DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp1a3b

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_571760.2	Gene:	atp1a3b / 64611	ZFINID:	ZDB-GENE-001212-8	Length:	1023	Species:	Danio rerio

Alignment Length:	1009	Identity:	627/1009 - (62%)
Similarity:	779/1009 - (77%)	Gaps:	5/1009 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KNKEHKINGKEKK--KDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNI 68
            ::|:.|.:.|:||  ||:...||:|....||:.|:|:..:.:||...||:..:|:..|..:|||.
Zfish    15 QDKDEKGSPKKKKGAKDLDDLKKEVPLTEHKMSVEEVCRKFQTDIVQGLTNAKARDFLARDGPNA 79

  Fly    69 LTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTG 133
            |||.|.||:|:.|.:.:||||:||||.|:.|||:.|.||..|:.:|..|||||||.|:.:||:||
Zfish    80 LTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYAIQAATEDDPAGDNLYLGIVLSAVVIITG 144

  Fly   134 LFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAH 198
            .|:|||..|||.||:||||:|||.|.||||||...:.::|:|.||:||||.|||:|||:||:.||
Zfish   145 CFSYFQEAKSSKIMESFKNMVPQQALVIREGEKMQINAEEVVAGDLVEVKGGDRIPADLRIISAH 209

  Fly   199 GLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLA 263
            |.||||||||||||||.||.:.||:|||||:|:||||||.:|||.||||:.|||.|||||||.|.
Zfish   210 GCKVDNSSLTGESEPQTRSPDCTHDNPLETRNIAFFSTNCVEGTARGVVVCTGDRTVMGRIATLT 274

  Fly   264 AGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVT 328
            :||:..::||::||:.||..||..|:.||:|||.:::.|||.:::||:|||||||||||||||.|
Zfish   275 SGLETGKTPIAKEIEHFIHIITGVAVFLGVSFFILAVILGYTWLEAVIFLIGIIVANVPEGLLAT 339

  Fly   329 VTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTE 393
            |||||||||||||.|||||||||||||||||||||||||||||||||||||.|:|..|.|:||||
Zfish   340 VTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHKWFDNQIHEADTTE 404

  Fly   394 SFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGA 458
            ...|:.|.....::.||...|||||.|.||.|||.:|:.|:||.|:|||:||||..|.....:.|
Zfish   405 DQSGASFDKSSVTWVALARVAALCNRAVFKAGQDSLPILKRDVAGDASESALLKCIELSSGSVKA 469

  Fly   459 FRQKHIKLTEIPFNSTEKYQVSVHEF-NSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTL 522
            .|:|:.|:.|||||||.|||:|:||. :::|..:::.|||||||||||||||::||....:...:
Zfish   470 MREKNKKVAEIPFNSTNKYQLSIHETEDNNDNRYLLVMKGAPERILDRCSTIMLQGKEQPMDEEM 534

  Fly   523 KLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAV 587
            |..|:.||||:||:|||||||..:|:|..:||..:.|..|..||..:||.|:||:|:||||||||
Zfish   535 KEAFQNAYLELGGLGERVLGFCHVLMPEDQYPKGFAFDTDDVNFQTDNLCFVGLMSMIDPPRAAV 599

  Fly   588 PDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIV 650
            ||||.||||||::||||||||||||||||:.||||:  ..|.||||.:..:.|..::.|.|.|.|
Zfish   600 PDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACV 664

  Fly   651 VHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRAD 715
            :||.:|::...|::|.|:..|.|||||||||||||||||.|||:|.||||||||||||||||:||
Zfish   665 IHGTDLKDYSQEQIDEVLRNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 729

  Fly   716 IGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFV 780
            ||||||||||||||||||.|||||||||||.|:||||:||||||||||||||||:|||.|||.|:
Zfish   730 IGVAMGISGSDVSKQAADTILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFI 794

  Fly   781 IFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGV 845
            |.:|||.||||.|||||:||||:||||||||.||||||.|.||:|..|:|||::||.:||.|||:
Zfish   795 IVNIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPMRDKLVNERLISIAYGQIGM 859

  Fly   846 IQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFV 910
            ||.:..||.:|.|:||:||.||.|.|||.:||.:.:.||||.|||:|||.:||::|:|..|.|||
Zfish   860 IQALGGFFAYFVILAENGFLPSLLVGIRLNWDDRAMNDLEDSYGQQWTYEQRKIVEFTCHTAFFV 924

  Fly   911 SIVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWI 975
            ||||.|..|::||||||||:.||||.|.:|.|.|..|..:|..|.|.|..:..||||.:|..||.
Zfish   925 SIVVVQWADVIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWF 989

  Fly   976 YAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            .|||:..|||.:||.|:.|:|||||||||:||||
Zfish   990 CAFPYSFLIFVYDEVRKLLLRRNPGGWVEKETYY 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	622/996 (62%)
		Cation_ATPase_N	29..102	CDD:214842	32/72 (44%)
		E1-E2_ATPase	123..354	CDD:278548	156/230 (68%)
		Cation_ATPase	416..509	CDD:289987	53/93 (57%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	123/208 (59%)
atp1a3b	NP_571760.2	ATPase-IIC_X-K	25..1023	CDD:273445	622/997 (62%)
		Cation_ATPase_N	41..114	CDD:214842	33/72 (46%)
		E1-E2_ATPase	134..365	CDD:278548	156/230 (68%)
		Cation_ATPase	427..521	CDD:289987	53/93 (57%)
		COG4087	606..>732	CDD:226572	82/125 (66%)
		Cation_ATPase_C	799..1008	CDD:279079	123/208 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5444
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930