DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp1a1a.4

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_571764.1	Gene:	atp1a1a.4 / 64615	ZFINID:	ZDB-GENE-001212-4	Length:	1024	Species:	Danio rerio

Alignment Length:	1010	Identity:	634/1010 - (62%)
Similarity:	782/1010 - (77%)	Gaps:	11/1010 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PKKKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPN 67
            |||        ||:|:||:...||:|:.|:||:.:|||..:..||...|||...||..|..:|||
Zfish    23 PKK--------GKKKQKDMDELKKEVDLDDHKLTLDELHRKYGTDLTRGLSSSRAKEVLARDGPN 79

  Fly    68 ILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVT 132
            .|||.|.||:|:.|.|.:||||:.|||.|:.|||:.|.||..::.:|.:|||||||.|..:||:|
Zfish    80 ALTPPPTTPEWVKFCKQLFGGFSTLLWIGAILCFLAYGIQAASEDDPTNDNLYLGIVLAGVVIIT 144

  Fly   133 GLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEA 197
            |.|:|:|..|||.||:||||||||.|.|:|:||..::.::|:|.||:||||.|||:|||:||:.|
Zfish   145 GCFSYYQEAKSSKIMESFKNLVPQQALVVRDGEKKSINAEEVVAGDLVEVKGGDRIPADLRIISA 209

  Fly   198 HGLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANL 262
            ||.||||||||||||||.|:.:|:::|||||:|:||||||.:|||.||:||.|||.|||||||.|
Zfish   210 HGCKVDNSSLTGESEPQTRTPDFSNDNPLETRNIAFFSTNCVEGTARGIVINTGDRTVMGRIATL 274

  Fly   263 AAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLV 327
            |:.|:..|:||::||:.||..||..|:.||:|||.:||.|||.:::||:|||||||||||||||.
Zfish   275 ASSLEGGQTPIAKEIEHFIHIITGVAVFLGVSFFILSLILGYGWLEAVIFLIGIIVANVPEGLLA 339

  Fly   328 TVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTT 392
            ||||||||||||||.|||||||||||||||||||||||||||||||||||||:|:|..|.|:|||
Zfish   340 TVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDSQIHEADTT 404

  Fly   393 ESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIG 457
            |:..|:.|.....:::||...|.|||.|.|...|.::|:.|:|..|:|||:||||..|.....:.
Zfish   405 ENQSGTTFDRSSPTWSALARVAGLCNRAVFLADQRNVPILKRDTAGDASESALLKCIELCCGSVN 469

  Fly   458 AFRQKHIKLTEIPFNSTEKYQVSVHEF-NSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPT 521
            ..|:|:.|:.|||||||.|||:|:|:. |||:...::.|||||||||||||||:|||....|...
Zfish   470 EMREKYTKIAEIPFNSTNKYQLSIHKNPNSSEPKHLLVMKGAPERILDRCSTILIQGKQQPLDEE 534

  Fly   522 LKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAA 586
            :|..|:.||:|:||:|||||||....||..::|..:.|..:..|||.|||.|:||:|:|||||||
Zfish   535 MKDAFQNAYVELGGLGERVLGFCHFCLPDDQFPEGFAFDTEEVNFPTENLCFVGLMSMIDPPRAA 599

  Fly   587 VPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAI 649
            |||||.||||||::||||||||||||||||:.||||:  ..|.||||.:..:.|.:::.|.|.|.
Zfish   600 VPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVGEVNPRDAKAC 664

  Fly   650 VVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRA 714
            |||||||:.|..||||.::.:|.|||||||||||||||||.|||:|.||||||||||||||||:|
Zfish   665 VVHGGELKSMSEEELDDILKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKA 729

  Fly   715 DIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFF 779
            ||||||||:||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.|
Zfish   730 DIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLF 794

  Fly   780 VIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIG 844
            :|.:|||.|||:.|||||:||||:||||||||.||||||.|.||:...|:|||::||.|||.|||
Zfish   795 IIANIPLPLGTVTILCIDLGTDMVPAISLAYESAESDIMKRQPRNAKTDKLVNERLISMAYGQIG 859

  Fly   845 VIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFF 909
            ::|.||.||::|.|:||:||.||.|.|||.:||.|.|.||||.|||:|||..||::|:|..|.||
Zfish   860 MMQAVAGFFSYFVILAENGFLPSDLVGIRVNWDDKYVNDLEDSYGQQWTYERRKIVEFTCHTAFF 924

  Fly   910 VSIVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWW 974
            .|||:.|..||:|||||||||:||||.|.:|.|.|..|..:|..|.|.|..:..||||.:|..||
Zfish   925 ASIVIVQWADLIICKTRRNSIVQQGMRNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPCWW 989

  Fly   975 IYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            ..|||:.||||.:||:||:::||:|||||||||||
Zfish   990 FCAFPYSLLIFVYDEARRYILRRSPGGWVEQETYY 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	627/994 (63%)
		Cation_ATPase_N	29..102	CDD:214842	36/72 (50%)
		E1-E2_ATPase	123..354	CDD:278548	155/230 (67%)
		Cation_ATPase	416..509	CDD:289987	49/93 (53%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	127/208 (61%)
atp1a1a.4	NP_571764.1	ATPase-IIC_X-K	32..1024	CDD:273445	625/991 (63%)
		Cation_ATPase_N	41..115	CDD:214842	37/73 (51%)
		E1-E2_ATPase	135..366	CDD:278548	155/230 (67%)
		Cation_ATPase	428..522	CDD:289987	49/93 (53%)
		COG4087	607..753	CDD:226572	106/145 (73%)
		Cation_ATPase_C	800..1009	CDD:279079	127/208 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593929
Domainoid	1	1.000	124	1.000	Domainoid score	I5444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D50082at33208
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860