DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp1a1b

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_571765.1	Gene:	atp1a1b / 64616	ZFINID:	ZDB-GENE-001212-5	Length:	1025	Species:	Danio rerio

Alignment Length:	1011	Identity:	636/1011 - (62%)
Similarity:	785/1011 - (77%)	Gaps:	11/1011 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNI 68
            |||||     .|:|:||:...||:|:.|:||:.::||..:..||.|.||:...|...|..:|||.
Zfish    21 KKKNK-----NKKKEKDMDELKKEVDLDDHKLTLEELNRKYGTDLNRGLTTARAAEILARDGPNA 80

  Fly    69 LTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTG 133
            |||.|.||:|:.|.|.|||||::|||.|:.|||:.|.||...:.||.:||||||:.|:.:||:||
Zfish    81 LTPPPTTPEWVKFCKQMFGGFSMLLWTGALLCFLAYGIQAAMEDEPANDNLYLGVVLSAVVIITG 145

  Fly   134 LFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAH 198
            .|:|:|..|||.|||||||||||.|.|:|:||.|.|.::|:|.||:||||.|||:|||:||:.:|
Zfish   146 CFSYYQEAKSSKIMDSFKNLVPQQALVVRDGEKNHVNAEEVVVGDLVEVKGGDRIPADLRIIASH 210

  Fly   199 GLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLA 263
            |.||||||||||||||.||.:::::|||||:|:||||||.:|||.||:||:|||.|||||||.||
Zfish   211 GCKVDNSSLTGESEPQTRSPDYSNDNPLETRNIAFFSTNCVEGTARGIVISTGDRTVMGRIATLA 275

  Fly   264 AGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVT 328
            :||:..::|||.||:.||..||..|:.||:|||.:||.|||.:::||:|||||||||||||||.|
Zfish   276 SGLEVGRTPISIEIEHFIHIITGVAVFLGVSFFVLSLALGYSWLEAVIFLIGIIVANVPEGLLAT 340

  Fly   329 VTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTE 393
            |||||||||||||.|||||||||||||||||||||||||||||||||||||:|:|..|.|:||||
Zfish   341 VTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTE 405

  Fly   394 SFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGA 458
            :..|:.|.....::.:|...|.|||.|.|...|.|:|:.|:||.|:|||:||||..|.....:..
Zfish   406 NQSGTSFDRSSATWASLARVAGLCNRAVFLAEQTDVPILKRDVAGDASESALLKCIELCCGSVKD 470

  Fly   459 FRQKHIKLTEIPFNSTEKYQVSVHEFNSSDG---YFIVEMKGAPERILDRCSTIIIQGLSVELTP 520
            .|:|:.|:.|||||||.|||:|||: |.:.|   ..::.|||||||||||||||:|||....|..
Zfish   471 MREKYTKVAEIPFNSTNKYQLSVHK-NPNGGTESKHLLVMKGAPERILDRCSTILIQGKVQALDD 534

  Fly   521 TLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRA 585
            .:|..|:.||||:||:|||||||....||..::|..:.|..:..|||.|||.|:||:|:||||||
Zfish   535 EMKEAFQNAYLELGGLGERVLGFCHFCLPDEEFPEGFPFDTEDVNFPTENLCFVGLMSMIDPPRA 599

  Fly   586 AVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATA 648
            ||||||.||||||::||||||||||||||||:.||||:  ..|.||||.:..:.|.:::.|.|.|
Zfish   600 AVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNEVNPRDAKA 664

  Fly   649 IVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKR 713
            .|||||:|:::..|:||.::.:|.|||||||||||||||||.|||:|.||||||||||||||||:
Zfish   665 CVVHGGDLKDLSCEQLDDILKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKK 729

  Fly   714 ADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLF 778
            |||||||||:||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.
Zfish   730 ADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLL 794

  Fly   779 FVIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQI 843
            |:|.:|||.|||:.|||||:|||||||||||||.||||||.|.||:|..|:|||::||.:||.||
Zfish   795 FIIANIPLPLGTVTILCIDLGTDMLPAISLAYEAAESDIMKRQPRNPKTDKLVNERLISIAYGQI 859

  Fly   844 GVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGF 908
            |:||.:|.|||:|.|::|:||.||||.|||..||.|::.||||.|||:|||.:||::|:|..|.|
Zfish   860 GMIQALAGFFTYFVILSENGFLPSRLLGIRVYWDDKHINDLEDSYGQQWTYEQRKIVEFTCHTAF 924

  Fly   909 FVSIVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIW 973
            |.||||.|..||:||||||||:.||||.|.:|.|.|..|..:|..|.|.|..:..||||.:|..|
Zfish   925 FASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPNW 989

  Fly   974 WIYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            |..|||:.||||.:||.|:.::|||||||||:||||
Zfish   990 WFCAFPYSLLIFIYDEMRKLILRRNPGGWVERETYY 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	628/996 (63%)
		Cation_ATPase_N	29..102	CDD:214842	35/72 (49%)
		E1-E2_ATPase	123..354	CDD:278548	157/230 (68%)
		Cation_ATPase	416..509	CDD:289987	51/95 (54%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	127/208 (61%)
atp1a1b	NP_571765.1	ATPase-IIC_X-K	32..1025	CDD:273445	626/993 (63%)
		Cation_ATPase_N	41..115	CDD:214842	36/73 (49%)
		E1-E2_ATPase	135..366	CDD:278548	157/230 (68%)
		Cation_ATPase	428..523	CDD:289987	51/95 (54%)
		COG4087	608..754	CDD:226572	103/145 (71%)
		Cation_ATPase_C	801..1010	CDD:279079	127/208 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593928
Domainoid	1	1.000	124	1.000	Domainoid score	I5444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D50082at33208
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860