DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and ATP12A

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_001172014.1	Gene:	ATP12A / 479	HGNCID:	13816	Length:	1045	Species:	Homo sapiens

Alignment Length:	1025	Identity:	553/1025 - (53%)
Similarity:	728/1025 - (71%)	Gaps:	23/1025 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KEHKINGKE-------------KKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKL 59
            |..|.:|||             ||...:.|:|::..|:||:...||.|:..||..||||...|..
Human    21 KTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAE 85

  Fly    60 RLEINGPNILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIA 124
            .|..:|||.|||...||:.:.|||.|.|||:||||.|:|||::.|.||..:......:|:|||..
Human    86 LLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCV 150

  Fly   125 LTVLVIVTGLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVP 189
            |.::||:||:|.|:|..||::||.||..::||.|.|||:.|..|:.|:::|.|||||||.||::|
Human   151 LGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIP 215

  Fly   190 ADIRILEAHGLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLE------GTCRGVVI 248
            ||||:|.:.|.:|||||||||||||.||:||||||||||||:.|:||..||      ||..|:||
Human   216 ADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEASTSPVGTVTGMVI 280

  Fly   249 ATGDSTVMGRIANLAAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFL 313
            .|||.|::|.||:||:|:.:.::||:.||:.|:..:...|:.:|:.||.|:::|.|:.:|:::||
Human   281 NTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFL 345

  Fly   314 IGIIVANVPEGLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVA 378
            |||||||||||||.||||.|:|||||||.||||||||||||||||||.|||||||||||||||||
Human   346 IGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVA 410

  Fly   379 HLWYDQIIVESDTTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEA 443
            |||:|..|..:||:|......|....:::.:|.....|||.||||.||:::|:.||.|.|:|||.
Human   411 HLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASET 475

  Fly   444 ALLKFTETIFAGIGAFRQKHIKLTEIPFNSTEKYQVSVHEFNSSDG-YFIVEMKGAPERILDRCS 507
            |||||:|.|...:...|:::.|:.|||||||.|:|:|:||.:...| .|::.|||||||||::||
Human   476 ALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCS 540

  Fly   508 TIIIQGLSVELTPTLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLR 572
            ||:|.|....|..:....|..||:|:||:|||||||..|.||..::|.:|.|..|..|||..||.
Human   541 TIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLC 605

  Fly   573 FLGLISLIDPPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRG 635
            |:||:|:|||||:.|||||.||||||::||||||||||||||||:|||||:  :.|.||||.:..
Human   606 FVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLN 670

  Fly   636 VTVLDIDSRQATAIVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAV 700
            :.|..::.|.|.|.||.|.||::|.:|:||.::..:.|||||||||||||||||.|||:..:|||
Human   671 IAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAV 735

  Fly   701 TGDGVNDSPALKRADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYT 765
            ||||||||||||:||||:||||:|||.:|.||||:||||||||||.|:||||:|||||||:|||:
Human   736 TGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYS 800

  Fly   766 LTSNLPEIVPFLFFVIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRL 830
            ||.|:.|:.|||.::|..:||.:|||.||.||:|||::|:|:|||||||||||.|.||...:|||
Human   801 LTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRL 865

  Fly   831 VNKKLILMAYLQIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYR 895
            ||:.|.:.:||.||::|.:..|..:|.:.|:.||.|..|..:|.:|:...|.||:|.||||||..
Human   866 VNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRY 930

  Fly   896 ERKVLEYTAGTGFFVSIVVTQVFDLLICKTRRNSILQQGM-GNHVLNFALVLEFIIACLLCYVPV 959
            :|:.||:|..|.|||.|:|.|:.||:|.|||||||.|||: .|.|:...:..:.||..:|.|...
Human   931 QREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLG 995

  Fly   960 FEKTLRMYSIKFIWWIYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            ....|....::..:|..|.|..:||:.:||.|:..||..||.|.::..||
Human   996 SVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	546/1001 (55%)
		Cation_ATPase_N	29..102	CDD:214842	37/72 (51%)
		E1-E2_ATPase	123..354	CDD:278548	137/236 (58%)
		Cation_ATPase	416..509	CDD:289987	51/93 (55%)
		COG4087	<673..738	CDD:226572	52/64 (81%)
		Cation_ATPase_C	785..994	CDD:279079	97/209 (46%)
ATP12A	NP_001172014.1	ATPase-IIC_X-K	42..1045	CDD:273445	546/1002 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6717
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930