Protein Alignment CG34458 and KLK14

DIOPT Version :10

• Sequence 1: NP_001097340.1
• Gene: CG34458 / 5740868
• FlyBaseID: FBgn0085487
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_071329.3
• Gene: KLK14 / 43847
• HGNCID: 6362
• Length: 251
• Species: Homo sapiens
• Alignment Length: 1152
• Identity: 204/1152 - (17%)
• Similarity: 364/1152 - (31%)
• Gaps: 419/1152 - (36%)

  Fly    18 SSSGKQVVELNGYVIILVESRDGKIKLYGSPADKDNL-----EVADEILDVNERKLED------- 70
            |::|.:|:   |.|       |....|.|..:.:|:.     ||.:.:|: |.:.||.
Human   396 STAGSEVI---GDV-------DEGADLLGEFSVRDDFFGMGKEVGNLLLE-NSQLLETKNALNVV 449

  Fly    71 -----------SPRAEVIKHIHECIQSCMIKL--RVKRRSDSRLAGELGNAVQDAFVIAVEQQAR 122
                       |...||:|...|..:...:||  |:|     .|..||.....:|  :...::.|
Human   450 KNDLIAKVDQLSGEQEVLKGELEAAKQAKVKLENRIK-----ELEEELKRVKSEA--VTARREPR 507

  Fly   123 ERLQRLSAL-------------KRITPVDMSQLSIKARPHREMAVDVPES------FIARNKTPP 168
            |.::.:|:.             :|.|.|:|:::.::...::|..:::.|:      ..|..:.|.
Human   508 EEVEDVSSYLCTELDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPS 572

  Fly   169 RYPPPRSTV-----TAASAAASTPATPASTQVNHVSNAMPQVAKHHHHHNHHHQQQQHPNHHLHH 228
            .....:||:     ...|:::|.|  ||                          ::.:|:.:: |
Human   573 VQEKKKSTIWQFFSRLFSSSSSPP--PA--------------------------KRSYPSVNI-H 608

  Fly   229 HHPPSSVHHNTHHHHGGGGVSLELEPLDSYSERHLSS---LDSSSQEY--VKKGIISGGGVGGGG 288
            :..|::...:...:|....:|....||:.:.:...:|   .:...::|  |::.:.:..|
Human   609 YKSPTTAGFSQRRNHALCQISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDG----- 668

  Fly   289 SSKAPSSLGSVTSEFEPSLNGFG-PLHGKHHHHSTVGGGGGDLLRGSLSTNRSPSPSSSGDLGPP 352
                             .|...| .|..|:...|..||.....:
Human   669 -----------------RLQACGWSLPAKYKQLSPNGGQEDTRM--------------------- 695

  Fly   353 EYDVGPHRELPVDVPDSFVEMVKGPPRYPPPKPLIIKDAIRKKESCSSSESIDKPKPQTQSPSPP 417
                   :.:||             |.|  .:||:.||. ..|..|::..::...||
Human   696 -------KNVPV-------------PVY--CRPLVEKDP-STKLWCAAGVNLSGWKP-------- 729

  Fly   418 ARNELNGSSKPVPPP-RDHLRIEKDGRLTNRAPVPAPQVPDRKIVPNASSQHQHIGQVLEPTPDQ 481
              ||.:.|:.|.|.| ||.|..:::|....::..|:|:....|.||.|.:....:
Human   730 --NEEDSSNGPKPAPGRDPLTCDREGEGEPKSTHPSPEKKKAKEVPEADATSSRV---------- 782

  Fly   482 LDSIKKFQEQLRRRREDEERIAAQNDFLRNSLRGSQRLRALQDNPIEKPPVGVDNEAYADDEVVA 546
                                      ::..|...:.::..:..|   :|...||.....:..|:.
Human   783 --------------------------WILTSTLTTSKVVIIDAN---QPGTVVDQFTVCNAHVLC 818

  Fly   547 VAAEKIIGYGELVAALQRLQGHLNKHGLAA---LAG--------RVTAAQSLLLGPGIARALAVR 600
            :::.......:.......|...:|.....|   |||        |....:|.....|       .
Human   819 ISSIPAASDSDYPPGDMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRG-------D 876

  Fly   601 TAVLERRRPKIP-------NPICPNAQALAKDCVESLAQSRSQTAIELCDLLSTYEMEGLLLAHD 658
            |.||::.:..:.       ||.....:|.....|.....|.|:
Human   877 TPVLDKGQGDVAATANGKVNPSQSTEEATEATEVPDPGPSESE---------------------- 919

  Fly   659 RIASTTDRSPIASYGGSPITVPVPLGTASNNTTSNNTTTSNNSI---------NNNTLTSAVKPA 714
              |:|....|:..:   ..|.|.|..::|....|.|.:.|:.||         .::..||:..|
Human   920 --ATTVRPGPLTEH---VFTDPAPTQSSSTQPASENGSESDGSIVQPQVEPSGESSATTSSAAP- 978

  Fly   715 TVMPSIPNNASLVNNNNNNIAK-------------------REPMSVPLGVL------RDGSQD- 753
            |:.....|....|::...|..|                   |..:::..|.|      .||..|
Human   979 TMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDL 1043

  Fly   754 ---------------------------------HI---KIIQIEKSSEPLGATIRNE-------- 774
                                             |:   |.:|||||.:   |..|.|
Human  1044 SNYHLMDLGHPHHSIRCMAVVDDRVWCGYKNKVHVIQPKTMQIEKSFD---AHPRRESQVRQLAW 1105

  Fly   775 -GEAVVIGRVVRGGAAEKSGLLHEGDEILEVN---------GIEMRGKSVNDVCALLGSMTGTLT 829
             |:.|.:.  :|..:..:....|....:.:|:         |....|.|...:.|||  :.|...
Human  1106 IGDGVWVS--IRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALL--IAGNRL 1166

  Fly   830 FLVVPAGVPQILPGLGMRDPPVLH------VRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISR 888
            ::....||...:|   :.:..|||      :||: ...|..         |...:.|.::||
Human  1167 WVGTGNGVVISIP---LTETVVLHRGQLLGLRAN-KTSPTS---------GEGTRPGGIIHV--- 1215

  Fly   889 DDPNWWQAYREGEEDQTLAGLIPSQS-------FQHQRESMK--LAIAGEVGLRTRKDINGKA-- 942
                    |.:...|:|.:..||..|       |...|:::|  :::.|.| |.|   :||..
Human  1216 --------YGDDSSDKTASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNV-LAT---LNGSVLD 1268

  Fly   943 ----GGGSTLLCARKGRKKKKKA---SSEHGYPLYATATADDPDPEE 982
                |.|.....|....:|.|.|   |...||..:.....:|.:.||
Human  1269 SPSEGPGPAAPAADAEGQKLKNALVLSGGEGYIDFRIGDGEDDETEE 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34458	NP_001097340.1	Tryp_SPc	32..254	CDD:238113	46/270 (17%)
KLK14	NP_071329.3	Tryp_SPc	25..247	CDD:238113