DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and PMA1

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_011507.1	Gene:	PMA1 / 852876	SGDID:	S000002976	Length:	918	Species:	Saccharomyces cerevisiae

Alignment Length:	937	Identity:	248/937 - (26%)
Similarity:	404/937 - (43%)	Gaps:	205/937 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DVETDN-------HKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQPPT--PKWIVFL 82
            |.::||       ...||.|  |.|:|||:.||:..|...|.:..|.|.:..:..:  .|:::|
Yeast    58 DEDSDNDGPVAAGEARPVPE--EYLQTDPSYGLTSDEVLKRRKKYGLNQMADEKESLVVKFVMF- 119

  Fly    83 KTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQVHKSSSIM 147
              ..|....::.|.:.|. .|.           .|.:..|:...:|::..|: .:.|..::.||:
Yeast   120 --FVGPIQFVMEAAAILA-AGL-----------SDWVDFGVICGLLMLNAGV-GFVQEFQAGSIV 169

  Fly   148 DSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRIL-EAHGLKVDNSSLTGES 211
            |..|..:...|.|||:|::..:.::|:|.|||::::.|..:|.|.||: |...|::|.|::||||
Yeast   170 DELKKTLANTAVVIRDGQLVEIPANEVVPGDILQLEDGTVIPTDGRIVTEDCFLQIDQSAITGES 234

  Fly   212 EPQVRSTEFTHENPLETKNLA---------FFSTNVLEGTCRGVVIATGDSTVMGRIA---NLAA 264
                               ||         |.|:.|..|....||.||||:|.:||.|   |.||
Yeast   235 -------------------LAVDKHYGDQTFSSSTVKRGEGFMVVTATGDNTFVGRAAALVNKAA 280

  Fly   265 G----LDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGL 325
            |    ..:|.:.|.  |.|.:..|....::....|:.   |.|  .:..:.:.:||.:..||.||
Yeast   281 GGQGHFTEVLNGIG--IILLVLVIATLLLVWTACFYR---TNG--IVRILRYTLGITIIGVPVGL 338

  Fly   326 LVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESD 390
            ...||..:.:.|..:|.|..:|:.|.|:|:|.....:|||||||||:|:::: |
Yeast   339 PAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSL-H----------- 391

  Fly   391 TTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNG-NASEAALLKFTETIFA 454
                   ..:.:|..|.:.|.:.|.|..|.:.||.......|.|.:.. ..::.||.|:
Yeast   392 -------EPYTVEGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLKQYPKAKDALTKY------ 443

  Fly   455 GIGAFRQKHIKLTEI-PFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVE- 517
                      |:.|. ||:...|...:|.|  |.:|..||.:||||..:|.          :||
Yeast   444 ----------KVLEFHPFDPVSKKVTAVVE--SPEGERIVCVKGAPLFVLK----------TVEE 486

  Fly   518 ---LTPTLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISL 579
               :...:...:|....|:...|.|.||.|     ..:....:|              .||::..
Yeast   487 DHPIPEDVHENYENKVAELASRGFRALGVA-----RKRGEGHWE--------------ILGVMPC 532

  Fly   580 IDPPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIITTPTAEDIAKQRGVTVLDIDSR 644
            :||||......|::.|..|:||.|:|||          :|||     |::..:|.|   |..:..
Yeast   533 MDPPRDDTAQTVSEARHLGLRVKMLTGD----------AVGI-----AKETCRQLG---LGTNIY 579

  Fly   645 QATAIVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSP 709
            .|..:.:.||  .:|...||  ..:..|...||...||.|..:||..|.||.:||:|||||||:|
Yeast   580 NAERLGLGGG--GDMPGSEL--ADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAP 640

  Fly   710 ALKRADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLP-EI 773
            :||:||.|:|:. ..:|.::.|||::.|....::|:..::..|.||..:...:.|.:..:|. ||
Yeast   641 SLKKADTGIAVE-GATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEI 704

  Fly   774 VPFLFFVIFDIPLALGTIAILCI--DIGTDMLPAISLAYEKA---ESDIMARMPRDPFEDRLVNK 833
            ...|:..|.|..|.:..|..:.|  |:.|     :::||:.|   ...:...:|      ||...
Yeast   705 FLGLWIAILDNSLDIDLIVFIAIFADVAT-----LAIAYDNAPYSPKPVKWNLP------RLWGM 758

  Fly   834 KLILMAYLQIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKN-VEDLEDGYGQEW-TYRE 896
            .:||      |::..:..:.|...:....|       ||.:::.:.| :..|:....:.| .:..
Yeast   759 SIIL------GIVLAIGSWITLTTMFLPKG-------GIIQNFGAMNGIMFLQISLTENWLIFIT 810

  Fly   897 RKVLEY--------TAGTGFFVSIVVT 915
            |....:        .||..|.|.|:.|
Yeast   811 RAAGPFWSSIPSWQLAGAVFAVDIIAT 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	248/937 (26%)
		Cation_ATPase_N	29..102	CDD:214842	21/81 (26%)
		E1-E2_ATPase	123..354	CDD:278548	72/247 (29%)
		Cation_ATPase	416..509	CDD:289987	25/94 (27%)
		COG4087	<673..738	CDD:226572	30/64 (47%)
		Cation_ATPase_C	785..994	CDD:279079	28/146 (19%)
PMA1	NP_011507.1	P-type_ATPase_H	87..874	CDD:319771	237/906 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S851
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.790