DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and ATP2A2

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_733765.1	Gene:	ATP2A2 / 488	HGNCID:	812	Length:	1042	Species:	Homo sapiens

Alignment Length:	1050	Identity:	313/1050 - (29%)
Similarity:	496/1050 - (47%)	Gaps:	142/1050 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQPPTPKWIVFLKTMFGGF-----AIL 92
            |...|:|:|.....:.:.|||..:.|...|..|.|.|    |..:....|:.:...|     .||
Human     5 HTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNEL----PAEEGKTLLELVIEQFEDLLVRIL 65

  Fly    93 LWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQVHKSSSIMDSFKNLVPQY 157
            |.|.   | :.:::....:.|...........:.::::...:...:|...:.:.:::.|...|:.
Human    66 LLAA---C-ISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEM 126

  Fly   158 ATVIREG--EINTVTSDEIVKGDIVEVKFGDRVPADIRI--LEAHGLKVDNSSLTGESEPQVRST 218
            ..|.|:.  .:..:.:.:||.|||||:..||:||||||:  :::..|:||.|.|||||...::
Human   127 GKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIK-- 189

  Fly   219 EFTHENPL--------ETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDDVQSPISR 275
               |.:|:        :.||:.|..||:..|...|||:|||.:|.:|:|.:.....:..::|:.:
Human   190 ---HTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQ 251

  Fly   276 EIQLF-------IRFITIFAIILGLSFFAISLTLGYEFIDAVVFL---IGIIVANVPEGLLVTVT 330
            ::..|       |..|.|...|:.:..|...:..|.....|:.:.   :.:.||.:||||...:|
Human   252 KLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVIT 316

  Fly   331 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLW-YDQIIVESDTTE- 393
            .||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..:: .|:  ||.||..
Human   317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDR--VEGDTCSL 379

  Fly   394 ---SFRGSHF------KIEDKSFNA--------LFMCAALCNSA-----EFKGGQDDIPVFKKDV 436
               :..||.:      ..:||..|.        |....||||.:     |.||      |::|
Human   380 NEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG------VYEK-- 436

  Fly   437 NGNASEAAL------LKFTETIFAGIGAFRQ--------KHIKLTEIPFN-STEKYQVSVH---- 482
            .|.|:|.||      :...:|...|:....:        |.:...|.... |.::..:||:
Human   437 VGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPN 501

  Fly   483 --EFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMGGMGE--RVLGF 543
              ...|....|:   |||||.::|||:.|.:....|.:|..:|.:......|.|...:  |.|..
Human   502 KPSRTSMSKMFV---KGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLAL 563

  Fly   544 ADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAKCRSAGVRVIMVTGDH 608
            |....|:.:..:..|.||:...:. .||.|:|.:.::||||..|..:|..||.||:||||:|||:
Human   564 ATHDNPLRREEMHLEDSANFIKYE-TNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDN 627

  Fly   609 PITAKAIARSVGIITTPTAEDIAKQRGVTVLDIDSRQATAIVVHGGELREMK-AEELDAVIYYHN 672
            ..||.||.|.:||.    .:|         .|:.|:..|     |.|..|:. :.:.||.:   |
Human   628 KGTAVAICRRIGIF----GQD---------EDVTSKAFT-----GREFDELNPSAQRDACL---N 671

  Fly   673 EIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDVSKQAADMILL 737
            ...|||..|..|..|||..|...||.|:|||||||:||||:|:||:||| ||:.|:|.|::|:|.
Human   672 ARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLA 735

  Fly   738 DDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLALGTIAILCIDIGTDM 802
            ||||::||..:||||.|::|:|:.|.|.::||:.|:|..........|.||..:.:|.:::.||.
Human   736 DDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDG 800

  Fly   803 LPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGV---IQTVACFFTFFAIMAEHGF 864
            |||.:|.:...:.|||.:.||:|.|..:  ...:...||.||.   ..||.....:|  :|..|.
Human   801 LPATALGFNPPDLDIMNKPPRNPKEPLI--SGWLFFRYLAIGCYVGAATVGAAAWWF--IAADGG 861

  Fly   865 PPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVT-QVFDLLICKTRRN 928
            |......:......|  ||..|..|.:..     :.|........:|::|| ::.:.|...:...
Human   862 PRVSFYQLSHFLQCK--EDNPDFEGVDCA-----IFESPYPMTMALSVLVTIEMCNALNSLSENQ 919

  Fly   929 SILQQGMGNHV-LNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYAFPFGLLIFFFDESRR 992
            |:|:.....:: |..::.|...:..|:.||.......::..:....|:......|.:...||:.:
Human   920 SLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLK 984

  Fly   993 FLIRR--NPG 1000
            |:.|.  .||
Human   985 FVARNYLEPG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	312/1049 (30%)
		Cation_ATPase_N	29..102	CDD:214842	20/73 (27%)
		E1-E2_ATPase	123..354	CDD:278548	72/252 (29%)
		Cation_ATPase	416..509	CDD:289987	30/118 (25%)
		COG4087	<673..738	CDD:226572	36/64 (56%)
		Cation_ATPase_C	785..994	CDD:279079	48/213 (23%)
ATP2A2	NP_733765.1	Cation_ATPase_N	4..72	CDD:279080	20/74 (27%)
		ATPase-IIA1_Ca	53..988	CDD:273452	296/990 (30%)
		E1-E2_ATPase	93..340	CDD:278548	72/251 (29%)
		Cation_ATPase	419..527	CDD:289987	30/118 (25%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:18971376	575..594		6/19 (32%)
		HAD	<605..711	CDD:289480	51/126 (40%)
		Cation_ATPase_C	783..986	CDD:279079	48/213 (23%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		6/19 (32%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250\|UniProtKB:O55143	788..1042		48/217 (22%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920