Protein Alignment CG34367 and PITX2

DIOPT Version :10

• Sequence 1: NP_001097140.1
• Gene: CG34367 / 5740879
• FlyBaseID: FBgn0085396
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 317
• Identity: 86/317 - (27%)
• Similarity: 134/317 - (42%)
• Gaps: 47/317 - (14%)

  Fly   104 LSPTLHKAAVEPKPKNWLISEDLDVDSQPE--DPKMSGLPTASITECTEDSNTPKLA-PDKPL-- 163
            ||.....:...|:|   |....:....||.  |.....|...:|:    |:::|:.| .||..
Human    19 LSAVSSSSCHHPQP---LAMASVLAPGQPRSLDSSKHRLEVHTIS----DTSSPEAAEKDKSQQG 76

  Fly   164 LPEECVSPEPSRNREHCDPLDTSLVNTKQRRSRTNFTLDQLNELERLFEETHYPDAFMREELSQR 228
            ..|:..:.:||:.:             :|||.||:||..||.|||..|:...|||...|||::..
Human    77 KNEDVGAEDPSKKK-------------RQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVW 128

  Fly   229 LGLSEARVQVWFQNRRAKCRKHENQMHKGFLVGSRSPPIATPLEPCRVAPYVSLAALRSSSVPSH 293
            ..|:||||:|||:|||||.||.|.............|.....::|            .....|.:
Human   129 TNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQP------------YDDMYPGY 181

  Fly   294 PAAATSSNPQAPGVSGTSSSGKVVTVDSPHNHNPAISRSAIKQFSSTVAAAAAFSAFDPAIISVA 358
                :.:|..|.|::..|.|.|.....:..|.||..|:|.....:|..:.:.:.|....|:..|.
Human   182 ----SYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVP 242

  Fly   359 AHQYAAA--ITNGTVPAGLFSVP----QYSINLAAFAAAHSKSSSIADLRMKAKKHS 409
            .....:.  :.|.:.|:...:||    .|:.....:....:.:||:|.||:|||:||
Human   243 GSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHS 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34367	NP_001097140.1	Homeodomain	193..249	CDD:459649	31/55 (56%)
		OAR	392..410	CDD:461067	10/18 (56%)
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	31/55 (56%)
		OAR	282..299	CDD:461067	8/16 (50%)