DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp1a1a.2

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_571762.1	Gene:	atp1a1a.2 / 64613	ZFINID:	ZDB-GENE-001212-2	Length:	1023	Species:	Danio rerio

Alignment Length:	1012	Identity:	618/1012 - (61%)
Similarity:	768/1012 - (75%)	Gaps:	3/1012 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPKKKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEING 65
            :.|..:::..|....::|||:...||:||.|:||:.:|||..:..|....|||...||..||.:|
Zfish    12 LTPTSEDELKKTKKGKRKKDVDELKKEVELDDHKLTLDELSRKYGTGMIKGLSSFRAKEILERDG 76

  Fly    66 PNILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVI 130
            ||.|||.|.||:|:.|.|.:||||..|||.|:||||:.|.||:.:..:...||||||:.|..:||
Zfish    77 PNALTPPPTTPQWVKFCKLLFGGFQTLLWFGAFLCFLAYGIQVASVEDAAHDNLYLGLVLAFVVI 141

  Fly   131 VTGLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRIL 195
            |.|.|:::|..|||.||:||:|||||.|.|:|:||...:.::|:|.||::||..|||:|||:||:
Zfish   142 VNGWFSFYQESKSSKIMESFRNLVPQQALVVRDGEKKVINAEEVVVGDLIEVCGGDRIPADLRIV 206

  Fly   196 EAHGLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIA 260
            .|.|.||||||||||||||.||.||:|||||||||:||||||.:|||.||:.|:|||.|:|||||
Zfish   207 YAQGCKVDNSSLTGESEPQSRSPEFSHENPLETKNIAFFSTNCVEGTARGIAISTGDRTIMGRIA 271

  Fly   261 NLAAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGL 325
            :||:.|:..|:||:|||:.||..|:..:|.||::||.:||.|||.:|:|||||||||||||||||
Zfish   272 SLASSLEGGQTPIAREIEHFIHIISAVSIFLGVTFFVLSLILGYAWIEAVVFLIGIIVANVPEGL 336

  Fly   326 LVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESD 390
            ..||||||||||||||.|||||||||||||||||:|||||||||||||||||||:|:|..|.|:|
Zfish   337 PATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQNRMTVAHMWFDSQIHEAD 401

  Fly   391 TTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAG 455
            |||:..|:.|.....::.||...|.|||.|.|:..|..:||..::..|:|||:||||..|.....
Zfish   402 TTENQSGTSFDRSSPTWAALARVAGLCNRAVFRAEQSHLPVLNRETAGDASESALLKCIELCCGS 466

  Fly   456 IGAFRQKHIKLTEIPFNSTEKYQVSVHEFNSSDG-YFIVEMKGAPERILDRCSTIIIQGLSVELT 519
            :...|:|:.|:.|||||||.|||:|||:..||.| ..::.|||||||||||||||:|.|....:.
Zfish   467 VIEMREKYRKICEIPFNSTNKYQLSVHKNPSSSGTKHLLVMKGAPERILDRCSTILINGKEQPMD 531

  Fly   520 PTLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPR 584
            ...|..|:.||:|:||:|||||||....||..::|..:.|..:..|||.|||.||||:|:|||||
Zfish   532 DENKDSFQSAYVELGGLGERVLGFCQYNLPDDQFPEGFAFDPEDVNFPTENLCFLGLMSMIDPPR 596

  Fly   585 AAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQAT 647
            ||||||||||||||::||||||||||||||||:.||||:  ..|.||||.:..:.|.:::.|:|.
Zfish   597 AAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARMNIPVGEVNPREAK 661

  Fly   648 AIVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALK 712
            |.|||||||:.|...:||.::.||.|||||||||||||||||.|||:|.||||||||||||||||
Zfish   662 ACVVHGGELKNMNDSDLDEILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALK 726

  Fly   713 RADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFL 777
            :||||||||||||||||||||||||||||||||.|:||||:|||||||||||||||.:||:.|||
Zfish   727 KADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFL 791

  Fly   778 FFVIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQ 842
            .||:..|||.|||:.||.||:|||::||||.|||.||:|||.|.||:..:|||||::||.|||.|
Zfish   792 MFVVVGIPLPLGTVTILFIDLGTDLIPAISYAYENAENDIMKRQPRNAQKDRLVNERLISMAYGQ 856

  Fly   843 IGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTG 907
            ||:||.||.|||:..:|||:||.||.|.|:|..|:.:::.||||.|||:|||..||::|.|..|.
Zfish   857 IGMIQAVAGFFTYITVMAENGFRPSYLPGLRVGWEDRSIGDLEDSYGQQWTYEGRKIIESTCHTA 921

  Fly   908 FFVSIVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFI 972
            ||:||||.|..||||.||||||||||||.|.||.||...|..:|..|.|.|..:..:|||.::.:
Zfish   922 FFISIVVVQWADLLIVKTRRNSILQQGMKNKVLIFAFFEEGALAAFLSYCPGMDIAVRMYPLRPL 986

  Fly   973 WWIYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            ||..|.|:.|:|||:||.|::::||||||:||:||||
Zfish   987 WWFTALPYALIIFFYDEIRKYILRRNPGGFVEKETYY 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	614/994 (62%)
		Cation_ATPase_N	29..102	CDD:214842	38/72 (53%)
		E1-E2_ATPase	123..354	CDD:278548	152/230 (66%)
		Cation_ATPase	416..509	CDD:289987	49/93 (53%)
		COG4087	<673..738	CDD:226572	60/64 (94%)
		Cation_ATPase_C	785..994	CDD:279079	120/208 (58%)
atp1a1a.2	NP_571762.1	ATPase-IIC_X-K	31..1023	CDD:273445	612/991 (62%)
		Cation_ATPase_N	40..114	CDD:214842	39/73 (53%)
		E1-E2_ATPase	134..365	CDD:278548	152/230 (66%)
		Cation_ATPase	427..521	CDD:289987	49/93 (53%)
		COG4087	<677..752	CDD:226572	64/74 (86%)
		Cation_ATPase_C	799..1008	CDD:279079	120/208 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593926
Domainoid	1	1.000	87	1.000	Domainoid score	I7947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860