)
• Gaps: 92/299 - (30%)

  Fly   128 VDSQPEDPKMSGLPTASITECTED----------------------SNTPKLAPDK--------- 161
            ::|...:..|:|:.|:|:.....|                      |..|.|.|..
Human     9 LNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDH 73

  Fly   162 -----PLLPEECVSPEPSRNREHCDPLDTSLVNTKQRRSRTNFTLDQLNELERLFEETHYPDAFM 221
                 ..:|.:..:.....|.:.           ||||.||.||..||.||||:|.||||||.:.
Human    74 QSSPYAAVPYKLFTDHGGLNEKR-----------KQRRIRTTFTSAQLKELERVFAETHYPDIYT 127

  Fly   222 REELSQRLGLSEARVQVWFQNRRAKCRKHENQMHKGFLVGSRSPPIATPLEPCRVAPYVSLAALR 286
            ||||:.::.|:||||||||||||||.||.|                       |.|...:.||..
Human   128 REELALKIDLTEARVQVWFQNRRAKFRKQE-----------------------RAAAAAAAAAKN 169

  Fly   287 SSSVPSHPAAATSSNPQAPGVSGTSSSGKVVTVDSPHNHNPAISRSAIKQFSSTVAAAAAFSAFD 351
            .||.....::....:.:|......|:.|     ..| |.||..|..|........:.|.|..|..
Human   170 GSSGKKSDSSRDDESKEAKSTDPDSTGG-----PGP-NPNPTPSCGANGGGGGGPSPAGAPGAAG 228

  Fly   352 P----------------AIISVAAHQYAAAITNGTVPAG 374
            |                |..:.||...|||...|...||
Human   229 PGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAG 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34367	NP_001097140.1	Homeodomain	193..249	CDD:459649	38/55 (69%)
		OAR	392..410	CDD:461067
PHOX2B	NP_003915.2	Homeodomain	99..155	CDD:459649	38/55 (69%)
		polyalanine repeat	241..260		6/18 (33%)