Protein Alignment CG34367 and PDX1

DIOPT Version :10

• Sequence 1: NP_001097140.1
• Gene: CG34367 / 5740879
• FlyBaseID: FBgn0085396
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 238
• Identity: 62/238 - (26%)
• Similarity: 87/238 - (36%)
• Gaps: 56/238 - (23%)

  Fly   131 QPEDPKMSGLPTASITECTEDSNTPKLAP-------DKPL-------LPEECVSPEPSRN--REH 179
            ||..|.....|.|  ....|..:.|.::|       |.|.       ||.:...|.|...  .|.
Human    41 QPPPPPPHPFPGA--LGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEG 103

  Fly   180 CDP--LDTS---------LVNTK-------------------QRRSRTNFTLDQLNELERLFEET 214
            .:|  |:..         :.:||                   .:|:||.:|..||.|||:.|...
Human   104 AEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFN 168

  Fly   215 HYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKHENQMH-KGFLVGSRSPPIATPLEPCRVAP 278
            .|.....|.||:..|.|:|..:::||||||.|.:|.|::.. .|..||...  :|.|.:.|.|..
Human   169 KYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGG--VAEPEQDCAVTS 231

  Fly   279 YVSLAAL-----RSSSVPSHPAAATSSNPQAPGVSGTSSSGKV 316
            ...|.||     ...:||.....|.......||:|.:.....|
Human   232 GEELLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSV 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34367	NP_001097140.1	Homeodomain	193..249	CDD:459649	24/55 (44%)
		OAR	392..410	CDD:461067
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		8/31 (26%)
		Antp-type hexapeptide	118..123		0/4 (0%)
		Homeodomain	147..203	CDD:459649	24/55 (44%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		19/76 (25%)